Although the brain can discriminate between various sweet substances, the underlying neural mechanisms of this complex behavior remain elusive. This study examines the role of the anterior paraventricular nucleus of the thalamus (aPVT) in governing sweet preference in mice. We fed the mice six different diets with equal sweetness for six weeks: control diet (CD),… Continue reading Neuronal activity in the anterior paraventricular nucleus of thalamus positively correlated with #sweetener consumption in mice
#ELECTRONIC NICOTINE PRODUCT USE IS ASSOCIATED WITH INCIDENT #HEART FAILURE – THE ALL OF US RESEARCH PROGRAM
An #osteoarthritis pathophysiological continuum revealed by molecular #biomarkers
We aimed to identify serum biomarkers that predict knee osteoarthritis (OA) before the appearance of radiographic abnormalities in a cohort of 200 women. As few as six serum peptides, corresponding to six proteins, reached AUC 77% probability to distinguish those who developed OA from age-matched individuals who did not develop OA up to 8 years… Continue reading An #osteoarthritis pathophysiological continuum revealed by molecular #biomarkers
Food #additive emulsifiers and the risk of type 2 #diabetes: analysis of data from the NutriNet-Santé prospective cohort study
Experimental studies have suggested potential detrimental effects of emulsifiers on gut microbiota, inflammation, and metabolic perturbations. We aimed to investigate the associations between exposures to food additive emulsifiers and the risk of type 2 diabetes in a large prospective cohort of French adults.MethodsWe analysed data from 104 139 adults enrolled in the French NutriNet-Santé prospective cohort… Continue reading Food #additive emulsifiers and the risk of type 2 #diabetes: analysis of data from the NutriNet-Santé prospective cohort study
Long-term exposure to residential #greenness and decreased risk of #depression and #anxiety
Residential greenness is considered a unique and potentially modifiable exposure construct to reduce physiological stress and improve human health. Here this study aims to investigate the longitudinal relationships of residential greenness with incident depression and anxiety and to explore and compare the pathways in which greenery may influence mental health. After excluding participants with depression… Continue reading Long-term exposure to residential #greenness and decreased risk of #depression and #anxiety
Navigating the #Vasculature: A Physician’s Guide to Cerebral #Angiography
n the ever-evolving landscape of medical diagnostics, cerebral angiography stands out as a powerful tool that allows physicians to delve into the intricate network of blood vessels within the brain. As physicians, our commitment to accurate diagnosis and comprehensive patient care often leads us to explore advanced imaging techniques. In this blog post, we will… Continue reading Navigating the #Vasculature: A Physician’s Guide to Cerebral #Angiography
Use of #Acid-Suppression Therapy and Odds of #Migraine and Severe Headache in the National Health and Nutrition Examination Survey
Headache is an adverse event associated with the use of proton pump inhibitors (PPIs). Recently, migraine has emerged more specifically as a potential adverse event with PPI use. The objectives of this work were to capitalize on existing data to evaluate the association between migraine and severe headache prevalence and use of acid-suppression therapy, including… Continue reading Use of #Acid-Suppression Therapy and Odds of #Migraine and Severe Headache in the National Health and Nutrition Examination Survey
Effect of long-term #caloric restriction on telomere length in healthy adults: CALERIE™ 2 trial analysis
Caloric restriction (CR) modifies lifespan and aging biology in animal models. The Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE™) 2 trial tested translation of these findings to humans. CALERIE™ randomized healthy, nonobese men and premenopausal women (age 21–50y; BMI 22.0–27.9 kg/m2), to 25% CR or ad-libitum (AL) control (2:1) for 2 years. Prior… Continue reading Effect of long-term #caloric restriction on telomere length in healthy adults: CALERIE™ 2 trial analysis
Continuous #glucose monitoring and intrapersonal variability in fasting #glucose
Plasma fasting glucose (FG) levels play a pivotal role in the diagnosis of prediabetes and diabetes worldwide. Here we investigated FG values using continuous glucose monitoring (CGM) devices in nondiabetic adults aged 40–70 years. FG was measured during 59,565 morning windows of 8,315 individuals (7.16 ± 3.17 days per participant). Mean FG was 96.2 ± 12.87 mg dl−1, rising by 0.234 mg dl−1 per year with… Continue reading Continuous #glucose monitoring and intrapersonal variability in fasting #glucose
2 Medical News 