Question Does stereotactic body radiation therapy (SBRT) prior to systemic therapy improve overall survival compared with systemic therapy alone in patients with locally advanced hepatocellular carcinoma (HCC)?Findings This phase 3 randomized clinical trial found that the use of SBRT prior to sorafenib was associated with clinically important but not statistically significant improved overall survival in… Continue reading Stereotactic Body Radiotherapy vs #Sorafenib Alone in #Hepatocellular Carcinoma
Category: Hepatology
Screening for advanced #liver fibrosis due to metabolic dysfunction-associated #steatotic liver disease alongside #retina scanning in people with type 2 diabetes: a cross-sectional study
BackgroundInternational guidelines suggest screening for advanced fibrosis due to metabolic dysfunction-associated steatotic liver disease in people with type 2 diabetes, but how to implement these guidelines in clinical care remains unclear. We hypothesise that examination with VCTE could be implemented simultaneously with retina scanning with a high acceptance rate in people with type 2 diabetes.… Continue reading Screening for advanced #liver fibrosis due to metabolic dysfunction-associated #steatotic liver disease alongside #retina scanning in people with type 2 diabetes: a cross-sectional study
Distinct risk groups with different healthcare barriers and acute care use exist in the U.S. population with chronic #liver disease
BackgroundThe relationship between community-based healthcare barriers and risk of recurrent hospital-based care among persons with chronic liver disease (CLD) is understudied. We aimed to uncover distinct groups among adults in the United States with CLD based on healthcare barriers and risk-stratify recurrent acute care use by group.MethodsUsing National Health Interview Survey (2011 to 2017) data,… Continue reading Distinct risk groups with different healthcare barriers and acute care use exist in the U.S. population with chronic #liver disease
Estimated Exposure to 6 Potentially #Hepatotoxic Botanicals in US Adults
Importance Use of herbal and dietary supplements (HDSs) accounts for an increasing proportion of drug hepatotoxicity cases. Turmeric or curcumin, green tea extract, Garcinia cambogia, black cohosh, red yeast rice, and ashwagandha are the most frequently reported hepatoxic botanicals, but their prevalence and reasons for use in the general population are unknown.Objective To assess the prevalence and clinical… Continue reading Estimated Exposure to 6 Potentially #Hepatotoxic Botanicals in US Adults
Associations of #sex-related and #thyroid-related #hormones with risk of metabolic dysfunction-associated fatty #liver disease in T2DM patients
BackgroundWe aimed to examine sex-specific associations between sex- and thyroid-related hormones and the risk of metabolic dysfunction-associated fatty liver disease (MAFLD) in patients with type 2 diabetes mellitus (T2DM)MethodsCross-sectional analyses of baseline information from an ongoing cohort of 432 T2DM patients (185 women and 247 men) in Xiamen, China were conducted. Plasma sex-related hormones, including… Continue reading Associations of #sex-related and #thyroid-related #hormones with risk of metabolic dysfunction-associated fatty #liver disease in T2DM patients
Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty #liver disease
Acetyl-CoA synthetase short-chain family member 1 (ACSS1) uses acetate to generate mitochondrial acetyl-CoA and is regulated by deacetylation by sirtuin 3. We generated an ACSS1-acetylation (Ac) mimic mouse, where lysine-635 was mutated to glutamine (K635Q). Male Acss1K635Q/K635Q mice were smaller with higher metabolic rate and blood acetate and decreased liver/serum ATP and lactate levels. After a 48-hour… Continue reading Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty #liver disease
Dietary #Niacin Intake and Mortality Among Individuals With Nonalcoholic #Fatty #Liver Disease
Importance Evidence regarding the effect of dietary niacin intake on the risk of mortality among patients with nonalcoholic fatty liver disease (NAFLD) is scarce.Objective To examine the association of dietary niacin intake with all-cause mortality and cardiovascular disease (CVD) mortality among individuals with NAFLD.Design, Setting, and Participants This cohort study used data from the National Health and Nutrition… Continue reading Dietary #Niacin Intake and Mortality Among Individuals With Nonalcoholic #Fatty #Liver Disease
#Metformin and Its Benefits for Various Diseases
Metformin is a widely used biguanide drug due to its safety and low cost. It has been used for over 60 years to treat type 2 diabetes at the early stages because of its outstanding ability to decrease plasma glucose levels. Over time, different uses of metformin were discovered, and the benefits of metformin for… Continue reading #Metformin and Its Benefits for Various Diseases
Vitamin #E intake is inversely associated with #NAFLD measured by liver ultrasound transient elastography
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases, whose severe form is associated with oxidative stress. Vitamin E as an antioxidant has a protective potential in NAFLD. Whether dietary intake of vitamin E, supplementary vitamin E use, and total vitamin E have a preventive effect on NAFLD requires investigation.… Continue reading Vitamin #E intake is inversely associated with #NAFLD measured by liver ultrasound transient elastography
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