Key PointsQuestion Do patients with large joint replacements have elevated levels of arthroplasty-relevant metals in blood and cerebrospinal fluid (CSF)?Findings This cross-sectional study with 204 patients found blood levels of cobalt, chromium, titanium, niobium, and zirconium to be significantly higher in patients with large joint replacements compared with arthroplasty-naive control participants. Cobalt levels in CSF… Continue reading #Metal Concentrations in #Blood and #Cerebrospinal Fluid of Patients With #Arthroplasty Implants
Category: Neurology
Five-Year Changes in 24-Hour #Sleep-Wake Activity and #Dementia Risk in Oldest Old Women
AbstractBackground and ObjectivesSleep disruptions are associated with cognitive aging in older adults. However, little is known about longitudinal sleep changes in the oldest old and whether these changes are linked to cognitive impairment. We aimed to determine whether changes in 24-hour multidimensional sleep-wake activity are associated with mild cognitive impairment (MCI) and dementia in oldest… Continue reading Five-Year Changes in 24-Hour #Sleep-Wake Activity and #Dementia Risk in Oldest Old Women
Reversible reduction in brain #myelin content upon #marathon running
Here we use magnetic resonance imaging to study the impact of marathon running on brain structure in humans. We show that the signal for myelin water fraction—a surrogate of myelin content—is substantially reduced upon marathon running in specific brain regions involved in motor coordination and sensory and emotional integration, but recovers within two months. These… Continue reading Reversible reduction in brain #myelin content upon #marathon running
#Sleep selectively and durably enhances #memory for the sequence of real-world experiences
Sleep is thought to play a critical role in the retention of memory for past experiences (episodic memory), reducing the rate of forgetting compared with wakefulness. Yet it remains unclear whether and how sleep actively transforms the way we remember multidimensional real-world experiences, and how such memory transformation unfolds over the days, months and years… Continue reading #Sleep selectively and durably enhances #memory for the sequence of real-world experiences
The Impact of Gut #Microbiota on the Development of #Anxiety Symptoms—A Narrative Review
The gut microbiota plays a key role in mental health, with growing evidence linking its composition to anxiety and depressive disorders. Research on this topic has expanded significantly in recent years. This review explores alterations in the gut microbiota of individuals with anxiety disorders and examines the potential therapeutic effects of probiotics. Background/Objectives: This review… Continue reading The Impact of Gut #Microbiota on the Development of #Anxiety Symptoms—A Narrative Review
Human #microplastic removal: what does the evidence tell us?
The increased levels of microplastics and nanoplastics (MNPs) found in human brain tissue are alarming, particularly in patients with dementia. Although total avoidance of MNP exposure will likely remain an unattainable endpoint in light of their ubiquity in the environment, new studies indicate feasible pathways by which dietary intake may be decreased or clearances improved.… Continue reading Human #microplastic removal: what does the evidence tell us?
Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to #Dementia Risk
BackgroundNon-steroidal anti-inflammatory (NSAID) medication could reduce dementia risk due to anti-inflammatory and possibly amyloid-lowering properties. However, the results of observational studies and short-term randomized-controlled trials have been inconsistent, and duration and dose–response relationships are still unclear.MethodsWe included 11,745 dementia-free participants from the prospective population-based Rotterdam Study (59.5% female, mean age 66.2 years). NSAID use from 1991… Continue reading Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to #Dementia Risk
Association of #Diet and #Waist-to-Hip Ratio With Brain Connectivity and #Memory in #Aging
Importance Epidemiological studies suggest that lifestyle factors are associated with risk of dementia. However, few studies have examined the association of diet and waist to hip ratio (WHR) with hippocampus connectivity and cognitive health.Objective To ascertain how longitudinal changes in diet quality and WHR during midlife are associated with hippocampal connectivity and cognitive function in… Continue reading Association of #Diet and #Waist-to-Hip Ratio With Brain Connectivity and #Memory in #Aging
#Cognitive Decline After First-Time Transient #Ischemic Attack
Question When controlling for vascular and demographic factors, does transient ischemic attack confer an independent risk for cognitive decline?Findings In this longitudinal cohort study (Reasons for Geographic and Racial Differences in Stroke [REGARDS]), pre-event and postevent cognitive trajectories were compared in 356 individuals with TIA, 965 individuals with stroke, and 14 882 asymptomatic controls. A single,… Continue reading #Cognitive Decline After First-Time Transient #Ischemic Attack
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