..The World Cancer Research Fund (WCRF) 2007 stated that the consumption of processed meat is a convincing cause of colorectal cancer (CRC), and therefore, the public should avoid it entirely. Sodium nitrite has emerged as a putative candidate responsible for the CRC-inducing effects of processed meats. Sodium nitrite is purported to prevent the growth of… Continue reading A Review of the In Vivo Evidence Investigating the Role of #Nitrite Exposure from Processed Meat Consumption in the Development of Colorectal #cancer
Category: Oncology
Sustained #weight loss and risk of #breast cancer in women ≥50 years: a pooled analysis of prospective data
..Compared with women with stable weight (± 2kg), women with sustained weight loss had a lower risk of breast cancer. This risk reduction was linear and specific to women not using postmenopausal hormones (>2-4.5kg lost: Hazard Ratio (HR)= 0.82, 95% confidence interval (CI): 0.70-0.96; >4.5-<9kg lost: HR = 0.75, 95% CI: 0.63-0.90; ≥9kg lost: HR = 0.68, 95% CI:… Continue reading Sustained #weight loss and risk of #breast cancer in women ≥50 years: a pooled analysis of prospective data
Association of Indoor #Tanning Exposure With Age at #Melanoma Diagnosis and BRAF V600E Mutations
..The 114 patients who reported indoor tanning exposure were younger at diagnosis than the 222 patients who did not (51.5 vs 64.0 years, two-sided P < .001). BRAF V600E genotype was more prevalent in ever-users than in nonusers (42.9% vs 28.3%, two-sided P = .04) and higher in ever-users who initiated indoor tanning prior to age… Continue reading Association of Indoor #Tanning Exposure With Age at #Melanoma Diagnosis and BRAF V600E Mutations
Use of #anastrozole for #breast cancer prevention (IBIS-II): long-term results of a randomised controlled trial
..3864 women were recruited between Feb 2, 2003, and Jan 31, 2012. 1920 women were randomly assigned to 5 years anastrozole and 1944 to placebo. After a median follow-up of 131 months (IQR 105–156), a 49% reduction in breast cancer was observed for anastrozole (85 vs 165 cases, hazard ratio [HR] 0·51, 95% CI 0·39–0·66,… Continue reading Use of #anastrozole for #breast cancer prevention (IBIS-II): long-term results of a randomised controlled trial
Association Between #Marijuana Use and Risk of #Cancer A Systematic Review and Meta-analysis
.. In pooled analysis of case-control studies, ever use of marijuana was not associated with head and neck squamous cell carcinoma or oral cancer. In pooled analysis of 3 case-control studies, more than 10 years of marijuana use (joint-years not reported) was associated with TGCT (OR, 1.36; 95% CI, 1.03-1.81; P = .03; I2 = 0%) and nonseminoma TGCT… Continue reading Association Between #Marijuana Use and Risk of #Cancer A Systematic Review and Meta-analysis
Precipitation and #Climate Zone Explains the Geographical Disparity in the Invasive #Cancer Incidence Rates in the United States
Environmental factors such as ultraviolet radiation and pollution have been known to influence the incidence rate of cancer. However, these factors do not explain the variation in incidence rates across the United States.. ..Precipitation and climate zone were included in each model along with demographic variables such as annual income, population by gender, race, and… Continue reading Precipitation and #Climate Zone Explains the Geographical Disparity in the Invasive #Cancer Incidence Rates in the United States
Family history of #cancer and subsequent risk of cancer: A large‐scale population‐based prospective study in Japan
Family history (FH) of cancer is an important factor of increased risk of several cancers.. During 1,802,581 person‐years of follow‐up, a total of 16,336 newly diagnosed cancers were identified. Any site (Hazard ratios = 1.11 (95% confidence interval = 1.07–1.15]), esophagus (2.11 [1.00–4.45]), stomach (1.36 [1.19–1.55]), liver (1.69 [1.10–2.61]), pancreas (2.63 [1.45–4.79]), lung (1.51 [1.14–2.00]),… Continue reading Family history of #cancer and subsequent risk of cancer: A large‐scale population‐based prospective study in Japan
Cleveland Clinic Unveils Top 10 Medical #Innovations for 2020
1. Dual-Acting Osteoporosis Drug 2. Expanded Use of Minimally Invasive Mitral Valve Surgery 3. Inaugural Treatment for Transthyretin Amyloid Cardiomyopathy 4. Therapy for Peanut Allergies 5. Closed-Loop Spinal Cord Stimulation 6. Biologics in Orthopaedic Repair 7. Antibiotic Envelope for Cardiac Implantable Device Infection Prevention 8. Bempedoic Acid for Cholesterol Lowering in Statin Intolerant Patients 9.… Continue reading Cleveland Clinic Unveils Top 10 Medical #Innovations for 2020
Vitamin #D-VDR signaling inhibits Wnt/beta-catenin-mediated #melanoma progression and promotes anti-tumor immunity
..1α,25-dihydroxyvitamin D3 signals via the Vitamin D Receptor (VDR). Higher serum vitamin D is associated with thinner primary melanoma and better outcome, although a causal mechanism has not been established. As melanoma patients commonly avoid sun exposure, and consequent vitamin D deficiency might worsen outcomes, we interrogated 703 primary melanoma transcriptomes to understand the role… Continue reading Vitamin #D-VDR signaling inhibits Wnt/beta-catenin-mediated #melanoma progression and promotes anti-tumor immunity
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