The inhabitants of our intestines, collectively called the gut microbiome, comprise fungi, viruses, and bacterial strains. These microorganisms are involved in the fermentation of dietary compounds and the regulation of our adaptive and innate immune systems. Less known is the reciprocal interaction between the gut microbiota and type 2 diabetes mellitus (T2DM), as well as… Continue reading The central role of the gut #microbiota in the pathophysiology and management of type 2 #diabetes
Tag: Diabetes
Energy Intake and Dietary Glycemic Load in Late Morning and Risk of Type 2 #Diabetes: The Hispanic Community #Health Study/Study of #Latinos, a Multicenter Prospective Cohort Study
To evaluate the association between meal timing and type 2 diabetes risk in U.S. Hispanic/Latino adults.RESEARCH DESIGN AND METHODSThe Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, community-based, prospective cohort study. This study included 8,868 HCHS/SOL adults without diabetes at baseline (2008–2011) and attending the visit 2 examination (2014–2017). Energy intake and glycemic… Continue reading Energy Intake and Dietary Glycemic Load in Late Morning and Risk of Type 2 #Diabetes: The Hispanic Community #Health Study/Study of #Latinos, a Multicenter Prospective Cohort Study
Glycated Hemoglobin A1c Time in Range and #Dementia in Older Adults With #Diabetes
Key PointsQuestion In older individuals with diabetes, is maintaining stability of glycated hemoglobin A1c levels (HbA1c) in individualized target ranges over time associated with lower risk of Alzheimer disease and related dementias (ADRD)?Findings In this cohort study of 374 021 older veterans with diabetes, greater HbA1c stability, as measured by HbA1c time in range, was associated with a lower risk of… Continue reading Glycated Hemoglobin A1c Time in Range and #Dementia in Older Adults With #Diabetes
#Dried fruit intake and lower risk of type 2 #diabetes: a two-sample mendelian randomization study
BackgroundPrevious studies have shown controversy about whether dried fruit intake is associated with type 2 diabetes. This study aimed to examine the potential causal effect of dried fruit intake on type 2 diabetes by conducting a two-sample Mendelian randomization study.MethodsWe used genome-wide association study (GWAS) summary statistics for MR analysis to explore the causal association… Continue reading #Dried fruit intake and lower risk of type 2 #diabetes: a two-sample mendelian randomization study
Metabolic effects of very-low calorie #diet, #Semaglutide, or combination of the two, in individuals with type 2 #diabetes mellitus
Background & aimsVery-low calorie diets (VLCD) and the glucagon-like peptide-1 receptor agonist (GLP1RA) Semaglutide induce significant weight loss and improve glycaemic control in individuals with type 2 diabetes (T2D). This pilot study was conducted to explore the comparative short-term effects of these interventions individually, and in combination, on weight, body composition and metabolic outcomes.MethodsThirty individuals… Continue reading Metabolic effects of very-low calorie #diet, #Semaglutide, or combination of the two, in individuals with type 2 #diabetes mellitus
Strain-specific gut #microbial signatures in type 2 #diabetes identified in a cross-cohort analysis of 8,117 metagenomes
The association of gut microbial features with type 2 diabetes (T2D) has been inconsistent due in part to the complexity of this disease and variation in study design. Even in cases in which individual microbial species have been associated with T2D, mechanisms have been unable to be attributed to these associations based on specific microbial… Continue reading Strain-specific gut #microbial signatures in type 2 #diabetes identified in a cross-cohort analysis of 8,117 metagenomes
(OR02-02-24) Identification of a Novel Multi-target Bioactive Compound With Anti-#obesity and Anti-#diabetic Activities
Objectives: Insulin resistance and progressive decline in functional β-cell mass are two key factors for developing type 2 diabetes (T2D), which is largely driven by overweight and obesity, a significant obstacle for effective metabolic control in many patients with T2D. We recently found that elenolic acid (EA), a small molecule derived from olive can directly stimulate intestinal… Continue reading (OR02-02-24) Identification of a Novel Multi-target Bioactive Compound With Anti-#obesity and Anti-#diabetic Activities
#Glucagon-like peptide-1 receptor agonists and #stroke: A systematic review and meta-analysis of #cardiovascular outcome trials
Background:In patients surviving stroke, approximately 15% and 60% exhibit concurrent diabetes mellitus and overweight/obesity, respectively, necessitating heightened secondary prevention efforts. Despite glucagon-like peptide-1 receptor agonists (GLP-1 RAs) demonstrating improved outcomes for those with diabetes mellitus or obesity, their underutilization persists among eligible individuals. This systematic review and meta-analysis investigated the impact of GLP-1 RAs on… Continue reading #Glucagon-like peptide-1 receptor agonists and #stroke: A systematic review and meta-analysis of #cardiovascular outcome trials
Higher blood concentrations of #testosterone are associated with reduced risk of developing type 2 #diabetes in men under 65
Testosterone appears protective against developing type 2 diabetes in men who are overweight or obese and under age 65, but not in men over that age, according to a study presented Saturday at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass.“A low blood testosterone concentration is an independent risk factor for developing type… Continue reading Higher blood concentrations of #testosterone are associated with reduced risk of developing type 2 #diabetes in men under 65
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