Importance Vision impairment is a potentially modifiable risk factor for dementia. Although few prior studies have estimated the contribution of vision impairments to dementia, none have reported on multiple objectively measured vision impairments (eg, distance and near visual acuity and contrast sensitivity) in a nationally representative sample of older adults.Objective To quantify population attributable fractions of dementia… Continue reading #Vision Impairment and the Population Attributable Fraction of #Dementia in Older Adults
Tag: Dementia
#Vision Impairment and the Population Attributable Fraction of #Dementia in Older #Adults
Importance Vision impairment is a potentially modifiable risk factor for dementia. Although few prior studies have estimated the contribution of vision impairments to dementia, none have reported on multiple objectively measured vision impairments (eg, distance and near visual acuity and contrast sensitivity) in a nationally representative sample of older adults.Objective To quantify population attributable fractions of dementia… Continue reading #Vision Impairment and the Population Attributable Fraction of #Dementia in Older #Adults
Acute #Kidney Injury and Its Association With #Dementia and Specific Dementia Types
Background and ObjectivesPreclinical studies suggest that acute kidney injury (AKI) results in biochemical and pathologic changes in the brain. We aimed to explore the association between experiencing AKI and subsequent risks of developing dementia.MethodsWe conducted a study involving individuals aged 65 years and older in Stockholm from 2006 to 2019, who were free from dementia… Continue reading Acute #Kidney Injury and Its Association With #Dementia and Specific Dementia Types
The effect of #anxiety on all-cause #dementia: A longitudinal analysis from the Hunter Community Study
BackgroundAnxiety is common, however, the effect of chronicity of anxiety on dementia has not been explored. This study aims to assess the longitudinal relationship between chronic versus resolved versus new onset anxiety, and all-cause dementia risk.MethodsA total of 2132 participants with mean age 76 years from the Hunter Community Study were recruited. Anxiety was measured using… Continue reading The effect of #anxiety on all-cause #dementia: A longitudinal analysis from the Hunter Community Study
Glycated Hemoglobin A1c Time in Range and #Dementia in Older Adults With #Diabetes
Key PointsQuestion In older individuals with diabetes, is maintaining stability of glycated hemoglobin A1c levels (HbA1c) in individualized target ranges over time associated with lower risk of Alzheimer disease and related dementias (ADRD)?Findings In this cohort study of 374 021 older veterans with diabetes, greater HbA1c stability, as measured by HbA1c time in range, was associated with a lower risk of… Continue reading Glycated Hemoglobin A1c Time in Range and #Dementia in Older Adults With #Diabetes
The predictive validity of a #Brain Care Score for late-life #depression and a composite outcome of #dementia, #stroke, and late-life #depression: data from the UK Biobank cohort
Introduction: The 21-point Brain Care Score (BCS) is a novel tool designed to motivate individuals and care providers to take action to reduce the risk of stroke and dementia by encouraging lifestyle changes. Given that late-life depression is increasingly recognized to share risk factors with stroke and dementia, and is an important clinical endpoint for brain… Continue reading The predictive validity of a #Brain Care Score for late-life #depression and a composite outcome of #dementia, #stroke, and late-life #depression: data from the UK Biobank cohort
#AI-based differential diagnosis of #dementia etiologies on multimodal data
Differential diagnosis of dementia remains a challenge in neurology due to symptom overlap across etiologies, yet it is crucial for formulating early, personalized management strategies. Here, we present an artificial intelligence (AI) model that harnesses a broad array of data, including demographics, individual and family medical history, medication use, neuropsychological assessments, functional evaluations and multimodal… Continue reading #AI-based differential diagnosis of #dementia etiologies on multimodal data
Association of Terazosin, Doxazosin, or Alfuzosin Use and Risk of #Dementia With #Lewy Bodies in Men
Background and ObjectivesTerazosin, doxazosin, and alfuzosin (Tz/Dz/Az) are α-1 adrenergic receptor antagonists that also bind to and activate a key adenosine triphosphate (ATP)–producing enzyme in glycolysis. It is hypothesized that the increase in energy availability in the brain may slow or prevent neurodegeneration, potentially by reducing the accumulation of alpha-synuclein. Recent work has suggested a… Continue reading Association of Terazosin, Doxazosin, or Alfuzosin Use and Risk of #Dementia With #Lewy Bodies in Men
Changes in prevalence and incidence of #dementia and risk factors for dementia: an analysis from cohort studies
BackgroundSome cohort studies have reported a decline in dementia prevalence and incidence over time, although these findings have not been consistent across studies. We reviewed evidence on changes in dementia prevalence and incidence over time using published population-based cohort studies that had used consistent methods with each wave and aimed to quantify associated changes in… Continue reading Changes in prevalence and incidence of #dementia and risk factors for dementia: an analysis from cohort studies
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