Moderate to vigorous physical activity (MVPA) is strongly associated with risk reductions of noncommunicable diseases and mortality. Cardiovascular health status may influence the benefits of MVPA. We compare the association between MVPA and incident major adverse cardiovascular events (MACE) and mortality between healthy individuals, individuals with elevated levels of cardiovascular risk factors (CVRF), and cardiovascular… Continue reading Dose–response association between moderate to vigorous physical activity and incident morbidity and mortality for individuals with a different cardiovascular health status: A cohort study among 142,493 adults from the Netherlands
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Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunity
Determination of SARS-CoV-2 antibody responses in the context of pre-existing immunity to circulating human coronavirus (HCoV) is critical for understanding protective immunity. Here we perform a multifactorial analysis of SARS-CoV-2 and HCoV antibody responses in pre-pandemic (N = 825) and SARS-CoV-2-infected donors (N = 389) using a custom-designed multiplex ABCORA assay. ABCORA seroprofiling, when combined with computational modeling, enables… Continue reading Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunity
Risk of Hospitalization, severe disease, and mortality due to COVID-19 and PIMS-TS in children with SARS-CoV-2 infection in Germany
Background: Although children and adolescents have a lower burden of SARS-CoV-2-associated disease as compared to adults, assessing absolute risk among children remains difficult due to a high rate of undetected cases. However, without more accurate case numbers, reliable risk analyses are impossible. Methods: We combine data from three sources - a national seroprevalence study (the… Continue reading Risk of Hospitalization, severe disease, and mortality due to COVID-19 and PIMS-TS in children with SARS-CoV-2 infection in Germany
SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN)
Increased understanding of whether individuals who have recovered from COVID-19 are protected from future SARS-CoV-2 infection is an urgent requirement. We aimed to investigate whether antibodies against SARS-CoV-2 were associated with a decreased risk of symptomatic and asymptomatic reinfection. MethodsA large, multicentre, prospective cohort study was done, with participants recruited from publicly funded hospitals in… Continue reading SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN)
Comparing Video-Based, Telehealth-Delivered Exercise and Weight Loss Programs With Online Education on Outcomes of Knee Osteoarthritis
Scalable knee osteoarthritis programs are needed to deliver recommended education, exercise, and weight loss interventions. Objective:To evaluate two 6-month, telehealth-delivered exercise programs, 1 with and 1 without dietary intervention. Design:3-group, parallel randomized (5:5:2) trial. (Australian New Zealand Clinical Trials Registry: ACTRN12618000930280) Setting:Australian private health insurance members. Participants:415 persons with symptomatic knee osteoarthritis and a body… Continue reading Comparing Video-Based, Telehealth-Delivered Exercise and Weight Loss Programs With Online Education on Outcomes of Knee Osteoarthritis
Aspirin use for cancer prevention: A systematic review of public, patient and healthcare provider attitudes and adherence behaviours
Highlights•Most eligible people offered participation in an aspirin trial accepted. •Among participants, most reported high (≥80%) adherence on a day-to-day basis. •No studies examined uptake and adherence in routine care. •Further research is needed to identify the barriers to using aspirin in practice. AbstractWe undertook a systematic review to synthesise the data on attitudes and… Continue reading Aspirin use for cancer prevention: A systematic review of public, patient and healthcare provider attitudes and adherence behaviours
Cytokine signature for predicting new-onset prediabetes after acute pancreatitis: A prospective longitudinal cohort study
Highlights•Interleukin-1β at baseline predicts new-onset prediabetes after acute pancreatitis. •Interferon γ at baseline predicts new-onset prediabetes after pancreatitis. •Changes in adaptive immunity may underlie glucose derangements after pancreatitis. AbstractBackground/purposeAcute inflammation of the pancreas often leads to metabolic sequelae, the most common of which is new-onset prediabetes (and, ultimately, diabetes). However, there is a lack of… Continue reading Cytokine signature for predicting new-onset prediabetes after acute pancreatitis: A prospective longitudinal cohort study
Amateur Boxing and DementiaCognitive Impairment Within the 35-Year Caerphilly Cohort Study
Objective:To examine the long-term effects of amateur boxing in a representative population sample of men. Design:The sample was examined every 5 years for 35 years. Cognition was assessed repeatedly from the third examination. Previous boxing experience and dementia were assessed at the fifth examination, and dementia assessed subsequently through medical records. Setting and Assessment of… Continue reading Amateur Boxing and DementiaCognitive Impairment Within the 35-Year Caerphilly Cohort Study
COVID-19 trends and severity among symptomatic children aged 0 to 17 years in ten EU countries, 3 August 2020 to 3 October 2021
To guide evidence-based prevention of COVID-19 in children, we estimated risks of severe outcomes in 820,404 symptomatic paediatric cases reported by 10 EU Member States between August 2020 and October 2021. Case and hospitalisation rates rose as overall transmission increased but severe outcomes were rare: 9,611 (1.2%) were hospitalised, 640 (0.08%) required intensive care and… Continue reading COVID-19 trends and severity among symptomatic children aged 0 to 17 years in ten EU countries, 3 August 2020 to 3 October 2021
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