Importance In the past 4 years, the American Cancer Society and the US Preventive Services Task Force updated recommendations to initiate colorectal cancer (CRC) screening at 45 years of age to address the increasing incidence of CRC among adults younger than 50 years. However, empirical evidence evaluating the potential benefits of screening in younger populations… Continue reading Age at Initiation of Lower Gastrointestinal Endoscopy and Colorectal Cancer Risk Among US Women
Category: Oncology
A retrospective observational study on cases of anaplastic brain tumors treated with the Di Bella Method: A rationale and effectiveness
AbstractDespite all the new developments in cancer therapy, the life expectancy of patients with malignant anaplastic brain tumors and glioblastoma multiform (GBM) remains short. Since the establishment of the Di Bella Method (DBM) in cancer therapy, DBM was able to increase the survival rate and life quality, without overt toxicity, in comparison to what is… Continue reading A retrospective observational study on cases of anaplastic brain tumors treated with the Di Bella Method: A rationale and effectiveness
Sodium accumulation in breast cancer predicts malignancy and treatment response
BackgroundBreast cancer remains a leading cause of death in women and novel imaging biomarkers are urgently required. Here, we demonstrate the diagnostic and treatment-monitoring potential of non-invasive sodium (23Na) MRI in preclinical models of breast cancer. MethodsFemale Rag2−/− Il2rg−/− and Balb/c mice bearing orthotopic breast tumours (MDA-MB-231, EMT6 and 4T1) underwent MRI as part of… Continue reading Sodium accumulation in breast cancer predicts malignancy and treatment response
KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer
EP300, a transcription coactivator important in proliferation and differentiation, is frequently mutated in diverse cancer types, including small cell lung cancer (SCLC). While these mutations are thought to result in loss of EP300 function, the impact on tumorigenesis remains largely unknown. Here, we demonstrate that EP300 mutants lacking acetyltransferase domain accelerate tumor development in mouse… Continue reading KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer
Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study
The food industry uses artificial sweeteners in a wide range of foods and beverages as alternatives to added sugars, for which deleterious effects on several chronic diseases are now well established. The safety of these food additives is debated, with conflicting findings regarding their role in the aetiology of various diseases. In particular, their carcinogenicity… Continue reading Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study
Clinically translatable cytokine delivery platform for eradication of intraperitoneal tumors
AbstractProinflammatory cytokines have been approved by the Food and Drug Administration for the treatment of metastatic melanoma and renal carcinoma. However, effective cytokine therapy requires high-dose infusions that can result in antidrug antibodies and/or systemic side effects that limit long-term benefits. To overcome these limitations, we developed a clinically translatable cytokine delivery platform composed of… Continue reading Clinically translatable cytokine delivery platform for eradication of intraperitoneal tumors
MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding
MYC's role in promoting tumorigenesis is beyond doubt, but its function in the metastatic process is still controversial. Omomyc is a MYC dominant negative that has shown potent antitumor activity in multiple cancer cell lines and mouse models, regardless of their tissue of origin or driver mutations, by impacting on several of the hallmarks of… Continue reading MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding
Prospective Analyses of Sedentary Behavior in Relation to Risk of Ovarian Cancer
To examine the association of sedentary behavior with risk of ovarian cancer overall, by tumor subtype, and by participant characteristics in the Nurses’ Health Study (NHS) and NHSII. A total of 69,558 NHS (1992-2016) and 104,130 NHSII (1991-2015) participants were included in analysis who reported sitting time at home, work, and watching television, which included… Continue reading Prospective Analyses of Sedentary Behavior in Relation to Risk of Ovarian Cancer
Risk of cancer in regular and low meat-eaters, fish-eaters, and vegetarians: a prospective analysis of UK Biobank participants
Following a vegetarian diet has become increasingly popular and some evidence suggests that being vegetarian may be associated with a lower risk of cancer overall. However, for specific cancer sites, the evidence is limited. Our aim was to assess the associations of vegetarian and non-vegetarian diets with risks of all cancer, colorectal cancer, postmenopausal breast… Continue reading Risk of cancer in regular and low meat-eaters, fish-eaters, and vegetarians: a prospective analysis of UK Biobank participants
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