As viable pharmacotherapies and blood biomarkers emerge for dementia treatment and screening, there remains a great need for accurate, sensitive biomarkers of cognitive function. We have previously demonstrated that Fastball, a new Electroencephalography (EEG) method for the passive and objective measurement of recognition memory that requires no behavioural memory response or task comprehension, is sensitive… Continue reading A passive and objective measure of recognition memory in mild #cognitive #impairment using Fastball #memory assessment
Category: Neurology
Association Between Consumption of Low- and No-Calorie Artificial #Sweeteners and #Cognitive DeclineAn 8-Year Prospective Study
Background and ObjectivesConsumption of low- and no-calorie sweeteners (LNCSs) has been associated with adverse health outcomes. However, little is known about the association between consumption of LNCSs and cognition. The aim of this study was to investigate the association between consumption of LNCSs and cognitive decline.MethodsWe conducted a longitudinal observational study using data from civil… Continue reading Association Between Consumption of Low- and No-Calorie Artificial #Sweeteners and #Cognitive DeclineAn 8-Year Prospective Study
#Retinal vascular dysfunction in the Mthfr677C>T mouse model of #cerebrovascular disease
INTRODUCTIONInvestigations of retinal biomarkers for #Alzheimer's disease (AD) and AD and related dementias (ADRD), has increased significantly. We examine retinal vascular health in a mouse containing the ADRD risk variant Mthfr677C>T to determine if changes in retina mirror similar changes in cerebrovasculature.METHODSMorphology and function of retinal vasculature and neurons were assessed using in vivo imaging,… Continue reading #Retinal vascular dysfunction in the Mthfr677C>T mouse model of #cerebrovascular disease
Fine-Tuning the Details: Post-encoding #Music Differentially Impacts General and Detailed #Memory
Music can effectively induce emotional arousal, which is associated with the release of stress hormones that are important for the emotional modulation of memory. Thus, music may serve as a powerful modulator of memory and mood, making it a promising therapeutic tool for memory and mood disorders such as Alzheimer's disease or depression. However, music's… Continue reading Fine-Tuning the Details: Post-encoding #Music Differentially Impacts General and Detailed #Memory
Decoding #memory function through naturalistic gaze patterns
#Eye movements are closely linked to encoding and retrieval processes, with changes in viewing behavior reflecting age- and pathology-related memory decline. In the current study, we leveraged this relationship to explore possible gaze-based indicators of memory function. Across two task-free viewing experiments, we investigated changes in naturalistic viewing behavior across five participant groups spanning a… Continue reading Decoding #memory function through naturalistic gaze patterns
Human #thalamocortical structural connectivity develops in line with a hierarchical axis of #cortical plasticity
Human cortical development follows a hierarchical, sensorimotor-to-association sequence. The brain’s capacity to enact this sequence indicates that it relies on unknown mechanisms to regulate regional differences in the timing of cortical maturation. Given evidence from animal systems that thalamic axons mechanistically regulate periods of cortical plasticity, here we evaluate in humans whether the development of… Continue reading Human #thalamocortical structural connectivity develops in line with a hierarchical axis of #cortical plasticity
#Electrophysiological correlates of dynamic #cycling in #Parkinson’s diseaseAuthor
Physical exercise like dynamic cycling has shown promise in enhancing motor function in Parkinson’s disease (PD). We examined the underlying mechanisms of dynamic cycling in PD, emphasizing its impact on the activity of the subthalamic nucleus (STN), a pivotal region within the basal ganglia.MethodsThe investigation involved 100 dynamic cycling sessions conducted among nine PD individuals.… Continue reading #Electrophysiological correlates of dynamic #cycling in #Parkinson’s diseaseAuthor
Phenome-wide Analysis of #Diseases in Relation to Objectively Measured #Sleep Traits and Comparison with Subjective Sleep Traits in 88,461 Adults
Background: Sleep traits have been suggested to correlate with various diseases, but most evidence is based on subjective sleep measurement. We investigated the associations of accelerometer-derived objective sleep traits with diseases throughout physiological systems to ascertain whether the disease spectrum related to objective sleep traits differs from that related to subjective sleep traits. Methods: In… Continue reading Phenome-wide Analysis of #Diseases in Relation to Objectively Measured #Sleep Traits and Comparison with Subjective Sleep Traits in 88,461 Adults
Time to Diagnosis in #Dementia: A Systematic Review With Meta-Analysis
Timely dementia diagnosis is a global priority, reflected in most national and regional policies and plans. Nevertheless, there are currently no robust estimates of the average time to diagnosis (TTD) and factors influencing diagnostic intervals. This article presents the first systematic review of quantitative studies on TTD in dementia and the factors associated with its… Continue reading Time to Diagnosis in #Dementia: A Systematic Review With Meta-Analysis
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