Hepatocellular carcinoma (HCC) risk persists after hepatitis C virus (HCV) eradication with direct‐acting antivirals (DAAs), particularly in patients with cirrhosis. Identifying those who are likely to develop HCC is a critical unmet medical need. Our aim is to develop a score that offers individualized patient HCC risk prediction.. ..In the derivation cohort, the median follow‐up… Continue reading GES: A validated simple score to predict the risk of #HCC in patients with #HCV‐GT4‐associated advanced liver fibrosis after oral antivirals
Category: Gastroenterology
Inadequate #Physical Activity and #Sedentary Behavior Are Independent Predictors of Nonalcoholic Fatty #Liver Disease
In general, physical activity (PA) and nonalcoholic fatty liver disease (NAFLD) have an inverse association. However, studies assessing the impact of the widely accepted Physical Activity Guidelines for Americans (PA Guidelines) on NAFLD are lacking. We performed a serial, cross‐sectional analysis among adults by using the 2007‐2016 US National Health and Nutrition Examination Survey. NAFLD… Continue reading Inadequate #Physical Activity and #Sedentary Behavior Are Independent Predictors of Nonalcoholic Fatty #Liver Disease
Linked Color Imaging Focused on Neoplasm Detection in the Upper Gastrointestinal Tract
Linked color imaging (LCI) is a new image-enhanced endoscopy technique that allows users to recognize slight differences in mucosal color To compare the performance of LCI with white light imaging (WLI) in detecting neoplastic lesions in the upper gastrointestinal tract.. ..752 patients were assigned to the WLI group and 750 to the LCI group. The… Continue reading Linked Color Imaging Focused on Neoplasm Detection in the Upper Gastrointestinal Tract
The #triglyceride- #glucose index is associated with the severity of hepatic #steatosis and the presence of liver #fibrosis in non-alcoholic fatty liver disease: a cross-sectional study in Chinese adults
The triglyceride-glucose index (TyG) is a reliable predictor of non-alcoholic fatty liver disease (NAFLD). Its association with the severity of hepatic steatosis and liver fibrosis in NAFLD is poorly understood. This study evaluated the relationship between these factors in NAFLD. ..The TyG index was significantly correlated with the severity of hepatic steatosis and the presence… Continue reading The #triglyceride- #glucose index is associated with the severity of hepatic #steatosis and the presence of liver #fibrosis in non-alcoholic fatty liver disease: a cross-sectional study in Chinese adults
Dietary #Fructose Alters the Composition, Localization and Metabolism of Gut #Microbiota in Association with Worsening #Colitis
The incidence of inflammatory bowel diseases has increased over the last half century, suggesting a role for dietary factors. Fructose consumption has increased in recent years. Recently, a high fructose diet (HFrD) was shown to enhance DSS-induced colitis in mice. The primary objectives of the current study were to elucidate the mechanism(s) underlying the pro-colitic… Continue reading Dietary #Fructose Alters the Composition, Localization and Metabolism of Gut #Microbiota in Association with Worsening #Colitis
Association Between Time to Colonoscopy after Positive Fecal Testing and Colorectal Cancer Outcomes: a Systematic Review
Colonoscopy is required following a positive fecal screening test for colorectal cancer (CRC). It remains unclear to what extent time to colonoscopy is associated with CRC-related outcomes. We performed a systematic review to elucidate this relationship.. ..From 1,612 initial studies, 8 were included in the systematic review, with 5 reporting outcomes for FIT. Although meta-analysis… Continue reading Association Between Time to Colonoscopy after Positive Fecal Testing and Colorectal Cancer Outcomes: a Systematic Review
Fecal #Microbiota Transplant is Highly Effective in Real-World Practice: Initial Results from the FMT National Registry
Fecal microbiota transplantation (FMT) is commonly used for treatment of C. difficile infections (CDI), although prospective safety data are limited and real-world FMT practice and outcomes are not well described. The FMT National Registry was designed to assess FMT methods and both safety and effectiveness outcomes from North American FMT providers.. ..Of the first 259… Continue reading Fecal #Microbiota Transplant is Highly Effective in Real-World Practice: Initial Results from the FMT National Registry
#Bile Acids Signal via TGR5 to Activate #Intestinal Stem Cells and Epithelial Regeneration
Renewal and patterning of the intestinal epithelium is coordinated by intestinal stem cells (ISCs); dietary and metabolic factors provide signals to the niche that control ISC activity. Bile acids (BAs), metabolites in the gut, signal nutrient availability by activating the G protein-coupled bile acid receptor 1 (GPBAR1, also called TGR5). TGR5 is expressed in the… Continue reading #Bile Acids Signal via TGR5 to Activate #Intestinal Stem Cells and Epithelial Regeneration
Association of #Coffee Intake With Survival in Patients With Advanced or Metastatic #Colorectal Cancer
Several compounds found in coffee possess antioxidant, anti-inflammatory, and insulin-sensitizing effects, which may contribute to anticancer activity. Epidemiological studies have identified associations between increased coffee consumption and decreased recurrence and mortality of colorectal cancer. The association between coffee consumption and survival in patients with advanced or metastatic colorectal cancer is unknown.. ..Among the 1171 patients… Continue reading Association of #Coffee Intake With Survival in Patients With Advanced or Metastatic #Colorectal Cancer
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