BackgroundAlzheimer’s disease (AD) is a neurodegenerative disorder with increasing prevalence due to population aging. Eggs provide many nutrients important for brain health, including choline, omega-3 fatty acids, and lutein. Emerging evidence suggests that frequent egg consumption may improve cognitive performance on verbal tests, but whether consumption influences the risk of Alzheimer’s dementia and AD is… Continue reading Association of #Egg Intake With #Alzheimer’s #Dementia Risk in #Older Adults: The Rush #Memory and Aging Project
Category: Neurology
#AI -guided patient stratification improves outcomes and efficiency in the AMARANTH #Alzheimer’s Disease clinical trial
Alzheimer’s Disease (AD) drug discovery has been hampered by patient heterogeneity, and the lack of sensitive tools for precise stratification. Here, we demonstrate that our robust and interpretable AI-guided tool (predictive prognostic model, PPM) enhances precision in patient stratification, improving outcomes and decreasing sample size for a AD clinical trial. The AMARANTH trial of lanabecestat,… Continue reading #AI -guided patient stratification improves outcomes and efficiency in the AMARANTH #Alzheimer’s Disease clinical trial
Association between dietary #copper intake and #cognitive function in American older adults: NHANES 2011–2014
This cross-sectional observational study examined the association between dietary copper intake and cognitive function in American older adults, using data from the 2011 to 2014 National Health and Nutrition Examination Survey (NHANES). Analyzing a total of 2420 participants, dietary copper intake was determined by averaging two 24-h dietary recalls, whereas cognitive function was assessed by… Continue reading Association between dietary #copper intake and #cognitive function in American older adults: NHANES 2011–2014
Risk of #dementia following #gabapentin prescription in chronic low back #pain patients
Introduction Gabapentin is widely used to treat chronic pain, but its association with cognitive decline and dementia remains unclear. This study examined whether gabapentin prescription is associated with dementia in adults with chronic low back pain.Methods We conducted a retrospective cohort study using the TriNetX national database of de-identified patient records from 2004 to 2024.… Continue reading Risk of #dementia following #gabapentin prescription in chronic low back #pain patients
#Mind #Wandering during Implicit #Learning Is Associated with Increased Periodic #EEG Activity and Improved Extraction of Hidden Probabilistic Patterns
Mind wandering, occupying 30–50% of our waking time, remains an enigmatic phenomenon in cognitive neuroscience. A large number of studies showed a negative association between mind wandering and attention-demanding (model-based) tasks in both natural settings and laboratory conditions. Mind wandering, however, does not seem to be detrimental for all cognitive domains and was observed to… Continue reading #Mind #Wandering during Implicit #Learning Is Associated with Increased Periodic #EEG Activity and Improved Extraction of Hidden Probabilistic Patterns
#Ambroxol as a #Treatment for #Parkinson Disease #DementiaA Randomized Clinical Trial
Importance Carrying a variation in the gene for β-glucocerebrosidase is a major risk factor for Parkinson disease dementia (PDD), and raising β-glucocerebrosidase levels lowers α-synuclein in cell and animals. Ambroxol is a chaperone for β-glucocerebrosidase, which increases the levels of β-glucocerebrosidase.Objective To examine the safety and tolerability of ambroxol in PDD, test the efficacy of… Continue reading #Ambroxol as a #Treatment for #Parkinson Disease #DementiaA Randomized Clinical Trial
Your #Brain on ChatGPT: Accumulation of #Cognitive Debt when Using an #AI Assistant for Essay Writing Task
This study explores the neural and behavioral consequences of LLM-assisted essay writing. Participants were divided into three groups: LLM, Search Engine, and Brain-only (no tools). Each completed three sessions under the same condition. In a fourth session, LLM users were reassigned to Brain-only group (LLM-to-Brain), and Brain-only users were reassigned to LLM condition (Brain-to-LLM). A… Continue reading Your #Brain on ChatGPT: Accumulation of #Cognitive Debt when Using an #AI Assistant for Essay Writing Task
Active #Travel Mode and Incident #Dementia and #Brain Structure
Importance Active travel modes, such as walking and cycling, are feasible and readily embraced forms of physical activity, but their association with dementia risk and brain structure remains unclear.Objectives To investigate the long-term association between travel modes and dementia risk and brain structural metrics and to evaluate whether genetic predisposition could modify the association between… Continue reading Active #Travel Mode and Incident #Dementia and #Brain Structure
Contribution of Modifiable Midlife and Late-Life #Vascular Risk Factors to Incident #Dementia
Importance Midlife vascular risk factors are associated with an elevated risk of dementia. However, the total contribution of vascular risk factors in midlife and late life with incident dementia is uncertain.Objective To quantify the proportion of incident dementia attributable to modifiable vascular risk factors measured in midlife and late life and to examine differences by… Continue reading Contribution of Modifiable Midlife and Late-Life #Vascular Risk Factors to Incident #Dementia
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