UHRF1 maintains DNA methylation by recruiting DNA methyltransferases to chromatin. In mouse, these dynamics are potently antagonized by a natural UHRF1 inhibitory protein STELLA, while the comparable effects of its human ortholog are insufficiently characterized, especially in cancer cells. Herein, we demonstrate that human STELLA (hSTELLA) is inadequate, while mouse STELLA (mSTELLA) is fully proficient… Continue reading Defining ortholog-specific UHRF1 inhibition by STELLA for #cancer therapy
Category: Oncology
PIN1 prolyl isomerase promotes initiation and progression of #bladder cancer through the SREBP2-mediated #cholesterol biosynthesis pathway
Identities of functional pSer/Thr.Pro protein substrates of the PIN1 prolyl isomerase and its effects on downstream signaling in bladder carcinogenesis remain largely unknown. Phenotypically, we found that PIN1 positively regulated bladder cancer cell proliferation, cell motility and urothelium clearance capacity in vitro and controlled tumor growth and potential metastasis in vivo. Mechanistically, we observed a… Continue reading PIN1 prolyl isomerase promotes initiation and progression of #bladder cancer through the SREBP2-mediated #cholesterol biosynthesis pathway
Association between recorded #physical activity and cancer progression or mortality in individuals diagnosed with #cancer in South Africa
Objectives This study aimed to determine the association between progression and mortality in individuals with stage 1 cancer and their recorded physical activity before the diagnosis of the cancer.Methods We included 28 248 members with stage 1 cancers enrolled in an oncology programme in South Africa. Physical activity was recorded using fitness devices, logged gym sessions… Continue reading Association between recorded #physical activity and cancer progression or mortality in individuals diagnosed with #cancer in South Africa
Transarterial #chemoembolisation combined with lenvatinib plus pembrolizumab versus dual placebo for unresectable, non-metastatic #hepatocellular carcinoma (LEAP-012): a multicentre, randomised, double-blind, phase 3 study
BackgroundTransarterial chemoembolisation (TACE) is standard care for unresectable, non-metastatic hepatocellular carcinoma. We aimed to evaluate the addition of lenvatinib and pembrolizumab to TACE versus dual placebo plus TACE in patients with unresectable, non-metastatic hepatocellular carcinoma.MethodsIn this multicentre, randomised, double-blind, phase 3 study (LEAP-012), patients were recruited from 137 global sites in 33 countries or regions.… Continue reading Transarterial #chemoembolisation combined with lenvatinib plus pembrolizumab versus dual placebo for unresectable, non-metastatic #hepatocellular carcinoma (LEAP-012): a multicentre, randomised, double-blind, phase 3 study
Stereotactic Body Radiotherapy vs #Sorafenib Alone in #Hepatocellular Carcinoma
Question Does stereotactic body radiation therapy (SBRT) prior to systemic therapy improve overall survival compared with systemic therapy alone in patients with locally advanced hepatocellular carcinoma (HCC)?Findings This phase 3 randomized clinical trial found that the use of SBRT prior to sorafenib was associated with clinically important but not statistically significant improved overall survival in… Continue reading Stereotactic Body Radiotherapy vs #Sorafenib Alone in #Hepatocellular Carcinoma
Dietary #fructose enhances #tumour growth indirectly via interorgan lipid transfer
Fructose consumption has increased considerably over the past five decades, largely due to the widespread use of high-fructose corn syrup as a sweetener1. It has been proposed that fructose promotes the growth of some tumours directly by serving as a fuel2,3. Here we show that fructose supplementation enhances tumour growth in animal models of melanoma,… Continue reading Dietary #fructose enhances #tumour growth indirectly via interorgan lipid transfer
Associations of plasma omega-6 and omega-3 #fatty acids with overall and 19 site-specific #cancers: A population-based cohort study in UK Biobank
AbstractPrevious epidemiological studies on the associations between polyunsaturated fatty acids (PUFAs) and cancer incidence have been inconsistent. We investigated the associations of plasma omega-3 and omega-6 PUFAs with the incidence of overall and 19 site-specific cancers in a large prospective cohort. 253,138 eligible UK Biobank participants were included in our study. With a mean follow-up… Continue reading Associations of plasma omega-6 and omega-3 #fatty acids with overall and 19 site-specific #cancers: A population-based cohort study in UK Biobank
#Aspirin Use and Incidence of #Colorectal Cancer According to Lifestyle Risk
Importance Aspirin reduces the risk of colorectal cancer (CRC). Identifying individuals more likely to benefit from regular aspirin use for CRC prevention is a high priority.Objective To assess whether aspirin use is associated with the risk of CRC across different lifestyle risk factors.Design, Setting, and Participants A prospective cohort study among women in the Nurses’ Health Study (1980-2018)… Continue reading #Aspirin Use and Incidence of #Colorectal Cancer According to Lifestyle Risk
Deep learning assists detection of #esophageal #cancer and precursor lesions in a prospective, randomized controlled study
Early-stage esophageal cancers show better treatment response but are harder to detect. Li et al. developed a deep learning pipeline to aid clinicians in identifying early-stage, high-risk esophageal lesions and tested it in a randomized clinical trial in patients undergoing endoscopy. Deep learning assistance doubled the detection of high-risk esophageal lesions compared with the unassisted control group.… Continue reading Deep learning assists detection of #esophageal #cancer and precursor lesions in a prospective, randomized controlled study
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