More effective treatments are needed for impaired fasting glucose or glucose intolerance, known as prediabetes. Sulforaphane is an isothiocyanate that reduces hepatic gluconeogenesis in individuals with type 2 diabetes and is well tolerated when provided as a broccoli sprout extract (BSE). Here we report a randomized, double-blind, placebo-controlled trial in which drug-naive individuals with prediabetes… Continue reading Effect of #broccoli sprout extract and baseline gut microbiota on fasting blood #glucose in #prediabetes: a randomized, placebo-controlled trial
Category: Diet
Associations Between #Polyphenol Intake, Cardiometabolic Risk Factors and Metabolic Syndrome in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)Author links open overlay panel
BackgroundFruit- and vegetable-rich diets may protect against metabolic syndrome (MetS), partly due to their high polyphenol content.ObjectivesThis study examined the association between dietary polyphenol intake, MetS risk, and cardiometabolic factors in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).MethodsA total of 6387 participants (mean age 49.8 y, 65% female) were included. Food intake was assessed… Continue reading Associations Between #Polyphenol Intake, Cardiometabolic Risk Factors and Metabolic Syndrome in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)Author links open overlay panel
#Sweetener #aspartame aggravates #atherosclerosis through insulin-triggered inflammation
Highlights•Aspartame increases insulin levels through parasympathetic activation•An insulin-dependent mechanism of the aspartame-aggravated atherosclerosis•The CX3CL1-CX3CR1 signaling mediates insulin-induced endothelial inflammation•A CX3CL1-CX3CR1-dependent mechanism of aspartame-exacerbated atherosclerosis SummaryConsumption of artificial sweeteners (ASWs) in various foods and beverages has been linked to an increased risk of cardiovascular diseases (CVDs). However, molecular mechanisms underlying ASW-associated CVD remain unknown. Here, we… Continue reading #Sweetener #aspartame aggravates #atherosclerosis through insulin-triggered inflammation
#Egg Consumption: Trends Over 48 Years, Patterns Across the Lifespan, and Predictors of Intake
Background/Objectives: Eggs are an excellent nutritional source. However, historical associations of dietary cholesterol with serum cholesterol and cardiovascular disease, along with restrictive dietary guidelines may have been barriers to egg consumption. This study examines trends over time, patterns, and predictors of egg consumption in individuals followed for 48 years, and current barriers to usage. Methods:… Continue reading #Egg Consumption: Trends Over 48 Years, Patterns Across the Lifespan, and Predictors of Intake
Long-term #yogurt intake and colorectal #cancer incidence subclassified by Bifidobacterium abundance in tumor
Evidence suggests a tumor-suppressive effect of the intake of yogurt, which typically contains Bifidobacterium. We hypothesized that long-term yogurt intake might be associated with colorectal cancer incidence differentially by tumor subgroups according to the amount of tissue Bifidobacterium. We utilized the prospective cohort incident-tumor biobank method and resources of two prospective cohort studies. Inverse probability… Continue reading Long-term #yogurt intake and colorectal #cancer incidence subclassified by Bifidobacterium abundance in tumor
Suboptimal dietary patterns are associated with accelerated biological #aging in young adulthood: A study with twins
Suboptimal diets increase morbidity and mortality risk. Epigenetic clocks are algorithms that can assess health and lifespan, even at a young age, before clinical manifestations of diseases. We investigated the association between dietary patterns and biological aging in young adult twins. MethodsThe data were drawn from the population-based FinnTwin12 study and consisted of twins aged… Continue reading Suboptimal dietary patterns are associated with accelerated biological #aging in young adulthood: A study with twins
Effects of Vegetable and Fruit #Juicing on Gut and Oral #Microbiome Composition
Background: In recent years, juicing has often been promoted as a convenient way to increase fruit and vegetable intake, with juice-only diets marketed for digestive cleansing and overall health improvement. However, juicing removes most insoluble fiber, which may diminish the health benefits of whole fruits and vegetables. Lower fiber intake can alter the microbiota, affecting… Continue reading Effects of Vegetable and Fruit #Juicing on Gut and Oral #Microbiome Composition
#Sugar-sweetened beverage intake, gut #microbiota, circulating metabolites, and #diabetes risk in Hispanic Community Health Study/Study of Latinos
Highlights• Sugar-sweetened beverage intake was associated with nine gut bacteria abundances• These bacteria were correlated with aromatic and branched-chain amino acid metabolites• These bacteria were correlated with glycerophospholipids• These gut microbial metabolites were associated with diabetes risk SummaryNo population-based studies examined gut microbiota and related metabolites associated with sugar-sweetened beverage (SSB) intake among US adults.… Continue reading #Sugar-sweetened beverage intake, gut #microbiota, circulating metabolites, and #diabetes risk in Hispanic Community Health Study/Study of Latinos
Can #carbonated water support weight loss?
Background Carbonated water has been reported to induce satiety, gastric motility and lower serum glucose concentrations, but the mechanisms remain unclear.Methods This report explores the physiological effects of carbonated water, referencing a study published in 2004 on the mechanisms of hypoglycaemia induced by haemodialysis.Results Upon consumption of carbonated water, carbon dioxide (CO2) is absorbed into… Continue reading Can #carbonated water support weight loss?
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