BackgroundPosttraumatic stress disorder (PTSD) is common and debilitating, and many individuals do not respond to existing therapies. We developed a fundamentally novel neuromodulation-based therapy for treatment-resistant PTSD. This approach is premised on coupling prolonged exposure therapy, a first-line evidence-based cognitive behavioral therapy that directs changes within fear networks, with concurrent delivery of short bursts of… Continue reading #Vagus nerve stimulation therapy for treatment-resistant #PTSD
Category: Psychiatry
#Probiotics reduce negative #mood over time: the value of daily self-reports in detecting effects
The burgeoning field of the microbiome–gut–brain axis has inspired research into how the gut microbiome can affect human emotion. Probiotics offer ways to investigate microbial-based interventions but results have been mixed, with more evidence of beneficial effects in clinically depressed patients. Using a randomised, double-blind, placebo-controlled design in 88 healthy volunteers, we conduct a comprehensive… Continue reading #Probiotics reduce negative #mood over time: the value of daily self-reports in detecting effects
Postpartum Hormonal #Contraceptive Use and Risk of #Depression
AbstractImportance Hormonal contraceptive (HC) use is associated with depression. It is, however, unknown whether this is also true in the postpartum period when women have a heightened depression risk and are routinely offered HC treatment.Objective To examine whether HC initiation post partum is associated with the development of depression within 12 months post partum.Design, Setting,… Continue reading Postpartum Hormonal #Contraceptive Use and Risk of #Depression
High- #salt #diet drives depression-like behavior in mice by inducing IL-17A production
Major depression disorder is a common illness that severely limits psychosocial functioning, affects outcomes of other diseases, and diminishes the quality of life. High-salt diet (HSD) has long been closely associated with the occurrence and development of depression, but whether or how HSD causes depression remains unclear. In this study, HSD induces depression-like behavior in… Continue reading High- #salt #diet drives depression-like behavior in mice by inducing IL-17A production
#Life expectancy and years of life lost for adults with diagnosed #ADHD in the UK: matched cohort study
Nearly 3% of adults have attention-deficit and hyperactivity disorder (ADHD), although in the UK, most are undiagnosed. Adults with ADHD on average experience poorer educational and employment outcomes, worse physical and mental health and are more likely to die prematurely. No studies have yet used mortality data to examine the life expectancy deficit experienced by… Continue reading #Life expectancy and years of life lost for adults with diagnosed #ADHD in the UK: matched cohort study
Glucagon-Like Peptide-1 Receptor Agonists and Risk for #Depression in Older Adults With Type 2 #Diabetes
Background:Although glucagon-like peptide-1 receptor agonists (GLP-1RAs) have shown potential antidepressant effects, population studies yield inconsistent results. Objective:To compare the risk for depression in older adults with type 2 diabetes (T2D) initiating treatment with GLP-1RAs versus sodium–glucose cotransporter-2 inhibitors (SGLT2is) or dipeptidyl peptidase-4 inhibitors (DPP4is).Design:Target trial emulation study.Setting:U.S. National Medicare administrative data from January 2014 to… Continue reading Glucagon-Like Peptide-1 Receptor Agonists and Risk for #Depression in Older Adults With Type 2 #Diabetes
Real-Time Assessment of #Alcohol Reward, Stimulation, and Negative Affect in Individuals With and Without Alcohol Use Disorder and #Depressive Disorders
Objective:The allostasis theory states that, as addiction develops, alcohol is consumed to relieve negative affect rather than to produce positive effects. This study aimed to investigate the real-time subjective effects of alcohol in individuals with alcohol use disorder (AUD) and those prone to negative affect by virtue of having comorbid depressive disorder (DEP).Methods:Participants (N=221) completed… Continue reading Real-Time Assessment of #Alcohol Reward, Stimulation, and Negative Affect in Individuals With and Without Alcohol Use Disorder and #Depressive Disorders
Life expectancy and years of life lost for adults with diagnosed #ADHD in the UK: matched cohort study
Nearly 3% of adults have attention-deficit and hyperactivity disorder (ADHD), although in the UK, most are undiagnosed. Adults with ADHD on average experience poorer educational and employment outcomes, worse physical and mental health and are more likely to die prematurely. No studies have yet used mortality data to examine the life expectancy deficit experienced by… Continue reading Life expectancy and years of life lost for adults with diagnosed #ADHD in the UK: matched cohort study
Application of functional near-infrared spectroscopy and #machine learning to predict treatment response after six months in major #depressive disorder
Depression treatment responses vary widely among individuals. Identifying objective biomarkers with predictive accuracy for therapeutic outcomes can enhance treatment efficiency and avoid ineffective therapies. This study investigates whether functional near-infrared spectroscopy (fNIRS) and clinical assessment information can predict treatment response in major depressive disorder (MDD) through machine-learning techniques. Seventy patients with MDD were included in… Continue reading Application of functional near-infrared spectroscopy and #machine learning to predict treatment response after six months in major #depressive disorder
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