Highlights•Environmental pollution could affect diversity of resident microbiota. •Environmental pollution could affect abundance of resident microbiota. •Studies suggest air pollution increases the abundance of streptococcus. •Studies suggest air pollution increases the abundance of veillionellales. •Scarcity of studies precludes observing consistent trends for other microbiota. AbstractA rich body of literature indicates that environmental factors interact with… Continue reading Air pollution and endocrine disruptors induce human microbiome imbalances: A systematic review of recent evidence and possible biological mechanisms
The role of different lipid measures for incident hypertension during more than 12 years follow-up: Tehran Lipid and Glucose Study
To examine the associations of different lipid measures and related indices with incident hypertension during a median follow-up of 12.89 years. Fasting levels of total cholesterol (TC), triglycerides (TG), high and low density lipoprotein cholesterol (HDL-C and LDL-C, respectively), and related indices (TC/HDL-C and TG/HDL-C) were determined in 7335 Iranian adults (men=3270) free of hypertension,… Continue reading The role of different lipid measures for incident hypertension during more than 12 years follow-up: Tehran Lipid and Glucose Study
The epidemiological relevance of the COVID-19-vaccinated population is increasing
High COVID-19 vaccination rates were expected to reduce transmission of SARS-CoV-2 in populations by reducing the number of possible sources for transmission and thereby to reduce the burden of COVID-19 disease. Recent data, however, indicate that the epidemiological relevance of COVID-19 vaccinated individuals is increasing. In the UK it was described that secondary attack rates… Continue reading The epidemiological relevance of the COVID-19-vaccinated population is increasing
Elapsed time since BNT162b2 vaccine and risk of SARS-CoV-2 infection: test negative design study
To determine whether time elapsed since the second injection of the Pfizer-BioNTech BNT162b2 mRNA vaccine was significantly associated with the risk of covid-19 infection after vaccination in people who received two vaccine injections. Design Test negative design study. Setting Electronic health records of a large state mandated healthcare organisation, Israel. Participants Adults aged ≥18 years… Continue reading Elapsed time since BNT162b2 vaccine and risk of SARS-CoV-2 infection: test negative design study
The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids
The endocannabinoid (EC) system has pleiotropic functions in the body. It plays a key role in energy homeostasis and the development of metabolic disorders being a mediator in the relationship between the gut microbiota and host metabolism. In the current study we explore the functional interactions between the endocannabinoid system and the gut microbiome in… Continue reading The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids
Abstract 10712: Mrna COVID Vaccines Dramatically Increase Endothelial Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac Test: a Warning
Our group has been using the PLUS Cardiac Test (GD Biosciences, Inc, Irvine, CA) a clinically validated measurement of multiple protein biomarkers which generates a score predicting the 5 yr risk (percentage chance) of a new Acute Coronary Syndrome (ACS). The score is based on changes from the norm of multiple protein biomarkers including IL-16,… Continue reading Abstract 10712: Mrna COVID Vaccines Dramatically Increase Endothelial Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac Test: a Warning
Lithium Treatment in the Prevention of Repeat Suicide-Related Outcomes in Veterans With Major Depression or Bipolar DisorderA Randomized Clinical Trial
Suicide and suicide attempts are persistent and increasing public health problems. Observational studies and meta-analyses of randomized clinical trials have suggested that lithium may prevent suicide in patients with bipolar disorder or depression. Objective To assess whether lithium augmentation of usual care reduces the rate of repeated episodes of suicide-related events (repeated suicide attempts, interrupted… Continue reading Lithium Treatment in the Prevention of Repeat Suicide-Related Outcomes in Veterans With Major Depression or Bipolar DisorderA Randomized Clinical Trial
The 3p21.31 genetic locus promotes progression to type 1 diabetes through the CCR2/CCL2 pathway
•Serum CCL-2 levels are lower in individuals with islet autoantibodies and type 1 diabetes compared to controls. •The 3p21.31 genetic locus is associated with type 1 diabetes. •Serum CCL-2 levels are associated with the 3p21.31 genetic locus. •The 3p21.31 genetic locus is associated with gene expression of the CCL-2 receptor, CCR2. AbstractMultiple cross-sectional and longitudinal… Continue reading The 3p21.31 genetic locus promotes progression to type 1 diabetes through the CCR2/CCL2 pathway
Thyroid as a target of adjuvant autoimmunity/inflammatory syndrome due to mRNA-based SARS-CoV2 vaccination: from Graves’ disease to silent thyroiditis
BackgroundAs COVID-19 became a pandemic, the urgent need to find an effective treatment vaccine has been a major objective. Vaccines contain adjuvants which are not exempt from adverse effects and can trigger the autoimmune/inflammatory syndrome induced by adjuvants (ASIA). There is very little information about autoimmune endocrine disease and the ASIA after the use of… Continue reading Thyroid as a target of adjuvant autoimmunity/inflammatory syndrome due to mRNA-based SARS-CoV2 vaccination: from Graves’ disease to silent thyroiditis
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