We have shown that combination treatment with decaffeinated green tea extract (GTE) and voluntary exercise (Ex) reduces obesity and insulin resistance in high-fat (HF)-fed mice to a greater extent than either treatment alone. Here, we investigated the effects of GTE-, Ex- or the combination on the development of obesity-related NAFLD.. ..Combination treated, but not singly… Continue reading Mitigation of nonalcoholic #fatty liver disease in high-fat-fed mice by the combination of decaffeinated green tea extract and voluntary exercise
Category: Gastroenterology
#Nut Consumption and Risk of #Cancer: A Meta-analysis of Prospective Studies
..When comparing the highest with the lowest category of nut intake, high consumption of nuts was significantly associated with decreased risk of overall cancer (RR = 0.90; 95% CI, 0.85–0.95). The protective effect of nut consumption was especially apparent against cancers from the digestive system (RR = 0.83; 95% CI, 0.77–0.89). Among different nut classes,… Continue reading #Nut Consumption and Risk of #Cancer: A Meta-analysis of Prospective Studies
Unresolved issues of immune tolerance in chronic hepatitis #B
During the natural course of chronic hepatitis B virus infection, immune-tolerant phase is characterized by high viral replication, the presence of HBV e antigen (HBeAg), and normal or minimally elevated serum alanine aminotransferase. Immune-tolerant phase is usually regarded as a benign course of the disease. International guidelines recommend observation rather than treatment during immune-tolerant phase.… Continue reading Unresolved issues of immune tolerance in chronic hepatitis #B
Adrenergic Signaling in #Muscularis Macrophages Limits Infection-Induced Neuronal Loss
..Enteric-associated neurons (EANs) are closely associated with immune cells and continuously monitor and modulate homeostatic intestinal functions, including motility and nutrient sensing. Bidirectional interactions between neuronal and immune cells are altered during disease processes such as neurodegeneration or #irritable bowel syndrome. We investigated the effects of infection-induced inflammation on intrinsic EANs (iEANs) and the role… Continue reading Adrenergic Signaling in #Muscularis Macrophages Limits Infection-Induced Neuronal Loss
T cell receptor cross-reactivity between gliadin and #bacterial peptides in #celiac disease
The human leukocyte antigen (HLA) locus is strongly associated with T cell-mediated autoimmune disorders. HLA-DQ2.5-mediated celiac disease (CeD) is triggered by the ingestion of gluten, although the relative roles of genetic and environmental risk factors in CeD is unclear. Here we identify microbially derived mimics of gliadin epitopes and a parental bacterial protein that is… Continue reading T cell receptor cross-reactivity between gliadin and #bacterial peptides in #celiac disease
Gastrointestinal #bleeding prophylaxis for critically #ill patients: a clinical practice guideline
Long-term benefit of #Microbiota Transfer Therapy on #autism symptoms and gut microbiota
Many studies have reported abnormal gut microbiota in individuals with Autism Spectrum Disorders (ASD), suggesting a link between gut microbiome and autism-like behaviors. Modifying the gut microbiome is a potential route to improve gastrointestinal (GI) and behavioral symptoms in children with ASD, and fecal microbiota transplant could transform the dysbiotic gut microbiome toward a healthy… Continue reading Long-term benefit of #Microbiota Transfer Therapy on #autism symptoms and gut microbiota
Association Between #Beverage Intake and Incidence of Gastroesophageal #Reflux Symptoms
..Patients are frequently advised to eliminate coffee, tea, and/or soda to reduce symptoms of gastroesophageal reflux (GER), such as heartburn or regurgitation. ..After multivariable adjustment, hazard ratios (HRs) for women with the highest intake of each beverage (more than 6 servings/day) compared to women with the lowest intake (0 servings/day) were 1.34 for coffee (95%… Continue reading Association Between #Beverage Intake and Incidence of Gastroesophageal #Reflux Symptoms
Association Between Acute #Gastroenteritis and Continuous Use of Proton Pump Inhibitors During Winter Periods of Highest Circulation of Enteric Viruses
An increased risk of acute bacterial enteric infections has been reported among patients receiving proton pump inhibitor (#PPI) therapy. The risk of acute gastroenteritis (AGE) of viral origin associated with continuous PPI exposure has been less studied ..At least 1 AGE epidemic episode was identified in 3131 patients (1.3%) receiving PPI therapy and in 4327… Continue reading Association Between Acute #Gastroenteritis and Continuous Use of Proton Pump Inhibitors During Winter Periods of Highest Circulation of Enteric Viruses
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