Patients with chronic obstructive pulmonary disease (COPD) frequently suffer from other chronic conditions, with cardiovascular disease being especially common. The presence of cardiovascular disease in patients with #COPD complicates overall disease management and is associated with worse morbidity and high mortality. Furthermore, patients who are hospitalised due to a COPD exacerbation are at an increased… Continue reading From hospital to home: Practical guidance when caring for patients with COPD and heart disease
Category: Pneumology
Conditional BCL-2 Expression in Fibroblasts Promotes Persistent Pulmonary Fibrosis which is Reversible by Therapeutic BCL-2 Inhibition
Idiopathic pulmonary fibrosis ( #IPF ) is a progressive, fatal lung disease that develops in response to chronic epithelial injury. Unlike injury-induced homeostatic lung repair during which fibroblasts undergo apoptosis and clearance, the lungs of IPF patients continue to accumulate apoptosis-resistant, pro-fibrotic, extracellular matrix-producing fibroblasts. Here, we show that prevention of PDGFRα+ fibroblast apoptosis by… Continue reading Conditional BCL-2 Expression in Fibroblasts Promotes Persistent Pulmonary Fibrosis which is Reversible by Therapeutic BCL-2 Inhibition
The Role of Artificial Intelligence in Diagnosing Pulmonary Embolism: A Systematic Review and Meta-analysis
Introduction: Missed or delayed diagnosis of pulmonary embolism (#PE ) is associated with increased morbidity, mortality, and longer hospitalizations. This study aimed to evaluate the diagnostic accuracy of Artificial Intelligence (#AI ) models in detecting PE across imaging.Methods: We systematically searched PubMed/MEDLINE, Scopus, Embase and Web of Science from inception to 1 January 2025 without… Continue reading The Role of Artificial Intelligence in Diagnosing Pulmonary Embolism: A Systematic Review and Meta-analysis
Effectiveness of biologics for reducing occlusive mucus plugs in patients with severe asthma: a systematic review
Asthma is a heterogeneous disease characterized by chronic airway inflammation and reversible airflow obstruction. Particularly in severe #asthma , airway #mucus plugs can contribute to substantial and persistent airflow obstruction, despite inhaled corticosteroid and bronchodilator treatment. Consequently, it is important that clinicians assess and treat mucus plugs. Increased mucus production and airway eosinophilia caused by… Continue reading Effectiveness of biologics for reducing occlusive mucus plugs in patients with severe asthma: a systematic review
Increased Prevalence of Pulmonary Diseases in Patients With Inflammatory Bowel Disease
Inflammatory bowel disease ( #IBD ) is a multisystem illness with intestinal and extraintestinal manifestations. We aimed to analyze the association of developing #pulmonary diseases (PDs) in patients with IBD.Methods: In this retrospective cohort study, TriNetX was used to identify patients with IBD who were prescribed at least one IBD-specific medication or advanced therapy. Patients… Continue reading Increased Prevalence of Pulmonary Diseases in Patients With Inflammatory Bowel Disease
Alcohol’s Effects on the Lung and Lung Disease
Purpose: Alcohol misuse is widely accepted as an independent risk factor for a wide variety of lung diseases, such as pneumonia and acute respiratory distress syndrome. Alcohol induces changes in the regulatory mechanisms of the lung, both at a mechanical and immunological level. Understanding these changes might help discover new targets for drugs and therapeutic… Continue reading Alcohol’s Effects on the Lung and Lung Disease
Association between ultra-processed #food consumption and #lung #cancer risk: a population-based cohort study
Background The evidence on associations between ultra-processed foods (UPF) and lung cancer risk is limited and inconsistent.Research question Are UPF associated with an increased risk of lung cancer, non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC)？Methods Data of participants in this study were collected from the Prostate, Lung, Colorectal and Ovarian (PLCO)… Continue reading Association between ultra-processed #food consumption and #lung #cancer risk: a population-based cohort study
The effect of #camel #milk on house dust mite allergen induced #asthma model in BALB/C mice
Camel milk has demonstrated robust immunomodulatory and anti-inflammatory properties in various clinical and experimental studies. However, no previous studies have characterized the cellular immunological effects of camel milk in the context of allergic asthma. Therefore, the present work aimed to evaluate the protective effects of camel milk in house dust mite induced asthma in mice,… Continue reading The effect of #camel #milk on house dust mite allergen induced #asthma model in BALB/C mice
A new era in the treatment of acute exacerbations of #asthma and #COPD
Nearly 4 million patients with chronic obstructive pulmonary disease (COPD) or asthma die each year, mostly from severe acute exacerbations.1 For the past 60 years, systemic corticosteroids have been the mainstay treatment of acute exacerbations.2 However, they confer only modest beneficial effects and are fraught with many adverse health effects including adrenal insufficiency, osteoporosis, and… Continue reading A new era in the treatment of acute exacerbations of #asthma and #COPD
2 Medical News 