Severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) has led to the coronavirus disease 2019 (COVID–19) pandemic, severely affecting public health and the global economy.Adaptive immunity plays a crucial role in fighting against SARS–CoV–2 infection and directly in-fluences the clinical outcomes of patients. Clinical studies have indicated that patients with severeCOVID–19 exhibit delayed and weak adaptive… Continue reading SARS–CoV–2 #Spike Impairs #DNA Damage Repair and InhibitsV(D)J Recombination In Vitro
Category: Infectivology
#Zinc for the prevention or treatment of acute viral #respiratory tract infections in adults: a rapid systematic review and meta-analysis of randomised controlled trials
To evaluate the benefits and risks of zinc formulations compared with controls for prevention or treatment of acute viral respiratory tract infections (RTIs) in adults. Method Seventeen English and Chinese databases were searched in April/May 2020 for randomised controlled trials (RCTs), and from April/May 2020 to August 2020 for SARS-CoV-2 RCTs. Cochrane rapid review methods… Continue reading #Zinc for the prevention or treatment of acute viral #respiratory tract infections in adults: a rapid systematic review and meta-analysis of randomised controlled trials
Waning Immunity after the BNT162b2 #Vaccine in Israel
In December 2020, Israel began a mass vaccination campaign against coronavirus disease 2019 (Covid-19) by administering the BNT162b2 vaccine, which led to a sharp curtailing of the outbreak. After a period with almost no cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, a resurgent Covid-19 outbreak began in mid-June 2021. Possible reasons for… Continue reading Waning Immunity after the BNT162b2 #Vaccine in Israel
#Shedding of Infectious #SARS-CoV-2Despite Vaccination
The SARS-CoV-2 Delta variant might cause high viral loads, is highly transmissible, and containsmutations that confer partial immune escape 1,2. Outbreak investigations suggest that vaccinatedpersons can spread Delta 3,4. We compared RT-PCR cycle threshold (Ct) data from 699 swabspecimens collected in Wisconsin 29 June through 31 July 2021 and tested with a qualitative assay bya… Continue reading #Shedding of Infectious #SARS-CoV-2Despite Vaccination
Serum #procalcitonin levels associate with #Clostridioides difficile infection in patients with #inflammatory bowel disease
Clostridioides difficile infection (CDI) is a major cause of morbidity among patients with inflammatory bowel disease (IBD). Diagnostic biomarkers for early detection of CDI are needed in clinical practice. The relationship between serum procalcitonin and CDI in IBD patients has not been investigated so far. Therefore, we aimed to evaluate the usefulness of measuring serum… Continue reading Serum #procalcitonin levels associate with #Clostridioides difficile infection in patients with #inflammatory bowel disease
Early insight into #antibody-dependent enhancement after SARS-CoV-2 mRNA #vaccination
Current vaccines, which induce a B-cell-mediated antibody response against the spike protein of SARS-CoV-2, have markedly reduced infection rates. However, the emergence of new variants as a result of SARS-CoV-2 evolution requires the development of novel vaccines that are T-cell-based and that target mutant-specific spike proteins along with ORF1ab or nucleocapsid protein. This approach is… Continue reading Early insight into #antibody-dependent enhancement after SARS-CoV-2 mRNA #vaccination
Association of #Statins and 28-Day Mortality in Patients Hospitalized with #SARS CoV-2 Infection
Statins may be protective in SARS-CoV-2 infection. The aim of this study was to evaluate the effect of in-hospital statin use on 28-day mortality and ICU admission among patients with SARS-CoV-2 stratified into 4 groups: those who used statins prior to hospitalization (continued, discontinued) and those who did not (newly initiated, never). MethodsIn a cohort… Continue reading Association of #Statins and 28-Day Mortality in Patients Hospitalized with #SARS CoV-2 Infection
All-cause and cause-specific mortality in people with #mental disorders and intellectual disabilities, before and during the COVID-19 pandemic: cohort study
People with mental disorders and intellectual disabilities experience excess mortality compared with the general population. The impact of COVID-19 on exacerbating this, and in widening ethnic inequalities, is unclear. METHODSProspective data (N=167,122) from a large mental healthcare provider in London, UK, with deaths from 2019 to 2020, used to assess age- and gender-standardised mortality ratios… Continue reading All-cause and cause-specific mortality in people with #mental disorders and intellectual disabilities, before and during the COVID-19 pandemic: cohort study
#Heat stress and PPE during #COVID-19: impact on healthcare workers’ performance, safety and well-being in NHS settings
Personal protective equipment (PPE) can potentiate heat stress, which may have a negative impact on the wearer's performance, safety and well-being. In view of this, a survey was distributed to healthcare workers (HCWs) required to wear PPE during the coronavirus disease 2019 pandemic in the UK to evaluate perceived levels of heat stress and its… Continue reading #Heat stress and PPE during #COVID-19: impact on healthcare workers’ performance, safety and well-being in NHS settings
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