Editor’s summaryThe gut #microbiota has long been an aspirational target for clinical delivery of therapeutics. Successful therapy by this route depends on ensuring engraftment of the therapeutic organisms and their clearance after treatment. Whitaker et al. have engineered a strain of Bacteroides vulgatus, which is commonly found in the gut of healthy humans, with two… Continue reading Controlled colonization of the human #gut with a genetically engineered microbial therapeutic
Category: Gastroenterology
#Fecal #metabolite profiling identifies critically #ill patients with increased 30-day #mortality
Critically ill patients admitted to the medical intensive care unit (MICU) have reduced intestinal microbiota diversity and altered microbiome-associated metabolite concentrations. Metabolites produced by the gut microbiota have been associated with survival of patients receiving complex medical treatments and thus might represent a treatable trait to improve clinical outcomes. We prospectively collected fecal specimens, defined… Continue reading #Fecal #metabolite profiling identifies critically #ill patients with increased 30-day #mortality
Social #anxiety disorder-associated gut #microbiota increases #social #fear
Understanding the biological basis of social anxiety disorder (SAD), one of the most disabling of the anxiety disorders, will allow for novel treatment strategies to be developed. Here, we show that gut microbiota may be such a target. Mice that received SAD patient microbiota had a specific heightened sensitivity to social fear without affecting other… Continue reading Social #anxiety disorder-associated gut #microbiota increases #social #fear
Structured #Exercise after Adjuvant Chemotherapy for #Colon #Cancer
Preclinical and observational studies suggest that exercise may improve cancer outcomes. However, definitive level 1 evidence is lacking.MethodsIn this phase 3, randomized trial conducted at 55 centers, we assigned patients with resected colon cancer who had completed adjuvant chemotherapy to participate in a structured exercise program (exercise group) or to receive health-education materials alone (health-education… Continue reading Structured #Exercise after Adjuvant Chemotherapy for #Colon #Cancer
Modifiable factors for #irritable bowel syndrome: evidence from Mendelian randomisation approach
Background The potential modifiable factors influencing irritable bowel syndrome (IBS) have not been thoroughly documented. We aimed to systematically investigate the modifiable factors associated with IBS, while accounting for the impact of unobserved confounders and coexisting disorders.Methods Genetic correlation and Mendelian randomisation (MR) analyses were integrated to identify potential modifiable factors and coexisting disorders linked… Continue reading Modifiable factors for #irritable bowel syndrome: evidence from Mendelian randomisation approach
Phase 3 Trial of #Semaglutide in #Metabolic Dysfunction–Associated Steatohepatitis
Semaglutide, a glucagon-like peptide-1 receptor agonist, is a candidate for the treatment of metabolic dysfunction–associated steatohepatitis (MASH).MethodsIn this ongoing phase 3, multicenter, randomized, double-blind, placebo-controlled trial, we assigned 1197 patients with biopsy-defined MASH and fibrosis stage 2 or 3 in a 2:1 ratio to receive once-weekly subcutaneous semaglutide at a dose of 2.4 mg or… Continue reading Phase 3 Trial of #Semaglutide in #Metabolic Dysfunction–Associated Steatohepatitis
Repeated #COVID-19 #Vaccination as a Poor Prognostic Factor in Pancreatic #Cancer: A Retrospective, Single-Center Cohort Study
AbstractThe COVID-19 vaccine is a significant technological advancement with widespread global use. However, its effect on cancer immunity, particularly with repeated vac-cinations, remains unclear. We aimed to investigate the relationship between repeated vaccinations and pancreatic cancer (PC) prognosis. Additionally, we examined serum IgG4 levels, known to be an immune suppressor and increased with repeated vac-cinations.… Continue reading Repeated #COVID-19 #Vaccination as a Poor Prognostic Factor in Pancreatic #Cancer: A Retrospective, Single-Center Cohort Study
Intestinal #Microbiota Contributes to the Development of #Cardiovascular Inflammation and Vasculitis in Mice
Alterations in the intestinal microbiota contribute to the pathogenesis of various cardiovascular disorders, but how they affect the development of Kawasaki disease (KD) an acute pediatric vasculitis, remains unclear.METHODS:We used the Lactobacillus casei cell wall extract (LCWE) murine model of KD vasculitis to assess the contribution of the intestinal microbiota to the development of vascular… Continue reading Intestinal #Microbiota Contributes to the Development of #Cardiovascular Inflammation and Vasculitis in Mice
Atypical #gut microbial ecosystem from athletes with very high exercise capacity improves insulin sensitivity and muscle glycogen store in mice
Gut bacterial ecosystem is linked to host’s exercise capacity independent of food habits• Despite reduced bacterial diversity, endurance athletes exhibit higher fecal SCFA levels• Gut microbiota from athletes improves insulin sensitivity of transplanted mice• The gut bacterial ecosystem might be driven by access to energy resources left by the hostSummaryAlthough the gut microbiota is known… Continue reading Atypical #gut microbial ecosystem from athletes with very high exercise capacity improves insulin sensitivity and muscle glycogen store in mice
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