Although the BNT162b2 COVID-19 vaccine is known to induce IgG neutralizing antibodies in serum protecting against COVID-19, it has not been studied in detail whether it could generate specific immunity at mucosal sites, which represent the primary route of entry of SARS-CoV-2. MethodsSamples of serum and saliva of 60 BNT162b2-vaccinated healthcare workers were collected at… Continue reading Mucosal immune response in BNT162b2 COVID-19 vaccine recipients
Category: ENT
Intranasal priming induces local lung-resident B cell populations that secrete protective mucosal antiviral IgA
Flu defense via lung-resident IgA+ memory B cellsSecretory IgA antibody is known to be a key effector molecule in establishing effective antiviral immunity in the lungs, but the specific cell types producing this mucosal IgA and their physical locations are unclear. Oh et al. analyzed pulmonary IgA-secreting cells in mice after prior influenza infection or… Continue reading Intranasal priming induces local lung-resident B cell populations that secrete protective mucosal antiviral IgA
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe #COVID-19
SARS-CoV-2 infection can cause severe respiratory COVID-19. However, many individuals present with isolated upper respiratory symptoms, suggesting potential to constrain viral pathology to the nasopharynx. Which cells SARS-CoV-2 primarily targets and how infection influences the respiratory epithelium remains incompletely understood. We performed scRNA-seq on nasopharyngeal swabs from 58 healthy and COVID-19 participants. During COVID-19, we… Continue reading Impaired local intrinsic immunity to SARS-CoV-2 infection in severe #COVID-19
Benzedrex (#propylhexedrine): Drug Safety Communication – FDA Warns that Abuse and Misuse of the Nasal #Decongestant Causes Serious Harm
AUDIENCE: Consumer, Patient, Health Professional, Pharmacy ISSUE: The FDA is warning that the abuse and misuse of the over-the-counter (OTC) nasal decongestant propylhexedrine can lead to serious harm such as heart and mental health problems. Some of these complications, which include fast or abnormal heart rhythm, high blood pressure, and paranoia, can lead to hospitalization,… Continue reading Benzedrex (#propylhexedrine): Drug Safety Communication – FDA Warns that Abuse and Misuse of the Nasal #Decongestant Causes Serious Harm
#Olfactory dysfunction predicts the development of #dementia in older patients with type 2 #diabetes
Olfactory dysfunction is associated with the transition from normal cognition to dementia in persons without type 2 diabetes. This study aimed to investigate whether olfactory dysfunction could be an early marker of future dementia in older patients with type 2 diabetes. Methods This exploratory study included 151 older Japanese outpatients with type 2 diabetes who… Continue reading #Olfactory dysfunction predicts the development of #dementia in older patients with type 2 #diabetes
Use of #proton pump inhibitors to treat persistent #throat symptoms: multicentre, double blind, randomised, placebo controlled trial
To assess the use of proton pump inhibitors (PPIs) to treat persistent throat symptoms.. ..Random blinded allocation (1:1) to either 30 mg lansoprazole twice daily or matched placebo twice daily for 16 weeks. Main outcome measures Primary outcome was symptomatic response at 16 weeks measured using the total reflux symptom index (RSI) score. Secondary outcomes… Continue reading Use of #proton pump inhibitors to treat persistent #throat symptoms: multicentre, double blind, randomised, placebo controlled trial
Lowering the transmission and spread of human coronavirus
The emergence of the severe acute respiratory syndrome coronavirus 2 pandemic has created an unprecedented healthcare, social, and economic disaster. Wearing of masks and social distancing can significantly decrease transmission and spread, however, due to circumstances such as medical or dental intervention and personal choice these practices have not been universally adopted. Additional strategies are… Continue reading Lowering the transmission and spread of human coronavirus
Association of #Hypertension With the Risk and Severity of #Epistaxis
..Among the 35 749 patients in the hypertension cohort (20 579 men [57.6%]; median age, 52 years [interquartile range, 45-62 years]) the incidence rate (IR) of epistaxis was 32.97 per 10 000 persons (95% CI, 30.57-35.51 per 10 000 persons); among the 35 749 individuals in the comparison cohort (20 910 men [58.5%]; median age, 52 years [interquartile range, 45-62 years]),… Continue reading Association of #Hypertension With the Risk and Severity of #Epistaxis
AAO-HNS: #Anosmia, Hyposmia, and #Dysgeusia Symptoms of #Coronavirus Disease
Anecdotal evidence is rapidly accumulating from sites around the world that anosmia and dysgeusia are significant symptoms associated with the COVID-19 pandemic. Anosmia, in particular, has been seen in patients ultimately testing positive for the coronavirus with no other symptoms. We propose that these symptoms be added to the list of screening tools for possible… Continue reading AAO-HNS: #Anosmia, Hyposmia, and #Dysgeusia Symptoms of #Coronavirus Disease
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