Introduction: In 2020, prior to COVID-19 vaccine rollout, the Coalition for Epidemic Preparedness Innovations and Brighton Collaboration created a priority list, endorsed by the World Health Organization, of potential adverse events relevant to COVID-19 vaccines. We leveraged the Brighton Collaboration list to evaluate serious adverse events of special interest observed in phase III randomized trials… Continue reading Serious Adverse Events of Special Interest Following mRNA Vaccination in Randomized Trials
Does aspirin have an effect on risk of death in patients with COVID-19? A meta-analysis
The coronavirus disease 2019 (COVID-19) pandemic has shown unprecedented impact world-wide since the eruption in late 2019. Importantly, emerging reports suggest an increased risk of thromboembolism development in patients with COVID-19. Meanwhile, it is found that aspirin reduced mortality in critically ill patients with non-COVID-19 acute respiratory distress syndrome. Therefore, a meta-analysis was performed to… Continue reading Does aspirin have an effect on risk of death in patients with COVID-19? A meta-analysis
Ultrasonography in the prediction of gout flares: a 12-month prospective observational study
ObjectivesTo evaluate whether US findings indicating MSU deposits and US-detected inflammation (i.e. power Doppler signal) predict gout flares over 12 months.MethodsGout patients on urate-lowering therapy for at least the preceding 6 months were enrolled consecutively in this 12-month prospective, observational, single-centre study. A nested case–control analysis was performed. Cases were participants with at least one flare in… Continue reading Ultrasonography in the prediction of gout flares: a 12-month prospective observational study
Effects of salt substitutes on clinical outcomes: a systematic review and meta-analysis
Objectives The Salt Substitute and Stroke Study (SSaSS) recently reported blood pressure-mediated benefits of a potassium-enriched salt substitute on cardiovascular outcomes and death. This study assessed the effects of salt substitutes on a breadth of outcomes to quantify the consistency of the findings and understand the likely generalisability of the SSaSS results.Methods We searched PubMed,… Continue reading Effects of salt substitutes on clinical outcomes: a systematic review and meta-analysis
Rapidly Increasing Serum 25(OH)D Boosts the Immune System, against Infections—Sepsis and COVID-19
Vitamin D deficiency is a global public health problem, a pandemic that commonly affects the elderly and those with comorbidities such as obesity, diabetes, hypertension, respiratory disorders, recurrent infections, immune deficiency, and malignancies, as well as ethnic minorities living in temperate countries. The same groups were worst affected by COVID-19. Since vitamin D deficiency weakens… Continue reading Rapidly Increasing Serum 25(OH)D Boosts the Immune System, against Infections—Sepsis and COVID-19
Monkeypox outbreak predominantly affecting men who have sex with men, Madrid, Spain, 26 April to 16 June 2022
Monkeypox virus (MPXV) is an enveloped double-stranded DNA virus that belongs to the Orthopoxvirus genus of the Poxviridae family. There are two distinct genetic clades of the MPXV: the Central African (Congo Basin) clade and the West African clade. Monkeypox (MPX) is a viral zoonosis (a virus transmitted to humans from animals) with symptoms similar… Continue reading Monkeypox outbreak predominantly affecting men who have sex with men, Madrid, Spain, 26 April to 16 June 2022
Cardiovascular Effects of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents
This study focuses on cardiovascular effects, particularly myocarditis and pericarditis events, after BNT162b2 mRNA COVID-19 vaccine injection in Thai adolescents. This prospective cohort study enrolled students from two schools aged 13–18 years who received the second dose of the BNT162b2 mRNA COVID-19 vaccine. Data including demographics, symptoms, vital signs, ECG, echocardiography and cardiac enzymes were… Continue reading Cardiovascular Effects of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents
Covid-19: Regulators warn that rare Guillain-Barré cases may link to J&J and AstraZeneca vaccines
Rapid Response:Autoimmune damage to the nerves following Covid vaccines: EMA issued warning to patients and healthcare professionalsDear EditorEMA recently investigated the cases of Guillain-Barre syndrome (GBS) following Covid vaccine AstraZeneca (AZ) and have issued a warning to raise awareness of healthcare professionals and the public about GBS cases following Covid vaccinations and recommended revising the… Continue reading Covid-19: Regulators warn that rare Guillain-Barré cases may link to J&J and AstraZeneca vaccines
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