Homocysteine (HCY) has been implicated in cardiovascular disease through adverse effects on vascular endothelium, oxidative stress, and thrombogenic pathways. Saudi Arabia has a young population and an increasing burden of cardiovascular disease, yet regional data on HCY and B-vitamin profiles in premature acute coronary syndrome (ACS) remain limited. This single-center cross-sectional exploratory study evaluated serum… Continue reading Role of homocysteine, vitamins B12, B6, B1, and folate in Saudi patients with premature acute coronary syndrome
Tag: vitamins
Exploring the link between water-soluble vitamins and aging-associated immune system status
Background: #Aging is associated with numerous physiological changes that contribute to immunosenescence and inflammaging, resulting in a decline in immune defense and an increased susceptibility to infections. Older adults are at risk of inadequate dietary intake and suboptimal supply of micronutrients, including water-soluble #vitamins, even those generally considered sufficient in the overall population. These deficiencies… Continue reading Exploring the link between water-soluble vitamins and aging-associated immune system status
Vitamin #B6 predicts poor outcomes in geographically distinct populations with primary sclerosing cholangitis
Background & aims: Primary sclerosing cholangitis (#PSC ) has a variable disease course, complicating patient counseling and timing of liver transplantation. Vitamin B6 deficiency predicts reduced liver transplantation-free survival in Scandinavian PSC cohorts. Here, we aimed to validate this observation in U.S. and German PSC cohorts and expanded our analyses to include hepatic decompensation as… Continue reading Vitamin #B6 predicts poor outcomes in geographically distinct populations with primary sclerosing cholangitis
Vitamin #D3 and marine ω-3 fatty acids supplementation and leukocyte #telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial
Limited studies suggest that vitamin D or omega 3 fatty acids (n–3 FAs) supplementation may be beneficial for telomere maintenance; however, evidence from large randomized clinical trials is lacking. We hypothesized that vitamin D or n–3 FAs supplementation reduce leukocyte telomere length (LTL) attrition over time by leveraging the VITamin D and OmegA-3 TriaL (VITAL)… Continue reading Vitamin #D3 and marine ω-3 fatty acids supplementation and leukocyte #telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial
Subcellular #NAD+ pools are interconnected and buffered by mitochondrial NAD+
The coenzyme NAD+ is consumed by signalling enzymes, including poly-ADP-ribosyltransferases (PARPs) and sirtuins. Ageing is associated with a decrease in cellular NAD+ levels, but how cells cope with persistently decreased NAD+ concentrations is unclear. Here, we show that subcellular NAD+ pools are interconnected, with mitochondria acting as a rheostat to maintain NAD+ levels upon excessive… Continue reading Subcellular #NAD+ pools are interconnected and buffered by mitochondrial NAD+
Effect of #Ergocalciferol on β-Cell Function in New-Onset Type 1 #Diabetes A Secondary Analysis of a Randomized Clinical Trial
IntroductionApproximately 30% to 50% residual β-cell function may remain at the time of type 1 diabetes (T1D) diagnosis, and this may persist for months or years.1,2 A prolonged partial remission (PR) phase of T1D leads to improved glycemic control and decreased long-term complications.1 We previously reported1 that ergocalciferol significantly decreased circulating tumor necrosis factor (TNF)-α and temporal trends… Continue reading Effect of #Ergocalciferol on β-Cell Function in New-Onset Type 1 #Diabetes A Secondary Analysis of a Randomized Clinical Trial
Vitamin #E intake is inversely associated with #NAFLD measured by liver ultrasound transient elastography
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases, whose severe form is associated with oxidative stress. Vitamin E as an antioxidant has a protective potential in NAFLD. Whether dietary intake of vitamin E, supplementary vitamin E use, and total vitamin E have a preventive effect on NAFLD requires investigation.… Continue reading Vitamin #E intake is inversely associated with #NAFLD measured by liver ultrasound transient elastography
Vitamin #D and Marine n-3 #Fatty Acids for #Autoimmune Disease Prevention: Outcomes at Two Years after VITAL Trial Completion
ObjectiveIn the 5.3 year randomized, 2 x 2 factorial, double-blind, placebo-controlled VITamin D and OmegA-3 TriaL (VITAL), vitamin D supplementationreduced autoimmune disease (AD) incidence (hazard ratio [HR] 0.78, 95% confidence interval 0.61-0.99). Omega-3(n-3) fatty acid supplementation showed a statistically non-significant reduction (HR 0.85, 0.67-1.08). We aimed to confirm further AD cases arising during and after randomization and… Continue reading Vitamin #D and Marine n-3 #Fatty Acids for #Autoimmune Disease Prevention: Outcomes at Two Years after VITAL Trial Completion
Post-diagnostic #multivitamin supplement use and #colorectal cancer survival: A prospective cohort study
AbstractBackgroundUse of multivitamin supplements has been associated with lower incidence of colorectal cancer (CRC). However, its influence on CRC survival remains unknown.MethodsAmong 2424 patients with stage I–III CRC who provided detailed information about multivitamin supplements in the Nurses’ Health Study and Health Professionals Follow-up Study, the authors calculated multivariable hazard ratios (HRs) of multivitamin supplements… Continue reading Post-diagnostic #multivitamin supplement use and #colorectal cancer survival: A prospective cohort study
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