Asthma is a heterogeneous disease characterized by chronic airway inflammation and reversible airflow obstruction. Particularly in severe #asthma , airway #mucus plugs can contribute to substantial and persistent airflow obstruction, despite inhaled corticosteroid and bronchodilator treatment. Consequently, it is important that clinicians assess and treat mucus plugs. Increased mucus production and airway eosinophilia caused by… Continue reading Effectiveness of biologics for reducing occlusive mucus plugs in patients with severe asthma: a systematic review
Category: Pneumology
Increased Prevalence of Pulmonary Diseases in Patients With Inflammatory Bowel Disease
Inflammatory bowel disease ( #IBD ) is a multisystem illness with intestinal and extraintestinal manifestations. We aimed to analyze the association of developing #pulmonary diseases (PDs) in patients with IBD.Methods: In this retrospective cohort study, TriNetX was used to identify patients with IBD who were prescribed at least one IBD-specific medication or advanced therapy. Patients… Continue reading Increased Prevalence of Pulmonary Diseases in Patients With Inflammatory Bowel Disease
Alcohol’s Effects on the Lung and Lung Disease
Purpose: Alcohol misuse is widely accepted as an independent risk factor for a wide variety of lung diseases, such as pneumonia and acute respiratory distress syndrome. Alcohol induces changes in the regulatory mechanisms of the lung, both at a mechanical and immunological level. Understanding these changes might help discover new targets for drugs and therapeutic… Continue reading Alcohol’s Effects on the Lung and Lung Disease
Association between ultra-processed #food consumption and #lung #cancer risk: a population-based cohort study
Background The evidence on associations between ultra-processed foods (UPF) and lung cancer risk is limited and inconsistent.Research question Are UPF associated with an increased risk of lung cancer, non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC)？Methods Data of participants in this study were collected from the Prostate, Lung, Colorectal and Ovarian (PLCO)… Continue reading Association between ultra-processed #food consumption and #lung #cancer risk: a population-based cohort study
The effect of #camel #milk on house dust mite allergen induced #asthma model in BALB/C mice
Camel milk has demonstrated robust immunomodulatory and anti-inflammatory properties in various clinical and experimental studies. However, no previous studies have characterized the cellular immunological effects of camel milk in the context of allergic asthma. Therefore, the present work aimed to evaluate the protective effects of camel milk in house dust mite induced asthma in mice,… Continue reading The effect of #camel #milk on house dust mite allergen induced #asthma model in BALB/C mice
A new era in the treatment of acute exacerbations of #asthma and #COPD
Nearly 4 million patients with chronic obstructive pulmonary disease (COPD) or asthma die each year, mostly from severe acute exacerbations.1 For the past 60 years, systemic corticosteroids have been the mainstay treatment of acute exacerbations.2 However, they confer only modest beneficial effects and are fraught with many adverse health effects including adrenal insufficiency, osteoporosis, and… Continue reading A new era in the treatment of acute exacerbations of #asthma and #COPD
Sex-specific alterations in pulmonary metabolic, xenobiotic and lipid signalling pathways after #e-cigarette aerosol exposure during adolescence in mice
Background E-cigarette use is now prevalent among adolescents and young adults, raising concerns over potential adverse long-term health effects. Although it is hypothesised that e-cigarettes promote inflammation, studies have yielded conflicting evidence. Our previous work showed that JUUL, a popular e-cigarette brand, elicited minimal lung inflammation but induced significant molecular changes in adult C57BL/6 mice.Methods… Continue reading Sex-specific alterations in pulmonary metabolic, xenobiotic and lipid signalling pathways after #e-cigarette aerosol exposure during adolescence in mice
Prevalence of Critical Errors and Insufficient Peak Inspiratory Flow in Patients Hospitalized With #COPD in a Department of General Internal Medicine: A Cross-Sectional Study
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and the third leading cause of mortality worldwide.1 The pharmaceutical treatment of COPD relies mainly on the administration of medications via inhalation. However, the effectiveness of these treatments is very often hampered by the suboptimal utilization of inhalers, which may arise due to errors in… Continue reading Prevalence of Critical Errors and Insufficient Peak Inspiratory Flow in Patients Hospitalized With #COPD in a Department of General Internal Medicine: A Cross-Sectional Study
#Antibiotic-driven #dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates #allergic airway inflammation in adulthood
•Early-life antibiotics increase the risk of allergy in adulthood•Antibiotics cause short-term disruption of the microbiome and systemic metabolome•Dysfunctional mitochondria in the airway epithelium lead to exaggerated inflammation•Indole-3-propionic acid counters the detrimental effects of early-life antibioticsSummaryAntibiotic use in early life disrupts microbial colonization and increases the risk of developing allergies and asthma. We report that mice… Continue reading #Antibiotic-driven #dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates #allergic airway inflammation in adulthood
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