The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continues to shape the coronavirus disease 2019 (Covid-19) pandemic. The detection and rapid spread of the SARS-CoV-2 Omicron variant (lineage B.1.1.529) in Botswana and South Africa became a global concern because it contained 15 mutations in the spike protein immunogenic receptor binding domain and… Continue reading Rapid emergence of SARS-CoV-2 Omicron variant is associated with an infection advantage over Delta in vaccinated persons
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The Lancet: COVID-19 pandemic led to stark rise in depressive and anxiety disorders globally in 2020, with women and younger people most affected
First global estimates of impact of the COVID-19 pandemic on mental health in 2020 suggests additional 53 million cases of major depressive disorder and 76 million cases of anxiety disorders were due to the pandemic.Women and younger people were the most affected by major depressive disorder and anxiety disorders in 2020.Countries hit hardest by the… Continue reading The Lancet: COVID-19 pandemic led to stark rise in depressive and anxiety disorders globally in 2020, with women and younger people most affected
Do COVID-19 RNA-based vaccines put at risk of immune-mediated diseases? In reply to “potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases”
To the Editor,I read with great interest the article by Vojdani et al. [1], concerning the hypothesis of a molecular mimicry mechanism between the nucleoprotein/spike protein of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and self-antigens. Viruses are notoriously involved in the pathogenesis of autoimmune diseases [2], and the authors reasonably conclude that such a… Continue reading Do COVID-19 RNA-based vaccines put at risk of immune-mediated diseases? In reply to “potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases”
Transmissibility of SARS-CoV-2 among fully vaccinated individuals
Vaccine effectiveness studies have conclusively demonstrated the benefit of COVID-19 vaccines in reducing individual symptomatic and severe disease, resulting in reduced hospitalisations and intensive care unit admissions.1 However, the impact of vaccination on transmissibility of SARS-CoV-2 needs to be elucidated. A prospective cohort study in the UK by Anika Singanayagam and colleagues2 regarding community transmission… Continue reading Transmissibility of SARS-CoV-2 among fully vaccinated individuals
A Systematic Review of the Protective Effect of Prior SARS-CoV-2 Infection on Repeat Infection
We systematically reviewed studies to estimate the risk of SARS-CoV-2 reinfection among those previously infected with SARS-CoV-2. For this systematic review, we searched scientific publications on PubMed and MedRxiv, a pre-print server, through August 18, 2021. Eligible studies were retrieved on August 18, 2021. The following search term was used on PubMed: (((“Cohort Studies”[Majr]) AND… Continue reading A Systematic Review of the Protective Effect of Prior SARS-CoV-2 Infection on Repeat Infection
Clarifying the evidence on SARS-CoV-2 antigen rapid tests in public health responses to COVID-19
The use of rapid lateral flow antigen testing (LFT) for SARS-CoV-2 has been questioned1, 2, 3 with uncorroborated4 reports of poor LFT sensitivity. The debate surrounding the use of the Innova Lateral Flow SARS-CoV-2 Antigen Test in the UK risks confusing policy makers internationally and potentially stalling deployment of LFTs in other countries.5 As scientists… Continue reading Clarifying the evidence on SARS-CoV-2 antigen rapid tests in public health responses to COVID-19
Diffusion-Magnetic Resonance Imaging predicts decline of kidney function in chronic kidney disease and in patients with a kidney allograft
Kidney cortical interstitial fibrosis is highly predictive of kidney prognosis and is currently assessed by evaluation of a biopsy. Diffusion-weighted magnetic resonance imaging is a promising non-invasive tool to evaluate kidney fibrosis. We recently adapted diffusion-weighted imaging sequence for discrimination between the kidney cortex and medulla and found that the cortico-medullary difference in apparent diffusion… Continue reading Diffusion-Magnetic Resonance Imaging predicts decline of kidney function in chronic kidney disease and in patients with a kidney allograft
Atypical Kawasaki Disease after COVID-19 Vaccination: A NewForm of Adverse Event Following Immunization
Abstract: Kawasaki disease (KD) is a medium-vessel vasculitis that is typically presented duringchildhood; fewer than 100 cases of KD have been reported worldwide in adult patients who metthe criteria according to the American College of Rheumatology. This study presents the case ofan 18-year-old patient with no previous history of any disease, who presented atypical KD… Continue reading Atypical Kawasaki Disease after COVID-19 Vaccination: A NewForm of Adverse Event Following Immunization
Triple Vaccinated put the most pressure on the NHS by far over the past 4 weeks according to UKHSA with 74% of Covid-19 hospitalisations recorded among the Vaccinated
The latest data available from the UK Health Security Agency confirms that the triple vaccinated population accounted for the majority of all Covid-19 hospitalisations between 20th Dec 21 and 16th Jan 22, with the double vaccinated population not far behind. The UK Health Security Agency (UKHSA) publish a weekly Covid-19 Vaccine Surveillance Report containing data… Continue reading Triple Vaccinated put the most pressure on the NHS by far over the past 4 weeks according to UKHSA with 74% of Covid-19 hospitalisations recorded among the Vaccinated
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