Since today and until August 31th, there will be just One daily update to the blogsite. Frohe Feiertage Euch Allen!
Vaccine mRNA Can Be Detected in Blood at 15 Days Post-Vaccination
COVID-19 mRNA vaccines effectively reduce incidence of severe disease, hospitalisation and death. The biodistribution and pharmacokinetics of the mRNA-containing lipid nanoparticles (LNPs) in these vaccines are unknown in humans. In this study, we used qPCR to track circulating mRNA in blood at different time-points after BNT162b2 vaccination in a small cohort of healthy individuals. We… Continue reading Vaccine mRNA Can Be Detected in Blood at 15 Days Post-Vaccination
Effects of wearing FFP2 masks on SARS-CoV-2 infection rates in classrooms
Importance: Different mitigation measures are mandated in schools worldwide to control the spread of SARS-CoV-2. The efficacy of most measures, however, has not been investigated thus far. Objective: To investigate the usefulness of FFP-2 masks in classrooms to prevent the spread of SARS-CoV-2. Design: A retrospective comparative cohort study of infection rates (evaluated by PCR… Continue reading Effects of wearing FFP2 masks on SARS-CoV-2 infection rates in classrooms
Sex-specific associations between potassium intake, blood pressure, and cardiovascular outcomes: the EPIC-Norfolk study
AimsA potassium replete diet is associated with lower blood pressure (BP) and lower risk of cardiovascular disease (CVD). Whether these associations differ between men and women and whether they depend on daily sodium intake is unknown.Methods and resultsAn analysis was performed in 11 267 men and 13 696 women from the EPIC-Norfolk cohort. Twenty-four hour excretion of… Continue reading Sex-specific associations between potassium intake, blood pressure, and cardiovascular outcomes: the EPIC-Norfolk study
Psilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controls
Psilocybin microdosing involves repeated self-administration of mushrooms containing psilocybin at doses small enough to not impact regular functioning. Microdose practices are diverse and include combining psilocybin with substances such as lion’s mane mushrooms (Hericium erinaceus; HE) and niacin (vitamin-B3). Public uptake of microdosing has outpaced evidence, mandating further prospective research. Using a naturalistic, observational design,… Continue reading Psilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controls
Association of Nap Frequency With Hypertension or Ischemic Stroke Supported by Prospective Cohort Data and Mendelian Randomization in Predominantly Middle-Aged European Subjects
Background and Purpose:The aim of this study was to investigate the association between daytime napping frequency and the incidence of essential hypertension or stroke as well as to validate causality in this relationship via Mendelian randomization (MR).Methods:We conducted Cox regression analysis on 358 451 participants free of hypertension or stroke from UK Biobank. To validate the… Continue reading Association of Nap Frequency With Hypertension or Ischemic Stroke Supported by Prospective Cohort Data and Mendelian Randomization in Predominantly Middle-Aged European Subjects
Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022
Before April 2022, monkeypox virus infection in humans was seldom reported outside African regions where it is endemic. Currently, cases are occurring worldwide. Transmission, risk factors, clinical presentation, and outcomes of infection are poorly defined.METHODSWe formed an international collaborative group of clinicians who contributed to an international case series to describe the presentation, clinical course,… Continue reading Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022
Laparoscopically Confirmed Endometriosis and Risk of Incident Stroke: A Prospective Cohort Study
AbstractBackground:Prior research suggests that women with endometriosis are at greater risk of coronary heart disease. Therefore, our objective was to prospectively investigate the association between laparoscopically confirmed endometriosis and risk of incident stroke during 28 years of follow-up.Methods:Participants in the NHSII cohort study (Nurses’ Health Study II) were followed from 1989 when they were between… Continue reading Laparoscopically Confirmed Endometriosis and Risk of Incident Stroke: A Prospective Cohort Study
Transient and durable T cell reactivity after COVID-19
This study analyzed whole blood samples (n = 56) retrieved from 30 patients at 1 to 21 (median 9) mo after verified COVID-19 to determine the polarity and duration of antigen-specific T cell reactivity against severe acute respiratory syndrome coronavirus 2–derived antigens. Multimeric peptides spanning the entire nucleocapsid protein triggered strikingly synchronous formation of interleukin… Continue reading Transient and durable T cell reactivity after COVID-19
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