Administration of haploidentical donor natural killer (NK) cells, rituximab, and IL-2 to patients with non-Hodgkin lymphoma (NHL) has been shown to be safe, but the objective response rate was low, suggesting that further strategies to improve NK cell engraftment and function are needed. Here, Cichocki and colleagues showed that supplementation with nicotinamide during ex vivo… Continue reading #Nicotinamide enhances natural #killer cell function and yields remissions in patients with non-Hodgkin #lymphoma
Category: Hematology
Smart thrombosis inhibitors without bleeding side effects via charge tunable ligand design
Current treatments to prevent thrombosis, namely anticoagulants and platelets antagonists, remain complicated by the persistent risk of bleeding. Improved therapeutic strategies that diminish this risk would have a huge clinical impact. Antithrombotic agents that neutralize and inhibit polyphosphate (polyP) can be a powerful approach towards such a goal. Here, we report a design concept towards… Continue reading Smart thrombosis inhibitors without bleeding side effects via charge tunable ligand design
Prevalence of parvovirus B19 viraemia among German blood donations and the relationship to ABO and Rhesus blood group antigens
AbstractAsymptomatic blood donors can transmit human parvovirus B19 (B19V). We assessed the B19V prevalence amongst a large cohort of blood donations collected in Germany during 2015-2018. In total, 167,123 donations were screened for B19V DNA with 22 cases of viraemia identified (0.013% positive). Infections peaked at a four-year interval and the highest number of cases… Continue reading Prevalence of parvovirus B19 viraemia among German blood donations and the relationship to ABO and Rhesus blood group antigens
Simultaneous Occurrence of Immune-Mediated Thrombocytopenia and Myocarditis After mRNA-1273 COVID-19 Vaccination: A Case Report
Depressive disorders are associated with increased peripheral blood cell deformability: a cross-sectional case-control study (Mood-Morph)
Pathophysiological landmarks of depressive disorders are chronic low-grade inflammation and elevated glucocorticoid output. Both can potentially interfere with cytoskeleton organization, cell membrane bending and cell function, suggesting altered cell morpho-rheological properties like cell deformability and other cell mechanical features in depressive disorders. We performed a cross-sectional case-control study using the image-based morpho-rheological characterization of unmanipulated… Continue reading Depressive disorders are associated with increased peripheral blood cell deformability: a cross-sectional case-control study (Mood-Morph)
Managing bleeding risk after cold snare polypectomy in patients receiving direct-acting oral anticoagulants
Background and AimsThe best strategy to manage direct-acting oral anticoagulants (DOACs) for patients undergoing cold snare polypectomy remains unclear. This study compared the effect of continuing versus stopping DOACs only on the day of the procedure on bleeding after cold snare polypectomy. MethodsThis prospective, observational, single-center cohort study enrolled consecutive patients receiving antithrombotic agents and… Continue reading Managing bleeding risk after cold snare polypectomy in patients receiving direct-acting oral anticoagulants
Association of COVID-19 vaccines ChAdOx1 and BNT162b2 with major venous, arterial, or thrombocytopenic events: A population-based cohort study of 46 million adults in England
BackgroundThromboses in unusual locations after the Coronavirus Disease 2019 (COVID-19) vaccine ChAdOx1-S have been reported, although their frequency with vaccines of different types is uncertain at a population level. The aim of this study was to estimate the population-level risks of hospitalised thrombocytopenia and major arterial and venous thromboses after COVID-19 vaccination. Methods and findingsIn… Continue reading Association of COVID-19 vaccines ChAdOx1 and BNT162b2 with major venous, arterial, or thrombocytopenic events: A population-based cohort study of 46 million adults in England
Expected Viscosity After COVID-19 Vaccination, Hyperviscosity and Previous COVID-19
COVID-19 vaccine is the hope for containment of disease outbreak. The post vaccination adverse effect is an important consideration. The clot after vaccination is an emerging important clinical problem in some vaccine recipients.1 The cause of post vaccination blood clot is not known. It is proposed that the problem might be due to immunopathological process.2… Continue reading Expected Viscosity After COVID-19 Vaccination, Hyperviscosity and Previous COVID-19
Rapid Progression of Angioimmunoblastic T Cell Lymphoma Following BNT162b2 mRNA Vaccine Booster Shot: A Case Report
Since nucleoside-modified mRNA vaccines strongly activate T follicular helper cells, it is important to explore the possible impact of approved SARS-CoV-2 mRNA vaccines on neoplasms affecting this cell type. Herein, we report and discuss unexpected rapid progression of lymphomatous lesions after administration of a BNT162b2 mRNA vaccine booster in a man recently diagnosed with AITL.… Continue reading Rapid Progression of Angioimmunoblastic T Cell Lymphoma Following BNT162b2 mRNA Vaccine Booster Shot: A Case Report
2 Medical News 