Importance Light at night causes circadian disruption, which is a known risk factor for adverse cardiovascular outcomes. However, it is not well understood whether personal light exposure patterns predicts and individual’s risk of cardiovascular diseases.Objective To assess whether day and night light exposure predicts incidence of cardiovascular diseases, and whether relationships of light with cardiovascular… Continue reading Personal night #light exposure predicts incidence of #cardiovascular diseases in >88,000 individuals
Category: Cardiology
The relationship between #polyunsaturated #fatty acids and #inflammation: evidence from cohort and Mendelian randomization analyses
Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) are thought to have anti- and pro-inflammatory roles, respectively, and influence the risk of various chronic diseases. However, it is unclear whether these associations are causal.MethodsWe examined the associations of dietary polyunsaturated FAs with biomarkers of systemic inflammation: C-reactive protein (CRP), glycoprotein acetyls (GlycA), and interleukin… Continue reading The relationship between #polyunsaturated #fatty acids and #inflammation: evidence from cohort and Mendelian randomization analyses
Hybrid hydrogel–extracellular matrix scaffolds identify biochemical and mechanical signatures of #cardiac #ageing
Extracellular matrix remodelling of cardiac tissue is a key contributor to age-related cardiovascular disease and dysfunction. Such remodelling is multifaceted including changes to the biochemical composition, architecture and mechanics, clouding our understanding of how and which extracellular matrix properties contribute to a dysfunctional state. Here we describe a decellularized extracellular matrix–synthetic hydrogel hybrid scaffold that… Continue reading Hybrid hydrogel–extracellular matrix scaffolds identify biochemical and mechanical signatures of #cardiac #ageing
Association of #plant -based diets with subclinical #cardiovascular disease in U.S. adults, 1999-2004
BackgroundDietary patterns currently recommended for cardiovascular health often emphasize the consumption of plant foods.MethodsWe included 7,708 participants from the National Health and Nutrition Examination Survey 1999-2004 aged ≥20 years who were not pregnant and did not have a self-reported history of cardiovascular disease. Dietary intake was assessed using a 24-hour dietary recall. All plant-based dietary… Continue reading Association of #plant -based diets with subclinical #cardiovascular disease in U.S. adults, 1999-2004
#Sedentary Behavior and #Cardiac Events and Mortality After Hospitalization for Acute #Coronary Syndrome Symptoms: A Prospective Study
Patients hospitalized with symptoms of acute coronary syndrome remain at high risk for adverse events postdischarge, highlighting a need for modifiable therapeutic targets. The role of sedentary behavior in this risk and the potential benefits of replacing sedentary time with other activities remain unclear. This study examined the association between sedentary behavior and 1-year cardiac… Continue reading #Sedentary Behavior and #Cardiac Events and Mortality After Hospitalization for Acute #Coronary Syndrome Symptoms: A Prospective Study
The overlooked trio: #sleep duration, sampling time and #physical exercise alter levels of olink-assessed blood biomarkers of cardiovascular risk
Biomarker profiling from biofluids such as blood are widely measured in clinical research, using for example Olink proteomics panels. One such research focus area is cardiovascular disease (CVD), for which chronic sleep restriction (SR) is a risk factor. However, it remains unclear whether blood levels of commonly measured CVD biomarkers are sensitive to acute dynamic… Continue reading The overlooked trio: #sleep duration, sampling time and #physical exercise alter levels of olink-assessed blood biomarkers of cardiovascular risk
#Colchicine in acute #coronary syndromes: a systematic review and meta-analysis of randomised controlled trials
Background Acute coronary syndrome (ACS) is a global leading cause of morbidity, with residual inflammation contributing to recurrent events. Colchicine has been proposed as an adjunct therapy, but its efficacy remains uncertain.Methods We performed a systematic review and meta-analysis. PubMed, Embase and Cochrane databases were searched for randomised controlled trials (RCTs) data comparing colchicine versus… Continue reading #Colchicine in acute #coronary syndromes: a systematic review and meta-analysis of randomised controlled trials
Rest #Activity Rhythms and their Association with #Cardiorespiratory Fitness and #Walking Energetics in #Older Adults: Study of Muscle, #Mobility and #Aging
Purpose It is recognized that disruptions in circadian behavior, such as with shift work or jet lag, are associated with diminished health. This known relationship implies that people with stronger indices of circadian behavior will exhibit improved physiology. To address the association between rhythmic activity behavior and physiology we proposed that metrics indicative of ‘more… Continue reading Rest #Activity Rhythms and their Association with #Cardiorespiratory Fitness and #Walking Energetics in #Older Adults: Study of Muscle, #Mobility and #Aging
#Spironolactone vs #Amiloride for Resistant #HypertensionA Randomized Clinical Trial
Importance Amiloride has been proposed as an alternative to spironolactone for treating resistant hypertension. However, no randomized clinical trials have compared the efficacy of spironolactone and amiloride in patients with resistant hypertension.Objective To determine whether amiloride is noninferior to spironolactone in reducing home-measured systolic blood pressure (SBP) in patients with resistant hypertension.Design, Setting, and Participants … Continue reading #Spironolactone vs #Amiloride for Resistant #HypertensionA Randomized Clinical Trial
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