Estrogen receptor (ER) testing of breast cancer imperfectly predicts response to endocrine therapy (ET). We hypothesize that a brief estradiol challenge will increase tumor progesterone receptor (PgR) levels only in tumors with functional ER. In this prospective, phase 2, single-center, single-arm trial (NCT02455453), we report the association of response to ET with change in tumor… Continue reading Association of #PET-based #estradiol-challenge test for #breast cancer progesterone receptors with response to endocrine therapy
Tag: cancer
NAD+ depletion by type I interferon signaling sensitizes #pancreatic cancer cells to NAMPT inhibition
Emerging evidence suggests that intratumoral interferon (IFN) signaling can trigger targetable vulnerabilities. A hallmark of pancreatic ductal adenocarcinoma (PDAC) is its extensively reprogrammed metabolic network, in which nicotinamide adenine dinucleotide (NAD) and its reduced form, NADH, are critical cofactors. Here, we show that IFN signaling, present in a subset of PDAC tumors, substantially lowers NAD(H)… Continue reading NAD+ depletion by type I interferon signaling sensitizes #pancreatic cancer cells to NAMPT inhibition
Calculated indices of volatile organic compounds (VOCs) in exhalation for #lung #cancer screening and early detection
Breath analysis is a promising noninvasive technique that offers a wide range of opportunities to facilitate early diagnosis of lung cancer (LC). Method Exhaled breath samples of 352 subjects including 160 with lung cancer (LC), 70 with benign pulmonary nodule (BPN) and 122 healthy controls (HC) were analyzed through thermal desorption coupled with gas chromatography-mass… Continue reading Calculated indices of volatile organic compounds (VOCs) in exhalation for #lung #cancer screening and early detection
Incorporating Baseline Breast #Density When Screening Women at Average Risk for #Breast Cancer
..Intervention: No screening; biennial or triennial mammography from age 50 to 75 years; annual mammography from age 50 to 75 years for women with dense breasts at age 50 years and biennial or triennial mammography from age 50 to 75 years for those without dense breasts at age 50 years; and annual mammography at age… Continue reading Incorporating Baseline Breast #Density When Screening Women at Average Risk for #Breast Cancer
#Ovarian cancer risk in relation to blood #lipid levels and hyperlipidemia: a systematic review and meta-analysis of observational epidemiologic studies
Epidemiologic evidence regarding association of ovarian cancer risk with blood lipid level and hyperlipidemia is inconsistent. We aimed to synthesize available epidemiologic studies to disentangle associations of cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and hyperlipidemia with ovarian cancer risk. We searched PubMed, EMBASE, and Web of Science for eligible studies. A… Continue reading #Ovarian cancer risk in relation to blood #lipid levels and hyperlipidemia: a systematic review and meta-analysis of observational epidemiologic studies
Drug-specific and dosage effects of #statins and the risk of #cancer: a population-based cohort study in South Korea
This study aimed to investigate whether the drug-specific and dosage effects of statin use were associated with a lower risk of cancer in adults in South Korea. We evaluated the adult population registered in the 2010 sample cohort database of South Korea. Subjects were divided into the statin group (those who had been prescribed continuous… Continue reading Drug-specific and dosage effects of #statins and the risk of #cancer: a population-based cohort study in South Korea
Time-restricted #feeding normalizes hyperinsulinemia to inhibit #breast cancer in obese postmenopausal mouse models
Accumulating evidence indicates that obesity with its associated metabolic dysregulation, including hyperinsulinemia and aberrant circadian rhythms, increases the risk for a variety of cancers including postmenopausal breast cancer. Caloric restriction can ameliorate the harmful metabolic effects of obesity and inhibit cancer progression but is difficult to implement and maintain outside of the clinic. In this… Continue reading Time-restricted #feeding normalizes hyperinsulinemia to inhibit #breast cancer in obese postmenopausal mouse models
Individualizing Surveillance #Mammography for Older Patients After Treatment for Early-Stage #Breast Cancer Multidisciplinary Expert Panel and International Society of Geriatric Oncology Consensus Statement
..After a literature review of the risk of ipsilateral and contralateral breast cancer events among breast cancer survivors and the harms and benefits associated with mammography, a multidisciplinary expert panel was convened to develop consensus guidelines on surveillance mammography for breast cancer survivors 75 years or older. Using an iterative consensus-based approach, input from clinician… Continue reading Individualizing Surveillance #Mammography for Older Patients After Treatment for Early-Stage #Breast Cancer Multidisciplinary Expert Panel and International Society of Geriatric Oncology Consensus Statement
#Benzophenone-3 promotion of mammary tumorigenesis is diet-dependent
Benzophenone-3 is a putative endocrine disrupting chemical and common ingredient in sunscreens. The potential of endocrine disrupting chemicals to act as agonists or antagonists in critical hormonally regulated processes, such as mammary gland development and mammary tumorigenesis, demands evaluation of its potential in promoting breast cancer. This study identifies the effects of BP-3 on mammary… Continue reading #Benzophenone-3 promotion of mammary tumorigenesis is diet-dependent
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