..Adherence to the diet was associated with specific microbiome alterations. Taxa enriched by adherence to the diet were positively associated with several markers of lower frailty and improved cognitive function, and negatively associated with inflammatory markers including C-reactive protein and interleukin-17. Analysis of the inferred microbial metabolite profiles indicated that the diet-modulated microbiome change was… Continue reading #Mediterranean diet intervention alters the gut microbiome in older people reducing #frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries
Mitigation of nonalcoholic #fatty liver disease in high-fat-fed mice by the combination of decaffeinated green tea extract and voluntary exercise
We have shown that combination treatment with decaffeinated green tea extract (GTE) and voluntary exercise (Ex) reduces obesity and insulin resistance in high-fat (HF)-fed mice to a greater extent than either treatment alone. Here, we investigated the effects of GTE-, Ex- or the combination on the development of obesity-related NAFLD.. ..Combination treated, but not singly… Continue reading Mitigation of nonalcoholic #fatty liver disease in high-fat-fed mice by the combination of decaffeinated green tea extract and voluntary exercise
#Hand‐Hygiene Mitigation Strategies Against Global #Disease Spreading through the Air Transportation Network
The risk for a global transmission of flu‐type viruses is strengthened by the physical contact between humans and accelerated through individual mobility patterns.. ..Here, we use epidemiological modeling and data‐driven simulations to elucidate the role of individual engagement with hand hygiene inside airports in conjunction with human travel on the global spread of epidemics. We… Continue reading #Hand‐Hygiene Mitigation Strategies Against Global #Disease Spreading through the Air Transportation Network
Efficacy and Safety of #Lanabecestat for Treatment of Early and Mild #Alzheimer Disease
Does lanabecestat, a potent inhibitor of the beta-site amyloid precursor protein–cleaving enzyme 1 (BACE1), slow the progression of early Alzheimer disease (AD) and mild AD dementia?.. ..Among 1722 DAYBREAK-ALZ patients, the mean (SD) age was 72.3 (7.0) years, and 1023 of 1722 (59.4%) were women. Both studies were terminated early after futility analysis. There were… Continue reading Efficacy and Safety of #Lanabecestat for Treatment of Early and Mild #Alzheimer Disease
#Nut Consumption and Risk of #Cancer: A Meta-analysis of Prospective Studies
..When comparing the highest with the lowest category of nut intake, high consumption of nuts was significantly associated with decreased risk of overall cancer (RR = 0.90; 95% CI, 0.85–0.95). The protective effect of nut consumption was especially apparent against cancers from the digestive system (RR = 0.83; 95% CI, 0.77–0.89). Among different nut classes,… Continue reading #Nut Consumption and Risk of #Cancer: A Meta-analysis of Prospective Studies
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel #Coronavirus–Infected Pneumonia in Wuhan, China
..Of 138 hospitalized patients with NCIP, the median age was 56 years (interquartile range, 42-68; range, 22-92 years) and 75 (54.3%) were men. Hospital-associated transmission was suspected as the presumed mechanism of infection for affected health professionals (40 [29%]) and hospitalized patients (17 [12.3%]). Common symptoms included fever (136 [98.6%]), fatigue (96 [69.6%]), and dry… Continue reading Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel #Coronavirus–Infected Pneumonia in Wuhan, China
#Shift Workers at Risk for #Metabolic Syndrome
In this highly digitalized era, sleep disorders are becoming more common and are associated with an increased burden of chronic disease. Shift workers are at an increased risk for both sleep disorders and metabolic syndrome. In this article, the authors outline the connection between circadian discordance, hormonal imbalance, and the development of metabolic syndrome in… Continue reading #Shift Workers at Risk for #Metabolic Syndrome
Thalamic Gamma Aminobutyric Acid Level Changes in Major #Depressive Disorder After a 12-Week Iyengar Yoga and Coherent #Breathing Intervention
To determine if a 12-week yoga intervention (YI) was associated with increased gamma aminobutyric acid (GABA) levels and decreased depressive symptoms in participants with major depressive disorder (MDD). Subjects were randomized to a high-dose group (HDG) of three YIs a week and a low-dose group (LDG) of two YIs a week. ..BDI-II scores improved significantly… Continue reading Thalamic Gamma Aminobutyric Acid Level Changes in Major #Depressive Disorder After a 12-Week Iyengar Yoga and Coherent #Breathing Intervention
The Psychophysiological Effects of Different Tempo #Music on Endurance Versus High-Intensity #Performances
..This study assessed 19 active women (age 26.4 ± 2.6 years) during endurance (walking for 10′ at 6.5 km/h on a treadmill) and high intensity (80% on 1-RM) exercise under four different randomly assigned conditions: no music (NM), with music at 90–110 bpm (LOW), with music at 130–150 bpm (MED), and with music at 170–190… Continue reading The Psychophysiological Effects of Different Tempo #Music on Endurance Versus High-Intensity #Performances
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