Tag: longevity

#Dietary restriction impacts health and #lifespan of genetically diverse mice

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Caloric restriction extends healthy lifespan in multiple species1. Intermittent fasting, an alternative form of dietary restriction, is potentially more sustainable in humans, but its effectiveness remains largely unexplored2,3,4,5,6,7,8. Identifying the most efficacious forms of dietary restriction is key for developing interventions to improve human health and longevity9. Here we performed an extensive assessment of graded… Continue reading #Dietary restriction impacts health and #lifespan of genetically diverse mice

Blood biomarker profiles and exceptional #longevity: comparison of centenarians and non-centenarians in a 35-year follow-up of the Swedish AMORIS cohort

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Comparing biomarker profiles measured at similar ages, but earlier in life, among exceptionally long-lived individuals and their shorter-lived peers can improve our understanding of aging processes. This study aimed to (i) describe and compare biomarker profiles at similar ages between 64 and 99 among individuals eventually becoming centenarians and their shorter-lived peers, (ii) investigate the association… Continue reading Blood biomarker profiles and exceptional #longevity: comparison of centenarians and non-centenarians in a 35-year follow-up of the Swedish AMORIS cohort

Association of Later-Life #Weight Changes With #Survival to Ages 90, 95, and 100: The Women’s Health Initiative

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BackgroundAssociations of weight changes and intentionality of weight loss with longevity are not well described.MethodsUsing longitudinal data from the Women’s Health Initiative (N = 54 437; 61–81 years), we examined associations of weight changes and intentionality of weight loss with survival to ages 90, 95, and 100. Weight was measured at baseline, year 3, and year 10,… Continue reading Association of Later-Life #Weight Changes With #Survival to Ages 90, 95, and 100: The Women’s Health Initiative

Nutrition, longevity and disease: From molecular mechanisms to interventions

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Diet as a whole, encompassing food composition, calorie intake, and the length and frequency of fasting periods, affects the time span in which health and functional capacity are maintained. Here, we analyze aging and nutrition studies in simple organisms, rodents, monkeys, and humans to link longevity to conserved growth and metabolic pathways and outline their… Continue reading Nutrition, longevity and disease: From molecular mechanisms to interventions

Decreasing human body #temperature in the United States since the industrial revolution

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In 1851, the German In 1851, the German physician Carl Reinhold August Wunderlich obtained millions of axillary temperatures from 25,000 patients in Leipzig, thereby establishing the standard for normal human body temperature of 37°C or 98.6 °F (range: 36.2–37.5°C [97.2- 99.5 °F]) (Mackowiak, 1997; Wunderlich and Sequin, 1871). A compilation of 27 modern studies, however… Continue reading Decreasing human body #temperature in the United States since the industrial revolution