Yue, Luo, and colleagues discovered that adenosine signalling is the common underlying mechanism of rapid acting antidepressant therapies, unifying the effects of ketamine, ECT and acute intermittent hypoxia. They use genetically encoded sensors, along with extensive mechanistic dissection, to show that all three induce adenosine surges in mood-regulatory circuits via A1 and A2A receptor activation.… Continue reading #Adenosine as the metabolic common path of rapid #antidepressant action: The #coffee paradox
Category: psychology
Mapping multimodal risk factors to #mental health outcomes
A key challenge in predicting a person’s state of mind is that a wide range of contributing factors each has a subtle, yet meaningful, influence on mental health. Here we applied data mining techniques to identify the most important risk factors for predicting current symptoms and longitudinal outcomes from the Adolescent Brain Cognitive Developmental study… Continue reading Mapping multimodal risk factors to #mental health outcomes
Unlocking deep #relaxation: the power of #rhythmic #breathing on brain rhythms
The pandemic has exacerbated mental health issues across the world. The limited availability of mental health professionals is preventing many from seeking help, which highlights the need for easily available mental health care routines like yoga, breathing, and meditation. A breath-based meditation technique known as Sudarshan Kriya #Yoga (SKY) harnesses the power of breath to… Continue reading Unlocking deep #relaxation: the power of #rhythmic #breathing on brain rhythms
#Emotion regulation strategies differentially impact memory in #hormonal #contraceptive users
Highlights•HC users show greater emotional reactivity compared to NC females.•Distancing reduces negative affect in HC users compared to NC females.•HC users exhibit memory modulation for emotional images by emotion regulation. AbstractHormonal contraceptives (HCs) are widely used, yet their effects on emotional and cognitive processes remain poorly understood. This study examined how HC use may influence… Continue reading #Emotion regulation strategies differentially impact memory in #hormonal #contraceptive users
Psychosocial #stress amplifies inflammation through NLRP3 Inflammasome activated by endoplasmic reticulum stress in the mouse #heart
Psychosocial stress (PSS) is a significant contributor of inflammation and CVD.• NLRP3 inflammasome activation amplifies inflammation in response to PSS.• ER stress is a key upstream mechanism that triggers NLRP3 inflammasome activation.• This study reveals mechanisms and targets to reduce inflammation caused by PSS. AbstractPsychosocial stress (PSS) affects all humans with different intensities and is… Continue reading Psychosocial #stress amplifies inflammation through NLRP3 Inflammasome activated by endoplasmic reticulum stress in the mouse #heart
The declining #mental #health of the #young and the global disappearance of the #unhappiness hump shape in #age
Across many studies subjective well-being has followed a U-shape in age, declining until people reach middle-age, only to rebound subsequently. Ill-being has followed a mirror-imaged hump-shape. Using graphical and regression analyses of repeat cross-sectional micro-data from the United States and the United Kingdom, we show this empirical regularity has been replaced by a monotonic decrease… Continue reading The declining #mental #health of the #young and the global disappearance of the #unhappiness hump shape in #age
#Mineral Intake and #Depression: A Cross-Sectional Comparative Study Based on National Health and Nutrition Examination Surveys in Korea and the United States
Background/Objectives: Depression is a major global health burden, and previous studies suggest that nutrient deficiencies may contribute to its development. However, research on mineral intake and depression, particularly sodium and potassium, is limited. We conducted a cross-sectional analysis of data from the National Health and Nutrition Examination Survey in Korea (KNHANES) and the United States… Continue reading #Mineral Intake and #Depression: A Cross-Sectional Comparative Study Based on National Health and Nutrition Examination Surveys in Korea and the United States
#Limbic gray matter increases in response to #cognitive-behavioral therapy in major #depressive disorder
Major depressive disorder (MDD) is related to volumetric decreases in (cortico-)limbic brain regions. In contrast to pharmacological and electroconvulsive therapy, little is known about the brain structural effects of psychotherapy and potential links to symptom improvements. In a naturalistic longitudinal study using structural magnetic resonance tomography, gray matter volume (GMV) and clinical measures were assessed… Continue reading #Limbic gray matter increases in response to #cognitive-behavioral therapy in major #depressive disorder
#432 Hz Frequency Benefits: A Comprehensive Guide
#Music has always held the power to move, heal, and inspire. But beyond melody and rhythm, the frequencies at which music is tuned can also influence how it affects us. One frequency, in particular, has captured the imagination of musicians, healers, and sound therapists around the world: 432 Hz. Often referred to as the "natural… Continue reading #432 Hz Frequency Benefits: A Comprehensive Guide
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