BACKGROUND: Acute disseminated encephalomyelitis (ADEM) is a disorder of the central nervous system which has been associated with preceding infection as well as vaccinations. We present a case of a 61-year-old woman with ADEM after receiving her initial vaccination for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This case highlights management of this acute… Continue reading Acute Disseminated Encephalomyelitis After SARS-CoV-2 Vaccination
Category: Neurology
The Periodontal Pathogen Fusobacterium nucleatum Exacerbates Alzheimer’s Pathogenesis via Specific Pathways
Alzheimer’s Disease (AD) is the most common form of dementia in older adults and has a devastating impact on the patient’s quality of life, which creates a significant socio-economic burden for the affected individuals and their families. In recent years, studies have identified a relationship between periodontitis and AD. Periodontitis is an infectious/inflammatory disease that… Continue reading The Periodontal Pathogen Fusobacterium nucleatum Exacerbates Alzheimer’s Pathogenesis via Specific Pathways
Acute ischemic stroke and vaccine-induced immune thrombotic thrombocytopenia post COVID-19 vaccination; a systematic review
AbstractIntroductionOne of the rare but potentially serious side effects of COVID-19 vaccination is arterial and venous thrombosis. Acute ischemic stroke (AIS) cases have been reported post COVID-19 vaccination. Herein, we systematically reviewed the reported cases of AIS after COVID-19 vaccination.MethodThis systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses… Continue reading Acute ischemic stroke and vaccine-induced immune thrombotic thrombocytopenia post COVID-19 vaccination; a systematic review
Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer’s disease among women
Variants in the tau gene (MAPT) region are associated with breast cancer in women and Alzheimer's disease (AD) among persons lacking apolipoprotein E ε4 (ε4–). MethodsTo identify novel genes associated with tau-related pathology, we conducted two genome-wide association studies (GWAS) for AD, one among 10,340 ε4– women in the Alzheimer's Disease Genetics Consortium (ADGC) and… Continue reading Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer’s disease among women
Tourism as a dementia treatment based on positive psychology
AbstractNo research in tourism or medicine has addressed the potential relationship between travel and the medical treatment of dementia. Given tourism's increasingly important role in society, a cross-disciplinary team of tourism and dementia experts provide insight into the potential benefits of tourism for individuals with dementia. This conceptual effort critically reviews the tourism and dementia… Continue reading Tourism as a dementia treatment based on positive psychology
Creutzfeldt-Jakob Disease After the COVID-19Vaccination
Reports of neurological problems are increasing for the clinical presentation of COVID-19 The clinical presentation reported in this study seemed to be a combination of nonspecificcomplications of the systemic disease, inflammation of the cerebrovascular system, and theeffects of a direct viral infection. Creutzfeldt–Jakob disease, a spongiform encephalopathycaused by prions, is characterized by a severe neurological… Continue reading Creutzfeldt-Jakob Disease After the COVID-19Vaccination
Passage of exogeneous fine particles from the lung into the brain in humans and animals
There are still significant knowledge gaps in understanding the intrusion and retention of exogeneous particles into the central nervous system (CNS). Here, we uncovered various exogeneous fine particles in human cerebrospinal fluids (CSFs) and identified the ambient environmental or occupational exposure sources of these particles, including commonly found particles (e.g., Fe- and Ca-containing ones) and… Continue reading Passage of exogeneous fine particles from the lung into the brain in humans and animals
Distressing dreams and risk of Parkinson’s disease: A population-based cohort study
BackgroundParkinson's disease (PD) is associated with alterations to the phenomenology of dreaming - including an increased frequency of distressing dreams. Whether distressing dreams may precede the development of PD is unknown. This study investigated the association between frequent distressing dreams and the risk of incident PD.Methods3818 men aged 67 years or older from the Osteoporotic… Continue reading Distressing dreams and risk of Parkinson’s disease: A population-based cohort study
Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model
Elevation of soluble wild-type (WT) tau occurs in synaptic compartments in Alzheimer’s disease. We addressed whether tau elevation affects synaptic transmission at the calyx of Held in slices from mice brainstem. Whole-cell loading of WT human tau (h-tau) in presynaptic terminals at 10–20 µM caused microtubule (MT) assembly and activity-dependent rundown of excitatory neurotransmission. Capacitance… Continue reading Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model
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