Category: Hematology

Spatial organization of #protein aggregates on red #blood cells as physical biomarkers of #Alzheimer’s disease pathology

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Quantifying physical differences of protein aggregates implicated in Alzheimer’s disease (AD), in blood, could provide crucial information on disease stages. Here, red blood cells (RBCs) from 50 patients with neurocognitive complaints and 16 healthy individuals were profiled using an atomic force microscope (AFM). AFM measurements revealed patient age– and stage of neurocognitive disorder–dependent differences in… Continue reading Spatial organization of #protein aggregates on red #blood cells as physical biomarkers of #Alzheimer’s disease pathology

Long-Term Risk for Major #Bleeding During Extended Oral Anticoagulant Therapy for First Unprovoked Venous #Thromboembolism

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The long-term risk for major bleeding in patients receiving extended (beyond the initial 3 to 6 months) anticoagulant therapy for a first unprovoked venous thromboembolism (VTE) is uncertain. Purpose:To determine the incidence of major bleeding during extended anticoagulation of up to 5 years among patients with a first unprovoked VTE, overall, and in clinically important… Continue reading Long-Term Risk for Major #Bleeding During Extended Oral Anticoagulant Therapy for First Unprovoked Venous #Thromboembolism

Plasma Levels of #Homocysteine is Associated with Liver #Fibrosis in Health Check-Up Population

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Studies have shown a link between homocysteine (Hcy) and heart diseases, kidney diseases, cerebrovascular diseases, liver diseases, and other pathological conditions. However, the relationship between Hcy and liver fibrosis (LF) is unclear. Here, we studied the link between plasma Hcy concentration and LF. Methods: We determined and recorded the plasma Hcy concentration, general biochemical parameters,… Continue reading Plasma Levels of #Homocysteine is Associated with Liver #Fibrosis in Health Check-Up Population

#Cerebral venous #thrombosis after vaccination against #COVID-19 in the UK: a multicentre cohort study

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A new syndrome of vaccine-induced immune thrombotic thrombocytopenia (VITT) has emerged as a rare side-effect of vaccination against COVID-19. Cerebral venous thrombosis is the most common manifestation of this syndrome but, to our knowledge, has not previously been described in detail. We aimed to document the features of post-vaccination cerebral venous thrombosis with and without… Continue reading #Cerebral venous #thrombosis after vaccination against #COVID-19 in the UK: a multicentre cohort study

Prediction of #anemia and estimation of hemoglobin concentration using a smartphone #camera

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Anemia, defined as a low hemoglobin concentration, has a large impact on the health of the world’s population. We describe the use of a ubiquitous device, the smartphone, to predict hemoglobin concentration and screen for anemia. This was a prospective convenience sample study conducted in Emergency Department (ED) patients of an academic teaching hospital. In… Continue reading Prediction of #anemia and estimation of hemoglobin concentration using a smartphone #camera

#Erythrocyte adenosine A2B receptor prevents #cognitive and #auditory dysfunction by promoting hypoxic and metabolic reprogramming

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Hypoxia drives aging and promotes age-related cognition and hearing functional decline. Despite the role of erythrocytes in oxygen (O2) transport, their role in the onset of aging and age-related cognitive decline and hearing loss (HL) remains undetermined. Recent studies revealed that signaling through the erythrocyte adenosine A2B receptor (ADORA2B) promotes O2 release to counteract hypoxia… Continue reading #Erythrocyte adenosine A2B receptor prevents #cognitive and #auditory dysfunction by promoting hypoxic and metabolic reprogramming

Pathologic Antibodies to #Platelet Factor 4 after ChAdOx1 #nCoV-19 #Vaccination

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The mainstay of control of the coronavirus disease 2019 (Covid-19) pandemic is vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Within a year, several vaccines have been developed and millions of doses delivered. Reporting of adverse events is a critical postmarketing activity. METHODS We report findings in 23 patients who presented with thrombosis and… Continue reading Pathologic Antibodies to #Platelet Factor 4 after ChAdOx1 #nCoV-19 #Vaccination

American Society of Hematology 2021 guidelines for management of venous #thromboembolism: prevention and treatment in patients with #cancer

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Venous thromboembolism (VTE) is a common complication among patients with cancer. Patients with cancer and VTE are at a markedly increased risk for morbidity and mortality. Objective: These evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, clinicians, and other health care professionals in their decisions about the prevention and… Continue reading American Society of Hematology 2021 guidelines for management of venous #thromboembolism: prevention and treatment in patients with #cancer