Use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been hypothesized to be associated with reduced risk of breast cancer; however, results of epidemiological studies have been mixed. Few studies have investigated these associations among African American women.. To assess the relation of aspirin use to risk of breast cancer in African American women,… Continue reading #Aspirin use and risk of #breast cancer in African American women
Tag: Aspirin
#Aspirin with or without #Clopidogrel after Transcatheter Aortic- #Valve Implantation
The effect of single as compared with dual antiplatelet treatment on bleeding and thromboembolic events after transcatheter aortic-valve implantation (TAVI) in patients who do not have an indication for long-term anticoagulation has not been well studied.. ..A total of 331 patients were assigned to receive aspirin alone and 334 were assigned to receive aspirin plus… Continue reading #Aspirin with or without #Clopidogrel after Transcatheter Aortic- #Valve Implantation
#Coronary Artery Calcium for Personalized Allocation of #Aspirin in Primary Prevention of Cardiovascular Disease in 2019: The Multi-Ethnic Study of Atherosclerosis (MESA)
..The present study aimed to assess the value of coronary artery calcium (CAC) for guiding aspirin allocation for primary prevention using 2019 aspirin meta-analysis data on CVD relative risk reduction (RRR) and bleeding risk ..Only 5% of MESA participants would qualify for aspirin consideration for primary prevention according to ACC/AHA guidelines and using >20% estimated… Continue reading #Coronary Artery Calcium for Personalized Allocation of #Aspirin in Primary Prevention of Cardiovascular Disease in 2019: The Multi-Ethnic Study of Atherosclerosis (MESA)
#Aspirin for primary prevention of cardiovascular disease, part 2
..ASPREE study suggests no benefit from aspirin in primary prevention ASPREE randomized 19,114 healthy people 70 or over (65 or over for African Americans and Hispanics) to receive either 100 milligrams of enteric-coated aspirin or placebo. After an average of almost five years, there was no significant difference in the rate of fatal coronary heart… Continue reading #Aspirin for primary prevention of cardiovascular disease, part 2
Clinical Influence of Nonadherence With Prophylactic #Aspirin in Preventing #Preeclampsia in High-Risk Pregnancies
..Women with inadequate adherence had higher incidence of early-onset preeclampsia (17% versus 2%; odds ratio [OR], 1.9 [95% CI, 1.1–8.7]; P=0.04), late-onset preeclampsia (41% versus 5%; OR, 4.2 [95% CI, 1.4–19.8]; P=0.04), intrauterine growth restriction (29% versus 5%; OR, 5.8; [95% CI, 1.2–8.3]; P=0.001), preterm delivery (27% versus 10%; OR, 5.2 [95% CI, 1.5–8.7]; P=0.008),… Continue reading Clinical Influence of Nonadherence With Prophylactic #Aspirin in Preventing #Preeclampsia in High-Risk Pregnancies
Clinical Effectiveness and Safety of #Aspirin for Venous #Thromboembolism Prophylaxis After Total Hip and Knee Replacement
Patients undergoing total hip replacement (THR) and total knee replacement (TKR) receive venous thromboembolism (VTE) pharmacoprophylaxis. It is unclear which anticoagulant is preferable. Observational data suggest aspirin provides effective VTE prophylaxis.. ..The RR of VTE after THR and TKR was 1.12 (95% CI, 0.78-1.62) for aspirin compared with other anticoagulants. Comparable findings were observed for… Continue reading Clinical Effectiveness and Safety of #Aspirin for Venous #Thromboembolism Prophylaxis After Total Hip and Knee Replacement
#Aspirin and #fracture risk: a systematic review and exploratory meta-analysis of observational studies
This review provides insights into the potential for aspirin to preserve bone mineral density (BMD) and reduce fracture risk, building knowledge of the risk-benefit profile of aspirin. ..Aspirin use was associated with a 17% lower odds for any fracture (OR 0.83, 95% CI 0.70 to 0.99; I2=71%; six studies; n=511 390). Aspirin was associated with a higher… Continue reading #Aspirin and #fracture risk: a systematic review and exploratory meta-analysis of observational studies
Low‐Dose #Aspirin for Primary Prevention of #Cardiovascular Disease: Use Patterns and Impact Across Race and Ethnicity in the Southern Community Cohort Study
..Over a median follow‐up of 11.3 years, low‐dose aspirin use was associated with a trend toward decreased risk of ischemic cardiac death in white participants (adjusted hazard ratio: 0.86; 95% CI, 0.68–1.10), especially in women (adjusted hazard ratio: 0.72; 95% CI, 0.51–1.02), but not in black participants (adjusted hazard ratio: 1.18; 95% CI, 0.98–1.40). Similar… Continue reading Low‐Dose #Aspirin for Primary Prevention of #Cardiovascular Disease: Use Patterns and Impact Across Race and Ethnicity in the Southern Community Cohort Study
#Aspirin for primary #prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups
..major adverse cardiovascular events (MACE) ..Aspirin use did not translate into a net clinical benefit adjusted for event-associated mortality risk (mean 0.034%; 95% CI, − 0.18 to 0.25%). There was an interaction for aspirin effect in three patient subgroups: (i) in patients under statin treatment, aspirin was associated with a 12% RRR of MACE (RR 0.88;… Continue reading #Aspirin for primary #prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups
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