AbstractImportance Hormonal contraceptive (HC) use is associated with depression. It is, however, unknown whether this is also true in the postpartum period when women have a heightened depression risk and are routinely offered HC treatment.Objective To examine whether HC initiation post partum is associated with the development of depression within 12 months post partum.Design, Setting,… Continue reading Postpartum Hormonal #Contraceptive Use and Risk of #Depression
Category: Psychiatry
High- #salt #diet drives depression-like behavior in mice by inducing IL-17A production
Major depression disorder is a common illness that severely limits psychosocial functioning, affects outcomes of other diseases, and diminishes the quality of life. High-salt diet (HSD) has long been closely associated with the occurrence and development of depression, but whether or how HSD causes depression remains unclear. In this study, HSD induces depression-like behavior in… Continue reading High- #salt #diet drives depression-like behavior in mice by inducing IL-17A production
#Life expectancy and years of life lost for adults with diagnosed #ADHD in the UK: matched cohort study
Nearly 3% of adults have attention-deficit and hyperactivity disorder (ADHD), although in the UK, most are undiagnosed. Adults with ADHD on average experience poorer educational and employment outcomes, worse physical and mental health and are more likely to die prematurely. No studies have yet used mortality data to examine the life expectancy deficit experienced by… Continue reading #Life expectancy and years of life lost for adults with diagnosed #ADHD in the UK: matched cohort study
Glucagon-Like Peptide-1 Receptor Agonists and Risk for #Depression in Older Adults With Type 2 #Diabetes
Background:Although glucagon-like peptide-1 receptor agonists (GLP-1RAs) have shown potential antidepressant effects, population studies yield inconsistent results. Objective:To compare the risk for depression in older adults with type 2 diabetes (T2D) initiating treatment with GLP-1RAs versus sodium–glucose cotransporter-2 inhibitors (SGLT2is) or dipeptidyl peptidase-4 inhibitors (DPP4is).Design:Target trial emulation study.Setting:U.S. National Medicare administrative data from January 2014 to… Continue reading Glucagon-Like Peptide-1 Receptor Agonists and Risk for #Depression in Older Adults With Type 2 #Diabetes
Real-Time Assessment of #Alcohol Reward, Stimulation, and Negative Affect in Individuals With and Without Alcohol Use Disorder and #Depressive Disorders
Objective:The allostasis theory states that, as addiction develops, alcohol is consumed to relieve negative affect rather than to produce positive effects. This study aimed to investigate the real-time subjective effects of alcohol in individuals with alcohol use disorder (AUD) and those prone to negative affect by virtue of having comorbid depressive disorder (DEP).Methods:Participants (N=221) completed… Continue reading Real-Time Assessment of #Alcohol Reward, Stimulation, and Negative Affect in Individuals With and Without Alcohol Use Disorder and #Depressive Disorders
Life expectancy and years of life lost for adults with diagnosed #ADHD in the UK: matched cohort study
Nearly 3% of adults have attention-deficit and hyperactivity disorder (ADHD), although in the UK, most are undiagnosed. Adults with ADHD on average experience poorer educational and employment outcomes, worse physical and mental health and are more likely to die prematurely. No studies have yet used mortality data to examine the life expectancy deficit experienced by… Continue reading Life expectancy and years of life lost for adults with diagnosed #ADHD in the UK: matched cohort study
Application of functional near-infrared spectroscopy and #machine learning to predict treatment response after six months in major #depressive disorder
Depression treatment responses vary widely among individuals. Identifying objective biomarkers with predictive accuracy for therapeutic outcomes can enhance treatment efficiency and avoid ineffective therapies. This study investigates whether functional near-infrared spectroscopy (fNIRS) and clinical assessment information can predict treatment response in major depressive disorder (MDD) through machine-learning techniques. Seventy patients with MDD were included in… Continue reading Application of functional near-infrared spectroscopy and #machine learning to predict treatment response after six months in major #depressive disorder
#Mindfulness Meditation vs #Escitalopram for Treatment of #Anxiety DisordersSecondary Analysis of a Randomized Clinical Trial
IntroductionMindfulness-based interventions, such as mindfulness-based stress reduction (MBSR), have shown efficacy for anxiety disorders.1 We previously demonstrated that 8 weeks of MBSR was noninferior to escitalopram for treatment of anxiety disorders in a fully powered, multisite, noninferiority parallel-group randomized clinical trial with a predetermined margin.2 We present secondary outcomes of the trial, including patient-reported anxiety,… Continue reading #Mindfulness Meditation vs #Escitalopram for Treatment of #Anxiety DisordersSecondary Analysis of a Randomized Clinical Trial
Clinical #EEG slowing induced by electroconvulsive therapy is better described by increased frontal aperiodic activity
Electroconvulsive therapy (ECT) is one of the most efficacious interventions for treatment-resistant depression. Despite its efficacy, ECT’s neural mechanism of action remains unknown. Although ECT has been associated with “slowing” in the electroencephalogram (EEG), how this change relates to clinical improvement is unresolved. Until now, increases in slow-frequency power have been assumed to indicate increases… Continue reading Clinical #EEG slowing induced by electroconvulsive therapy is better described by increased frontal aperiodic activity
2 Medical News 