BackgroundTo my knowledge, this is the first case series of costochondritis treated by acupuncture. Eight cases are presented, the majority being seen in primary care.Costochondritis is a debilitating condition characterised by severe anterior or lateral chest pain, associated with tenderness of the second to fifth costochondral (CC) joints. Tietze’s syndrome is a rare variant with… Continue reading #Acupuncture appears to be a rapidly effective treatment for #costochondritis
Very High Prevalence of Nonoptimally Controlled Traditional #Risk Factors at the Onset of #Cardiovascular Disease
BackgroundRecent studies suggest that coronary heart disease (CHD) may frequently occur in the absence of traditional cardiovascular disease (CVD) risk factors. However, it is unclear whether this could reflect missed clinical diagnoses or subthreshold nonoptimal risk factor exposure preceding CHD, and whether similar patterns are observed for heart failure (HF) or stroke.ObjectivesThe purpose of this… Continue reading Very High Prevalence of Nonoptimally Controlled Traditional #Risk Factors at the Onset of #Cardiovascular Disease
Monoclonal #antibodies protect against pandrug-resistant #Klebsiella pneumoniae
The ‘silent pandemic’ caused by antimicrobial resistance requires innovative therapeutic approaches. Human monoclonal antibodies (mAbs), which are among the most transformative and safe drugs in oncology1 and autoimmunity2, are rarely used for infectious diseases and not yet used for antimicrobial resistance3. Here we applied an antigen-agnostic strategy to isolate extremely potent human mAbs against Klebsiella… Continue reading Monoclonal #antibodies protect against pandrug-resistant #Klebsiella pneumoniae
The state of #evidence in acupuncture: A #review of #metaanalyses and systematic reviews of acupuncture evidence (update 2017–2022)
Highlights•Compared to previous years, the amount and quality of acupuncture evidence has severely increased in the years 2017–2022.•Acupuncture showed evidence of positive effect for ten medical conditions and thus should be applied in clinical settings.•In most of the remaining 174 medical indications acupuncture showed some beneficial effects, no effect in six of them.•Overall, acupuncture is… Continue reading The state of #evidence in acupuncture: A #review of #metaanalyses and systematic reviews of acupuncture evidence (update 2017–2022)
Effect of Varying Quantities of Lean #Beef as Part of a #Mediterranean‐Style #Dietary Pattern on Gut #Microbiota and Plasma, Fecal, and Urinary Metabolites: A Randomized Crossover Controlled Feeding Trial
Consumption of trimethylamine N‐oxide (TMAO) precursors, such as carnitine found in lean beef, raises circulating TMAO concentrations; however, a healthy dietary pattern may attenuate these effects.MethodsThis randomized, 4‐period crossover, controlled‐feeding study investigated the effects of Mediterranean‐style (MED) diets (carbohydrate 42%, protein 17%, fat 41%) with 14 (MED0.5; 0.5 oz), 71 (MED2.5; 2.5 oz), and 156… Continue reading Effect of Varying Quantities of Lean #Beef as Part of a #Mediterranean‐Style #Dietary Pattern on Gut #Microbiota and Plasma, Fecal, and Urinary Metabolites: A Randomized Crossover Controlled Feeding Trial
#Coffee for the #liver: a mechanistic approach
The liver, which is essential for metabolism and detoxification, is vulnerable to various damaging factors, including viral infections, excessive alcohol consumption, and a diet high in fat and sugar. Coffee, one of the most widely consumed beverages worldwide, is valued not only for its flavor and aroma but also for its potential health benefits. In… Continue reading #Coffee for the #liver: a mechanistic approach
Progression to #rheumatoid arthritis in at-risk individuals is defined by systemic #inflammation and by T and B cell dysregulation
Rheumatoid arthritis (RA) is preceded by an at-risk stage of disease that can be marked by the presence of anticitrullinated protein antibodies (ACPAs) but the absence of clinically apparent synovitis (clinical RA). Preemptive intervention in at-risk individuals could prevent or delay future tissue damage; however, the immunobiology of this stage is unclear. Using integrative multiomics,… Continue reading Progression to #rheumatoid arthritis in at-risk individuals is defined by systemic #inflammation and by T and B cell dysregulation
Effect of #Metformin on the Risk of Post- #coronavirus Disease 2019 Condition Among Individuals With #Overweight or #Obese: A Population-based Retrospective Cohort Study
BackgroundA subgroup analysis of the COVID-OUT trial's long-term outcome found that starting metformin within 3 days of coronavirus disease 2019 (COVID-19) diagnosis reduced post–COVID-19 condition (PCC) incidence by 63% in overweight or obese individuals. However, its generalizability remains uncertain.ObjectivesTo evaluate the effectiveness of metformin in preventing PCC in adults with overweight or obesity who had… Continue reading Effect of #Metformin on the Risk of Post- #coronavirus Disease 2019 Condition Among Individuals With #Overweight or #Obese: A Population-based Retrospective Cohort Study
Unlocking deep #relaxation: the power of #rhythmic #breathing on brain rhythms
The pandemic has exacerbated mental health issues across the world. The limited availability of mental health professionals is preventing many from seeking help, which highlights the need for easily available mental health care routines like yoga, breathing, and meditation. A breath-based meditation technique known as Sudarshan Kriya #Yoga (SKY) harnesses the power of breath to… Continue reading Unlocking deep #relaxation: the power of #rhythmic #breathing on brain rhythms
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