Joint destruction in rheumatoid arthritis (RA) includes both bone and cartilage lesions. Since joint space narrowing (JSN) is not a direct evaluation of cartilage using radiography, we aimed to examine the validity of ultrasound (US) cartilage evaluation using a semiquantitative method in patients with RA. Methods We enrolled 103 patients with RA who were in… Continue reading Finger Joint #Cartilage Evaluated by Semiquantitative #Ultrasound Score in Patients With #Rheumatoid Arthritis
Category: Orthopedy
Association between current medication use and progression of radiographic #knee #osteoarthritis: data from the Osteoarthritis Initiative
Use of specific medications may accelerate the progression of radiographic knee osteoarthritis (RKOA). Our aim was to examine the effect of medication use on the progression of RKOA. Methods We used longitudinal data from the Osteoarthritis Initiative (OAI); an observational study of risk factors for knee OA. At baseline, we selected participants with RKOA (KL… Continue reading Association between current medication use and progression of radiographic #knee #osteoarthritis: data from the Osteoarthritis Initiative
Association of Potent and Very Potent Topical #Corticosteroids and the Risk of #Osteoporosis and Major Osteoporotic Fractures
Systemic and inhaled corticosteroids negatively affect bone remodeling and cause osteoporosis and bone fracture when given continuously or in high doses. However, risk of osteoporosis and major osteoporotic fracture (MOF) after application of topical corticosteroids (TCSs) is largely unexplored.. ..A total of 723 251 adults treated with the equivalent of at least 200 g of mometasone… Continue reading Association of Potent and Very Potent Topical #Corticosteroids and the Risk of #Osteoporosis and Major Osteoporotic Fractures
Efficacy and safety of #antidepressants for the treatment of back pain and #osteoarthritis: systematic review and meta-analysis
.. 33 trials (5318 participants) were included. Moderate certainty evidence showed that serotonin-noradrenaline reuptake inhibitors (SNRIs) reduced back pain (mean difference −5.30, 95% confidence interval −7.31 to −3.30) at 3-13 weeks and low certainty evidence that SNRIs reduced osteoarthritis pain (−9.72, −12.75 to −6.69) at 3-13 weeks. Very low certainty evidence showed that SNRIs reduced… Continue reading Efficacy and safety of #antidepressants for the treatment of back pain and #osteoarthritis: systematic review and meta-analysis
Effect of #denosumab on osteolytic lesion activity after total #hip arthroplasty: a single-centre, randomised, double-blind, placebo-controlled, proof of concept trial
Osteolysis causes recurrent pain and disability after total hip arthroplasty. We investigated the effect of the human monoclonal antibody denosumab on osteolytic lesion activity in patients undergoing revision total hip arthroplasty surgery to show the biological proof of concept for a non-surgical treatment for the disease.. Findings Between Dec 12, 2012, and June 24, 2018,… Continue reading Effect of #denosumab on osteolytic lesion activity after total #hip arthroplasty: a single-centre, randomised, double-blind, placebo-controlled, proof of concept trial
The Effect of Flat Flexible Versus Stable Supportive #Shoes on Knee #Osteoarthritis Symptoms
Experts recommend that persons with knee osteoarthritis wear stable supportive shoes; however, evidence suggests that flat flexible shoes may be more beneficial.. ..Of 164 participants recruited, 161 (98%) completed 6-month primary outcomes. No evidence was found that flat flexible shoes were superior to stable supportive shoes in primary outcomes. Evidence did show a between-group difference… Continue reading The Effect of Flat Flexible Versus Stable Supportive #Shoes on Knee #Osteoarthritis Symptoms
Responsiveness of the PROMIS-29 Scales in Individuals With Chronic Low #Back Pain
..The PROMIS-29 questionnaire assesses seven health-related quality-of-life domains. However, research to evaluate the responsiveness and MCIDs of the PROMS-29 scores in individuals with low back pain is limited. Methods. The study was conducted in physical therapy clinics in Thailand, using validated Thai versions of the study measures. One hundred and eighty-three individuals with chronic low… Continue reading Responsiveness of the PROMIS-29 Scales in Individuals With Chronic Low #Back Pain
#Vegetarian and #vegan diets and risks of total and site-specific #fractures: results from the prospective EPIC-Oxford study
There is limited prospective evidence on possible differences in fracture risks between vegetarians, vegans, and non-vegetarians. We aimed to study this in a prospective cohort with a large proportion of non-meat eaters.. ..Compared with meat eaters and after adjustment for socio-economic factors, lifestyle confounders, and body mass index (BMI), the risks of hip fracture were… Continue reading #Vegetarian and #vegan diets and risks of total and site-specific #fractures: results from the prospective EPIC-Oxford study
Chronic Obstructive #Pulmonary Disease and Incidence of #Hip Fracture: A Nested Case–Control Study in the EpiChron Cohort
To determine whether chronic obstructive pulmonary disease (COPD) is a risk factor for hip fracture and identify other factors associated with hip fracture. Patients and Methods: Observational nested case–control study was conducted in Aragon, Spain in 2010. We included COPD patients aged > 40 years, in the EpiChron cohort. Each COPD patient was matched for… Continue reading Chronic Obstructive #Pulmonary Disease and Incidence of #Hip Fracture: A Nested Case–Control Study in the EpiChron Cohort
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