Persistent symptoms following SARS-CoV-2 infection are increasingly reported, although the drivers of post-acute sequelae (PASC) of COVID-19 are unclear. Here we assessed 214 individuals infected with SARS-CoV-2, with varying disease severity, for one year from COVID-19 symptom onset to determine the early correlates of PASC. A multivariate signature detected beyond two weeks of disease, encompassing… Continue reading #Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of #COVID-19
Category: Infectivology
#Autopsy findings in cases of fatal #COVID-19 #vaccine -induced #myocarditis
COVID-19 vaccines have been linked to myocarditis, which, in some circumstances, can be fatal. This systematic review aims to investigate potential causal links between COVID-19 vaccines and death from myocarditis using post-mortem analysis. We performed a systematic review of all published autopsy reports involving COVID-19 vaccination-induced myocarditis through 3 July 2023. All autopsy studies that… Continue reading #Autopsy findings in cases of fatal #COVID-19 #vaccine -induced #myocarditis
Short Oral Antibiotic Therapy for Pediatric Febrile #Urinary Tract Infections: A Randomized Trial
Febrile urinary tract infection (fUTI) in well-appearing children is conventionally treated with a standard 10-day course of oral antibiotic. The objective of this study is to determine the noninferiority (5% threshold) of a 5-day amoxicillin-clavulanate course compared with a 10-day regimen to treat fUTIs.METHODSThis is a multicenter, investigator-initiated, parallel-group, randomized, controlled trial. We randomly assigned… Continue reading Short Oral Antibiotic Therapy for Pediatric Febrile #Urinary Tract Infections: A Randomized Trial
Silver─Gallium Nano-Amalgamated Particles as a Novel, Biocompatible Solution for #Antibacterial Coatings
Bacterial infections account for countless deaths globally. Antibiotics are the primary countermeasure; however, the alarming spread of antibiotic-resistant strains necessitates alternative solutions. Silver and silver compounds have emerged as promising antibacterial agents. However, issues related to cytotoxicity and genotoxicity of silver remain concern. To overcome these challenges, this proposes an easy-to-control and straightforward method to… Continue reading Silver─Gallium Nano-Amalgamated Particles as a Novel, Biocompatible Solution for #Antibacterial Coatings
Elucidating regulatory processes of intense #physical activity by multi-omics analysis
BackgroundPhysiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations, such as firefighting, law enforcement, military, and sports. A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work environment.MethodsTo study regulatory processes in… Continue reading Elucidating regulatory processes of intense #physical activity by multi-omics analysis
Inability to work following #COVID-19 vaccination-a relevant aspect for future booster vaccinations
Objectives: COVID-19 vaccination is a key prevention strategy to reduce the spread and severity of SARS-CoV-2 infections. However, vaccine-related inability to work among healthcare workers (HCWs) could overstrain healthcare systems.Study design: The study presented was conducted as part of the prospective CoVacSer cohort study.Methods: This study examined sick leave and intake of pro re nata medication after the… Continue reading Inability to work following #COVID-19 vaccination-a relevant aspect for future booster vaccinations
#Covid symptoms follow a very distinctive #pattern now – as common signs change, doctors discover
IN a short space of just a few years, the symptoms of Covid have changed in some surprising ways. Doctors are finding signs of the diseases are now following a very distinctive pattern. How Covid symptoms are changing thanks to heard immunity from prior infections and vaccines The illness’ past telltale signs, like the loss… Continue reading #Covid symptoms follow a very distinctive #pattern now – as common signs change, doctors discover
Viruses Beyond the Villains: The Incredible World of Beneficial Viruses
Scientists have estimated the presence of a staggering 10 nonillion (10^31) viruses on our planet, a number that surpasses stars in the universe by a factor of 100 million. While viruses are often synonymous with illness and harm, their immense diversity hints at a much more complex narrative. Yes, viruses possess the extraordinary capability to… Continue reading Viruses Beyond the Villains: The Incredible World of Beneficial Viruses
Pitavastatin to Prevent Cardiovascular Disease in HIV Infection
The risk of cardiovascular disease is increased among persons with human immunodeficiency virus (HIV) infection, so data regarding primary prevention strategies in this population are needed.METHODSIn this phase 3 trial, we randomly assigned 7769 participants with HIV infection with a low-to-moderate risk of cardiovascular disease who were receiving antiretroviral therapy to receive daily pitavastatin calcium… Continue reading Pitavastatin to Prevent Cardiovascular Disease in HIV Infection
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