Camel milk has demonstrated robust immunomodulatory and anti-inflammatory properties in various clinical and experimental studies. However, no previous studies have characterized the cellular immunological effects of camel milk in the context of allergic asthma. Therefore, the present work aimed to evaluate the protective effects of camel milk in house dust mite induced asthma in mice,… Continue reading The effect of #camel #milk on house dust mite allergen induced #asthma model in BALB/C mice
Tag: asthma
A new era in the treatment of acute exacerbations of #asthma and #COPD
Nearly 4 million patients with chronic obstructive pulmonary disease (COPD) or asthma die each year, mostly from severe acute exacerbations.1 For the past 60 years, systemic corticosteroids have been the mainstay treatment of acute exacerbations.2 However, they confer only modest beneficial effects and are fraught with many adverse health effects including adrenal insufficiency, osteoporosis, and… Continue reading A new era in the treatment of acute exacerbations of #asthma and #COPD
#Antibiotic-driven #dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates #allergic airway inflammation in adulthood
•Early-life antibiotics increase the risk of allergy in adulthood•Antibiotics cause short-term disruption of the microbiome and systemic metabolome•Dysfunctional mitochondria in the airway epithelium lead to exaggerated inflammation•Indole-3-propionic acid counters the detrimental effects of early-life antibioticsSummaryAntibiotic use in early life disrupts microbial colonization and increases the risk of developing allergies and asthma. We report that mice… Continue reading #Antibiotic-driven #dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates #allergic airway inflammation in adulthood
Use of digital measurement of medication adherence and lung function to guide the management of uncontrolled asthma (INCA Sun): a multicentre, single-blinded, randomised clinical trial
The clinical value of using digital tools to assess adherence and lung function in uncontrolled asthma is not known. We aimed to compare treatment decisions guided by digitally acquired data on adherence, inhaler technique, and peak flow with existing methods.MethodsA 32-week prospective, multicentre, single-blinded, parallel, randomly controlled trial was done in ten severe asthma clinics… Continue reading Use of digital measurement of medication adherence and lung function to guide the management of uncontrolled asthma (INCA Sun): a multicentre, single-blinded, randomised clinical trial
Increased risk of osteoarthritis in patients with atopic disease
Objectives To determine the incidence of osteoarthrits (OA) in patients with atopic disease compared with matched non-exposed patients.Methods We conducted a retrospective cohort study with propensity score matching using claims data from Optum’s de-identified Clinformatics Data Mart (CDM) (January 2003 to June 2019) and electronic health record data from the Stanford Research Repository (STARR) (January 2010 to… Continue reading Increased risk of osteoarthritis in patients with atopic disease
Cannabis legalization and childhood asthma in the United States: An ecologic analysis
Cannabis use is increasing among adults with children in the home particularly in states with cannabis legalization for medical (MCL) and/or recreational use (RCL), relative to states where cannabis use remains illegal at the state level. Exposure to secondhand smoke is a key risk factor for asthma among children. The objective of the current study… Continue reading Cannabis legalization and childhood asthma in the United States: An ecologic analysis
Sputum Type 2 Markers Could Predict Remission in Severe Asthma Treated With Anti-IL-5
Biotherapies targeting IL-5 allow a tangible improvement of asthma. However, all patients do not respond the same way to these treatments. Even if high blood eosinophil counts seem to be associated with a reduction in exacerbations with treatment targeting IL-5, we lack biomarkers for the prediction of remission after these very expensive treatments.Research QuestionDoes the… Continue reading Sputum Type 2 Markers Could Predict Remission in Severe Asthma Treated With Anti-IL-5
Persistent Asthma Is Associated With Carotid Plaque in MESA
BackgroundAsthma and atherosclerotic cardiovascular disease share an underlying inflammatory pathophysiology. We hypothesized that persistent asthma is associated with carotid plaque burden, a strong predictor of atherosclerotic cardiovascular disease events.Methods and ResultsThe MESA (Multi‐Ethnic Study of Atherosclerosis) enrolled adults free of known atherosclerotic cardiovascular disease at baseline. Subtype of asthma was determined at examination 1. Persistent… Continue reading Persistent Asthma Is Associated With Carotid Plaque in MESA
Association Between Aluminum Exposure From Vaccines Before Age 24 Months and Persistent Asthma at Age 24 to 59 Months
ObjectiveTo assess the association between cumulative aluminum exposure from vaccines before age 24 months and persistent asthma at age 24 to 59 months.MethodsA retrospective cohort study was conducted in the Vaccine Safety Datalink (VSD). Vaccination histories were used to calculate cumulative vaccine-associated aluminum in milligrams (mg). The persistent asthma definition required one inpatient or 2 outpatient asthma… Continue reading Association Between Aluminum Exposure From Vaccines Before Age 24 Months and Persistent Asthma at Age 24 to 59 Months
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