Importance The gut-first hypothesis of Parkinson disease (PD) has gained traction, yet potential inciting events triggering Parkinson pathology from gut-related factors remain unclear. While Helicobacter pylori infection is linked to mucosal damage (MD) and PD, it is unknown how upper gastrointestinal MD from any source increases PD risk.Objective To evaluate any association between upper endoscopy findings of MD and… Continue reading Upper #Gastrointestinal Mucosal Damage and Subsequent Risk of #Parkinson Disease
Category: Gastroenterology
Comprehensive Association Analyses of Extraintestinal Manifestations in #Inflammatory Bowel Disease
Background & AimsPatients with inflammatory bowel disease (IBD) frequently develop extraintestinal manifestations (EIMs) that contribute substantially to morbidity. We assembled the largest multicohort data set to date to investigate the clinical, serologic, and genetic factors associated with EIM complications in IBD.MethodsData were available in 12,083 unrelated European ancestry IBD cases with presence or absence of… Continue reading Comprehensive Association Analyses of Extraintestinal Manifestations in #Inflammatory Bowel Disease
#Aspirin Use and Incidence of #Colorectal Cancer According to Lifestyle Risk
Importance Aspirin reduces the risk of colorectal cancer (CRC). Identifying individuals more likely to benefit from regular aspirin use for CRC prevention is a high priority.Objective To assess whether aspirin use is associated with the risk of CRC across different lifestyle risk factors.Design, Setting, and Participants A prospective cohort study among women in the Nurses’ Health Study (1980-2018)… Continue reading #Aspirin Use and Incidence of #Colorectal Cancer According to Lifestyle Risk
The central role of the gut #microbiota in the pathophysiology and management of type 2 #diabetes
The inhabitants of our intestines, collectively called the gut microbiome, comprise fungi, viruses, and bacterial strains. These microorganisms are involved in the fermentation of dietary compounds and the regulation of our adaptive and innate immune systems. Less known is the reciprocal interaction between the gut microbiota and type 2 diabetes mellitus (T2DM), as well as… Continue reading The central role of the gut #microbiota in the pathophysiology and management of type 2 #diabetes
Deep learning assists detection of #esophageal #cancer and precursor lesions in a prospective, randomized controlled study
Early-stage esophageal cancers show better treatment response but are harder to detect. Li et al. developed a deep learning pipeline to aid clinicians in identifying early-stage, high-risk esophageal lesions and tested it in a randomized clinical trial in patients undergoing endoscopy. Deep learning assistance doubled the detection of high-risk esophageal lesions compared with the unassisted control group.… Continue reading Deep learning assists detection of #esophageal #cancer and precursor lesions in a prospective, randomized controlled study
Impact of Plant-Based Dietary #Fibers on Metabolic Homeostasis in High-#Fat Diet Mice via Alterations in the Gut #Microbiota and Metabolites
BackgroundThe gut microbiota contributes to metabolic disease, and diet shapes the gut microbiota, emphasizing the need to better understand how diet impacts metabolic disease via gut microbiota alterations. Fiber intake is linked with improvements in metabolic homeostasis in rodents and humans, which is associated with changes in the gut microbiota. However, dietary fiber is extremely… Continue reading Impact of Plant-Based Dietary #Fibers on Metabolic Homeostasis in High-#Fat Diet Mice via Alterations in the Gut #Microbiota and Metabolites
The association between dietary vitamin #B1 intake and #constipation: a population-based study
BackgroundNumerous researches have indicated a correlation between the intake of dietary micronutrients and the occurrence of constipation. Nevertheless, the correlation between constipation and vitamin B1 remains uninvestigated. The main aim of this research was to examine the association between chronic constipation and the consumption of vitamin B1 in the diet among adult participants of the… Continue reading The association between dietary vitamin #B1 intake and #constipation: a population-based study
Prevalence of #irritable bowel syndrome and functional $dyspepsia after acute #gastroenteritis: systematic review and meta-analysis
Objective Disorders of gut-brain interaction may arise after acute gastroenteritis. Data on the influence of pathogen type on the risk of postinfection IBS (PI-IBS), as on postinfection functional dyspepsia (PI-FD), are limited. We conducted a systematic review and meta-analysis to determine prevalence of PI-IBS or PI-FD after acute gastroenteritis.Design We included observational studies recruiting ≥50 adults and… Continue reading Prevalence of #irritable bowel syndrome and functional $dyspepsia after acute #gastroenteritis: systematic review and meta-analysis
Quantified Metrics of #Gastric Emptying Delay by #Glucagon-Like Peptide-1 Agonists: A Systematic Review and Meta-Analysis With Insights for Periprocedural Management
INTRODUCTION: Divergent recommendations for periprocedural management of glucagon-like peptide-1 (GLP-1) receptor agonist (GLP-1 RA) medications rely on limited evidence. We performed a systematic review and meta-analysis to provide quantitative measures of gastric emptying relevant to mechanisms of weight loss and to periprocedural management of GLP-1 RA. We hypothesized that the magnitude of gastric emptying delay would… Continue reading Quantified Metrics of #Gastric Emptying Delay by #Glucagon-Like Peptide-1 Agonists: A Systematic Review and Meta-Analysis With Insights for Periprocedural Management
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