Importance The association between glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) and risk of Alzheimer disease and related dementias (ADRD) remains to be confirmed.Objective To assess the risk of ADRD associated with GLP-1RAs and SGLT2is in people with type 2 diabetes (T2D).Design, Setting, and Participants This target trial emulation study used electronic… Continue reading GLP-1RA and SGLT2i Medications for Type 2 #Diabetes and #Alzheimer Disease and Related Dementias
Category: Neurology
Marital status and risk of #dementia over 18 years: Surprising findings from the National Alzheimer’s Coordinating Center
Marital status is a potential risk/protective factor for adverse health outcomes. This study tested whether marital status was associated with dementia risk in older adults.METHODSParticipants (N = 24,107; Meanage = 71.79) were from the National Alzheimer's Coordinating Center. Cox regressions tested the association between baseline marital status and clinically ascertained dementia over up to 18… Continue reading Marital status and risk of #dementia over 18 years: Surprising findings from the National Alzheimer’s Coordinating Center
Lower slow wave #sleep and rapid eye movement sleep are associated with brain #atrophy of AD-vulnerable regions
Study Objectives:Sleep deficiency is associated with Alzheimer’s disease (AD) pathogenesis. We examined the association of sleep architecture with anatomical features observed in AD: (1) atrophy of hippocampus, entorhinal, inferior parietal, parahippocampal, precuneus, and cuneus regions (“AD-vulnerable regions”) and (2) cerebral microbleeds.Methods:In 270 participants of the Atherosclerosis Risk in the Communities Study, we examined the association… Continue reading Lower slow wave #sleep and rapid eye movement sleep are associated with brain #atrophy of AD-vulnerable regions
#Metal Concentrations in #Blood and #Cerebrospinal Fluid of Patients With #Arthroplasty Implants
Key PointsQuestion Do patients with large joint replacements have elevated levels of arthroplasty-relevant metals in blood and cerebrospinal fluid (CSF)?Findings This cross-sectional study with 204 patients found blood levels of cobalt, chromium, titanium, niobium, and zirconium to be significantly higher in patients with large joint replacements compared with arthroplasty-naive control participants. Cobalt levels in CSF… Continue reading #Metal Concentrations in #Blood and #Cerebrospinal Fluid of Patients With #Arthroplasty Implants
Five-Year Changes in 24-Hour #Sleep-Wake Activity and #Dementia Risk in Oldest Old Women
AbstractBackground and ObjectivesSleep disruptions are associated with cognitive aging in older adults. However, little is known about longitudinal sleep changes in the oldest old and whether these changes are linked to cognitive impairment. We aimed to determine whether changes in 24-hour multidimensional sleep-wake activity are associated with mild cognitive impairment (MCI) and dementia in oldest… Continue reading Five-Year Changes in 24-Hour #Sleep-Wake Activity and #Dementia Risk in Oldest Old Women
Reversible reduction in brain #myelin content upon #marathon running
Here we use magnetic resonance imaging to study the impact of marathon running on brain structure in humans. We show that the signal for myelin water fraction—a surrogate of myelin content—is substantially reduced upon marathon running in specific brain regions involved in motor coordination and sensory and emotional integration, but recovers within two months. These… Continue reading Reversible reduction in brain #myelin content upon #marathon running
#Sleep selectively and durably enhances #memory for the sequence of real-world experiences
Sleep is thought to play a critical role in the retention of memory for past experiences (episodic memory), reducing the rate of forgetting compared with wakefulness. Yet it remains unclear whether and how sleep actively transforms the way we remember multidimensional real-world experiences, and how such memory transformation unfolds over the days, months and years… Continue reading #Sleep selectively and durably enhances #memory for the sequence of real-world experiences
The Impact of Gut #Microbiota on the Development of #Anxiety Symptoms—A Narrative Review
The gut microbiota plays a key role in mental health, with growing evidence linking its composition to anxiety and depressive disorders. Research on this topic has expanded significantly in recent years. This review explores alterations in the gut microbiota of individuals with anxiety disorders and examines the potential therapeutic effects of probiotics. Background/Objectives: This review… Continue reading The Impact of Gut #Microbiota on the Development of #Anxiety Symptoms—A Narrative Review
Human #microplastic removal: what does the evidence tell us?
The increased levels of microplastics and nanoplastics (MNPs) found in human brain tissue are alarming, particularly in patients with dementia. Although total avoidance of MNP exposure will likely remain an unattainable endpoint in light of their ubiquity in the environment, new studies indicate feasible pathways by which dietary intake may be decreased or clearances improved.… Continue reading Human #microplastic removal: what does the evidence tell us?
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