Dietary vitamin #K intake associates with reduced all-cause #mortality in non-alcoholic #fatty #liver disease patients

This study aimed to investigate the association between dietary vitamin K intake and all-cause mortality in individuals with non-alcoholic fatty liver disease (NAFLD). We analyzed data from 7857 NAFLD participants in the National Health and Nutrition Examination Survey (NHANES 2005–2018) linked to mortality outcomes from the National Death Index (NDI). Dietary vitamin K intake was… Continue reading Dietary vitamin #K intake associates with reduced all-cause #mortality in non-alcoholic #fatty #liver disease patients

Screening for advanced #liver fibrosis due to metabolic dysfunction-associated #steatotic liver disease alongside #retina scanning in people with type 2 diabetes: a cross-sectional study

BackgroundInternational guidelines suggest screening for advanced fibrosis due to metabolic dysfunction-associated steatotic liver disease in people with type 2 diabetes, but how to implement these guidelines in clinical care remains unclear. We hypothesise that examination with VCTE could be implemented simultaneously with retina scanning with a high acceptance rate in people with type 2 diabetes.… Continue reading Screening for advanced #liver fibrosis due to metabolic dysfunction-associated #steatotic liver disease alongside #retina scanning in people with type 2 diabetes: a cross-sectional study

Associations of #sex-related and #thyroid-related #hormones with risk of metabolic dysfunction-associated fatty #liver disease in T2DM patients

BackgroundWe aimed to examine sex-specific associations between sex- and thyroid-related hormones and the risk of metabolic dysfunction-associated fatty liver disease (MAFLD) in patients with type 2 diabetes mellitus (T2DM)MethodsCross-sectional analyses of baseline information from an ongoing cohort of 432 T2DM patients (185 women and 247 men) in Xiamen, China were conducted. Plasma sex-related hormones, including… Continue reading Associations of #sex-related and #thyroid-related #hormones with risk of metabolic dysfunction-associated fatty #liver disease in T2DM patients

Multi-omic network analysis identified #betacellulin as a novel target of #omega-3 fatty acid attenuation of western diet-induced nonalcoholic #steatohepatitis

Clinical and preclinical studies established that supplementing diets with ω3 polyunsaturated fatty acids (PUFA) can reduce hepatic dysfunction in nonalcoholic steatohepatitis (NASH) but molecular underpinnings of this action were elusive. Herein, we used multi-omic network analysis that unveiled critical molecular pathways involved in ω3 PUFA effects in a preclinical mouse model of western diet induced… Continue reading Multi-omic network analysis identified #betacellulin as a novel target of #omega-3 fatty acid attenuation of western diet-induced nonalcoholic #steatohepatitis

The Potential Role of Vitamin #E in Managing Non-Alcoholic Fatty #Liver Disease: Insights from Japan’s Aichi Medical University Study

Non-Alcoholic Fatty Liver Disease (NAFLD) has emerged as a significant public health concern, affecting millions of individuals worldwide. Characterized by the accumulation of fat in the liver without excessive alcohol consumption, NAFLD can progress to more severe conditions, such as non-alcoholic steatohepatitis (NASH) and cirrhosis. While lifestyle modifications remain a cornerstone in managing NAFLD, recent… Continue reading The Potential Role of Vitamin #E in Managing Non-Alcoholic Fatty #Liver Disease: Insights from Japan’s Aichi Medical University Study

Dietary Patterns, Foods, and #Nutrients to Ameliorate Non-Alcoholic #Fatty Liver Disease: A Scoping Review

Background: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease without pharmacological treatment yet. There is also a lack of specific dietary recommendations and strategies to treat the negative health impacts derived from NAFLD. Objective: This scoping review aimed to compile dietary patterns, foods, and nutrients to ameliorate NAFLD. Methods:… Continue reading Dietary Patterns, Foods, and #Nutrients to Ameliorate Non-Alcoholic #Fatty Liver Disease: A Scoping Review

Association of nonalcoholic fatty #liver disease with #colorectal adenomatous #polyps and non-adenomatous polyps: a cross-sectional study

Aim This study aimed to investigate the association between non-alcoholic fatty liver disease (NAFLD) and both colorectal adenomatous polyps and non-adenomatous polyps, in order to provide evidence for the prevention of colorectal cancer (CRC) in patients with NAFLD.Methods A retrospective, cross-sectional study was conducted at the First People’s Hospital of Kunshan, Jiangsu, China. The study included 3028 adults who… Continue reading Association of nonalcoholic fatty #liver disease with #colorectal adenomatous #polyps and non-adenomatous polyps: a cross-sectional study

Resistant #starch decreases intrahepatic #triglycerides in patients with #NAFLD via gut microbiome alterations

Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic dysfunction for which effective interventions are lacking. To investigate the effects of resistant starch (RS) as a microbiota-directed dietary supplement for NAFLD treatment, we coupled a 4-month randomized placebo-controlled clinical trial in individuals with NAFLD (ChiCTR-IOR-15007519) with metagenomics and metabolomics analysis. Relative to the… Continue reading Resistant #starch decreases intrahepatic #triglycerides in patients with #NAFLD via gut microbiome alterations

High #parathyroid hormone level as a marker of non-alcoholic #fatty #liver disease and non-alcoholic steatohepatitis: A systematic review and meta-analysis

Highlights•Studies have shown that high PTH was associated with NAFLD/NASH, although the results from existing studies are inconsistent.•Using systematic review, 10 and 4 studies reported the association of PTH with NAFLD and NASH, respectively.•The meta-analysis suggested that high PTH can be a marker of NAFLD.•The meta-analysis also revealed that high PTH tended to be associated… Continue reading High #parathyroid hormone level as a marker of non-alcoholic #fatty #liver disease and non-alcoholic steatohepatitis: A systematic review and meta-analysis