The Mortality Index for Alcohol-Associated Hepatitis: A Novel Prognostic Score

ObjectiveTo develop a new scoring system that more accurately predicts 30-day mortality in patients with alcohol-associated hepatitis (AH). MethodsA cohort of consecutive adults diagnosed with AH at a single academic center from January 1, 1998, to December 31, 2018, was identified for model derivation. Multivariate logistic regression was used to create a new scoring system …

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Hypoglycemia associated with direct-acting anti-hepatitis C virus drugs: An epidemiologic surveillance study of the FDA adverse event reporting system (FAERS)

Hypoglycemia induced by direct-acting antiviral agents (DAAs) for chronic hepatitis C virus (HCV) infection is a rare but potentially life-threatening adverse reaction, which led to warnings by competent authorities. We therefore aimed to examine the hypoglycemic safety signal for DAAs. MethodsReports to the US Food and Drug Administration Adverse Event Reporting System (FAERS) from 1 …

Continue reading Hypoglycemia associated with direct-acting anti-hepatitis C virus drugs: An epidemiologic surveillance study of the FDA adverse event reporting system (FAERS)

Liver expression of IL-22, IL-22R1 and IL-22BP in patients with chronic hepatitis C with different fibrosis stages

Highlights•Liver biopsies at stage F1 to F3 expressed more IL-22 than F0 or F4. •The number of cells expressing IL-22R1 decreased as fibrosis increased. •There was an increase in Il-22BP staining in more advanced stages of fibrosis. •IL-22 pathway may be involved in the pathophysiology of liver fibrosis. AbstractLiver fibrosis is the result of an …

Continue reading Liver expression of IL-22, IL-22R1 and IL-22BP in patients with chronic hepatitis C with different fibrosis stages

Hepatitis #C Virus Reactivation Following #COVID-19 Vaccination – A Case Report

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection impacted morbidity and mortality during the pandemic of 2020–2021. A number of anti-COVID-19 vaccines have been developed with an unprecedented speed. While these vaccines have good efficacy and are safe, the experience with their use is limited and hence the knowledge of rare side effects. Identifying rare …

Continue reading Hepatitis #C Virus Reactivation Following #COVID-19 Vaccination – A Case Report

The changing characteristics of patients infected with chronic hepatitis #C virus from 2014 to 2019: Real-world data from the German #Hepatitis C-Registry (DHC-R)

The number of patients diagnosed with hepatitis C virus (HCV) is markedly higher than the number initiating treatment indicating gaps in the care cascade, likely centered around reaching at-risk populations. Understanding changing characteristics of patients with HCV allows for targeted programs that increase linkage to care. We investigated changes in demographic and clinical characteristics of …

Continue reading The changing characteristics of patients infected with chronic hepatitis #C virus from 2014 to 2019: Real-world data from the German #Hepatitis C-Registry (DHC-R)