Highlights•n-3 and n-6 PUFAs preferentially accumulate in lipid droplets of acidic cancer cells •Excess LC-PUFAs undergo peroxidation and induce ferroptosis in acidic cancer cells •DGAT inhibitors prevent the formation of lipid droplets and promote ferroptosis •DGATi enhance the tumor growth inhibitory effects of dietary n-3 LC-PUFAs in mice SummaryTumor acidosis promotes disease progression through a… Continue reading Peroxidation of n-3 and n-6 polyunsaturated #fatty acids in the acidic #tumor environment leads to ferroptosis-mediated anticancer effects
Tag: omega-3
Effect of Marine #Omega-3 Fatty Acid and Vitamin #D Supplementation on Incident Atrial #Fibrillation
Atrial fibrillation (AF) is the most common heart rhythm disturbance, continues to increase in incidence, and results in significant morbidity and mortality. The marine omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and vitamin D have been reported to have both benefits and risks with respect to incident AF, but large-scale, long-term randomized… Continue reading Effect of Marine #Omega-3 Fatty Acid and Vitamin #D Supplementation on Incident Atrial #Fibrillation
Effect of Vitamin #D and ω-3 #Fatty Acid Supplementation on Risk of Age-Related #Macular Degeneration An Ancillary Study of the VITAL Randomized Clinical Trial
Observational studies suggest that higher intake or blood levels of vitamin D and marine ω-3 fatty acids may be associated with lower risks of age-related macular degeneration (AMD). However, evidence from randomized trials is limited.. ..In total, 25 871 participants with a mean (SD) age of 67.1 (7.0) years were included in the trial. Of them,… Continue reading Effect of Vitamin #D and ω-3 #Fatty Acid Supplementation on Risk of Age-Related #Macular Degeneration An Ancillary Study of the VITAL Randomized Clinical Trial
Effects of One Year of Vitamin #D and Marine #Omega-3 Fatty Acid Supplementation on Biomarkers of Systemic Inflammation in Older US Adults
..(VITAL) tested vitamin D (2000 IU/day) and/or n-3 FA (1 g/day) supplementation in a 2 × 2 factorial design among women ≥55 and men ≥50 years of age. Baseline characteristics were well balanced. In the active arms, 25-OH vitamin D rose 39% and n-3 FA rose 55% vs minimal change in placebo arms. Neither supplement… Continue reading Effects of One Year of Vitamin #D and Marine #Omega-3 Fatty Acid Supplementation on Biomarkers of Systemic Inflammation in Older US Adults
Marine #Omega‐3 Supplementation and #Cardiovascular Disease: An Updated Meta‐Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants
In the analysis excluding REDUCE‐IT (Reduction of Cardiovascular Events with Icosapent Ethyl‐Intervention Trial), marine omega‐3 supplementation was associated with significantly lower risk of myocardial infarction (rate ratio [RR] [95% CI]: 0.92 [0.86, 0.99]; P=0.020), CHD death (RR [95% CI]: 0.92 [0.86, 0.98]; P=0.014), total CHD (RR [95% CI]: 0.95 [0.91, 0.99]; P=0.008), CVD death (RR… Continue reading Marine #Omega‐3 Supplementation and #Cardiovascular Disease: An Updated Meta‐Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants
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