OBJECTIVE: Identify the incidence and predictive factors for readmissions of elderly hospitalized with fractures.METHOD: Prospective cohort study on 376 elderly people from a trauma referral large hospital in central Brazil. Data were collected from medical records of elderly people with radiological diagnosis of fractures. Readmission that occurs up to one year after the first discharge… Continue reading Predictors of hospital readmission after fractures: One-year follow-up study
Category: Pneumology
Cannabis use and risks of respiratory and all-cause morbidity and mortality: a population-based, data-linkage, cohort study
Introduction Although cannabis is frequently used worldwide, its impact on respiratory health is characterised by controversy. Objective To evaluate the association between cannabis use and respiratory-related emergency room (ER) visits and hospitalisations. Methods A retrospective, population-based, cohort study was carried out, linking health survey and health administrative data for residents of Ontario, Canada, aged 12–65… Continue reading Cannabis use and risks of respiratory and all-cause morbidity and mortality: a population-based, data-linkage, cohort study
Prenatal antibiotic exposure, asthma and the atopic march: A systematic review and meta-analysis
BackgroundAntibiotic use during pregnancy may increase the risk for asthma in children. We performed a meta-analysis assessing prenatal antibiotic exposure and the risk for childhood wheeze or asthma, as well as for diseases associated with the atopic march. MethodsA systematic literature search protocol (PROSPERO-ID: CRD42020191940) was registered and searches were completed using Medline, Proquest, Embase,… Continue reading Prenatal antibiotic exposure, asthma and the atopic march: A systematic review and meta-analysis
Trajectories of asthma symptom presenting as wheezing and their associations with family environmental factors among children in Australia: evidence from a national birth cohort study
Objectives Asthma is one of the greatest health burdens, yet contributors to asthma symptom trajectories are understudied in Australian children. We aimed to assess the trajectories of asthma symptom and their associations with several family environmental factors during the childhood period in Australia. Design Secondary analysis from a cross-sequential cohort study. Setting Nationwide representative data… Continue reading Trajectories of asthma symptom presenting as wheezing and their associations with family environmental factors among children in Australia: evidence from a national birth cohort study
Steroid-induced fibroblast growth factors drive an epithelial-mesenchymal inflammatory axis in severe asthma
AbstractAsthma and inflammatory airway diseases restrict airflow in the lung, compromising gas exchange and lung function. Inhaled corticosteroids (ICSs) can reduce inflammation, control symptoms, and improve lung function; however, a growing number of patients with severe asthma do not benefit from ICS. Using bronchial airway epithelial brushings from patients with severe asthma or primary human… Continue reading Steroid-induced fibroblast growth factors drive an epithelial-mesenchymal inflammatory axis in severe asthma
Clustering of COPD patients and their response to pulmonary rehabilitation
Background and objectivePulmonary rehabilitation (PR) is fundamental in the management of chronic obstructive pulmonary disease (COPD). COPD patients show a large clinical heterogeneity that may influence their response to PR. Identification of homogeneous clusters of patients who may or may not respond to PR is important to personalize patient care. This study aimed at identifying… Continue reading Clustering of COPD patients and their response to pulmonary rehabilitation
COVID-19 Vaccine in Patients with Exacerbation of Idiopathic Pulmonary Fibrosis
To the editorBetween the end of 2020 and the beginning of 2021, the first mRNA vaccines against COVID-19 received approval for emergency use by the World Health Organization (WHO). Patientsaffected by fibrotic interstitial lung disease (ILD) were granted priority access to vaccination,as these patients may develop severe complications after SARS-CoV-2 infection and carry ahigher risk… Continue reading COVID-19 Vaccine in Patients with Exacerbation of Idiopathic Pulmonary Fibrosis
KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer
EP300, a transcription coactivator important in proliferation and differentiation, is frequently mutated in diverse cancer types, including small cell lung cancer (SCLC). While these mutations are thought to result in loss of EP300 function, the impact on tumorigenesis remains largely unknown. Here, we demonstrate that EP300 mutants lacking acetyltransferase domain accelerate tumor development in mouse… Continue reading KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer
Detection of microplastics in human lung tissue using μFTIR spectroscopy
AbstractAirborne microplastics (MPs) have been sampled globally, and their concentration is known to increase in areas of high human population and activity, especially indoors. Respiratory symptoms and disease following exposure to occupational levels of MPs within industry settings have also been reported. It remains to be seen whether MPs from the environment can be inhaled,… Continue reading Detection of microplastics in human lung tissue using μFTIR spectroscopy
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