Height has been associated with many clinical traits but whether such associations are causal versus secondary to confounding remains unclear in many cases. To systematically examine this question, we performed a Mendelian Randomization-Phenome-wide association study (MR-PheWAS) using clinical and genetic data from a national healthcare system biobank. Methods and findingsAnalyses were performed using data from… Continue reading A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program
Tag: CVD
Cardiovascular and Cerebrovascular Disease Mortality in Asian American Subgroups
Background:Asian American individuals comprise the fastest-growing race and ethnic group in the United States. Certain subgroups may be at disproportionately high cardiovascular risk. This analysis aimed to identify cardiovascular and cerebrovascular disease mortality trends in Asian American subgroups. Methods:Age-standardized mortality rates (ASMR), average annual percent change of ASMR calculated by regression, and proportional mortality ratios… Continue reading Cardiovascular and Cerebrovascular Disease Mortality in Asian American Subgroups
Supper Timing and Cardiovascular Mortality: The Japan Collaborative Cohort Study
Evidence on the role of supper timing in the development of cardiovascular disease (CVD) is limited. In this study, we examined the associations between supper timing and risks of mortality from stroke, coronary heart disease (CHD), and total CVD. A total of 28,625 males and 43,213 females, aged 40 to 79 years, free from CVD… Continue reading Supper Timing and Cardiovascular Mortality: The Japan Collaborative Cohort Study
Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation
Epidemiological studies reveal that marijuana increases the risk of cardiovascular disease (CVD); however, little is known about the mechanism. Δ9-tetrahydrocannabinol (Δ9-THC), the psychoactive component of marijuana, binds to cannabinoid receptor 1 (CB1/CNR1) in the vasculature and is implicated in CVD. A UK Biobank analysis found that cannabis was an risk factor for CVD. We found… Continue reading Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation
A Three-Case Series of Thrombotic Deaths in Patients over 50 with Comorbidities Temporally after modRNA COVID-19 Vaccination
Coronavirus disease 2019 (COVID-19) is the most dramatic pandemic of the new millennium; to counteract it, specific vaccines have been launched in record time under emergency use authorization or conditional marketing authorization by virtue of a favorable risk/benefit balance. Among the various technological platforms, there is that exploiting a nucleoside-modified messenger RNA (modRNA), such as… Continue reading A Three-Case Series of Thrombotic Deaths in Patients over 50 with Comorbidities Temporally after modRNA COVID-19 Vaccination
Hourly Air Pollutants and Acute Coronary Syndrome Onset In 1.29 Million Patients
Short-term exposure to ambient air pollution has been linked with daily hospitalization and mortality of acute coronary syndrome (ACS); however, the associations of sub-daily (hourly) levels of criteria air pollutants with the onset of ACS and its subtypes have rarely been evaluated. Methods: We conducted a time-stratified case-crossover study among 1,292,880 ACS patients from 2,239… Continue reading Hourly Air Pollutants and Acute Coronary Syndrome Onset In 1.29 Million Patients
Increased emergency cardiovascular events among under-40 population in Israel during vaccine rollout and third COVID-19 wave
Cardiovascular adverse conditions are caused by coronavirus disease 2019 (COVID-19) infections and reported as side-effects of the COVID-19 vaccines. Enriching current vaccine safety surveillance systems with additional data sources may improve the understanding of COVID-19 vaccine safety. Using a unique dataset from Israel National Emergency Medical Services (EMS) from 2019 to 2021, the study aims… Continue reading Increased emergency cardiovascular events among under-40 population in Israel during vaccine rollout and third COVID-19 wave
Analysis of Aspirin Use and Cardiovascular Events and Mortality Among Adults With Hypertension and Controlled Systolic Blood Pressure
Aspirin use for the primary prevention of atherosclerotic cardiovascular disease (ASCVD) has been questioned for having limited benefit in individuals with diabetes,1 neutral outcomes in individuals at low risk,2 and increased bleeding risk and mortality in healthy older individuals.3,4 Given the lack of specific updated evidence, we aimed to investigate whether aspirin use alongside guideline-directed… Continue reading Analysis of Aspirin Use and Cardiovascular Events and Mortality Among Adults With Hypertension and Controlled Systolic Blood Pressure
Avocado Consumption and Risk of Cardiovascular Disease in US Adults
AbstractBackgroundEpidemiologic studies on the relationship between avocado intake and long‐term cardiovascular disease (CVD) risk are lacking. Methods and ResultsThis study included 68 786 women from the NHS (Nurses’ Health Study) and 41 701 men from the HPFS (Health Professionals Follow‐up Study; 1986–2016) who were free of cancer, coronary heart disease, and stroke at baseline. Diet… Continue reading Avocado Consumption and Risk of Cardiovascular Disease in US Adults
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