The majority of breast cancers are driven by oestrogen receptor-α (ERα) activation, and endocrine therapy represents the mainstay treatment for these patients1. However, resistance is common and tumours often progress after years of endocrine suppression2. Periodic fasting enhances the efficacy of standard endocrine therapy and delays acquired drug resistance, although the underlying mechanisms remain unclear3.… Continue reading #Fasting boosts #breast cancer therapy efficacy via glucocorticoid activation
Category: Oncology
#Cholangiocarcinoma 2026: status quo, unmet needs and priorities
Cholangiocarcinoma (CCA) is a cancer that originates within the bile ducts. Traditionally considered to be a rare neoplasm, increased awareness of CCA alongside advancements in diagnosis and the rising prevalence of certain risk factors have contributed to a global increase in incidence and mortality. CCAs are highly heterogeneous from the clinical, histomorphological and molecular perspectives… Continue reading #Cholangiocarcinoma 2026: status quo, unmet needs and priorities
Is there any role for #HBV pgRNA in #fibrosis and #HCC predisposition?
Aim: In this cohort, we aimed to study the evolution of pregenomic RNA (pgRNA) during treatment and compare it with other disease scores such as FIB-4 and PAGE-B.Methods: Eighty-eight HBeAg negative CHB who received long-term treatment with NAs were included. A quantitative HBV S antigen (HBsAg) assay was performed, and viral HBV DNA was quantified… Continue reading Is there any role for #HBV pgRNA in #fibrosis and #HCC predisposition?
#Statins and clinical outcomes in patients with advanced #hepatocellular carcinoma treated with #Atezolizumab plus #Bevacizumab
The impact of statins on patients receiving immune checkpoint inhibitors for advanced hepatocellular carcinoma (aHCC) remains unclear. This study aimed to evaluate whether statins influence overall survival (OS) and progression-free survival (PFS) in aHCC patients receiving Atezolizumab + Bevacizumab (A + B). ARTE is a prospectively maintained dataset of 305 aHCC patients treated with A… Continue reading #Statins and clinical outcomes in patients with advanced #hepatocellular carcinoma treated with #Atezolizumab plus #Bevacizumab
Timing and combinations of #cardiovascular diseases in survivors of childhood, adolescent, and young adulthood #cancer
Children, adolescents, and young adults with cancer (referred to as CAYAs) are at risk of long-term health complications, with cardiovascular disease (CVD) being a major concern. In addition, sociodemographic characteristics and traditional cardiovascular risk factors may also contribute to disparities in outcomes compared with those of the general population.The aim of this study was to… Continue reading Timing and combinations of #cardiovascular diseases in survivors of childhood, adolescent, and young adulthood #cancer
#Nicotinamide for #Skin #Cancer Chemoprevention
Importance Nicotinamide supplementation has been studied as a chemopreventive medication for reducing skin cancer risk, but large-scale data are limited.Objective To determine the clinical efficacy of nicotinamide supplementation for skin cancer prevention in the general population and among solid organ transplant recipients.Design, Setting, and Participants A retrospective cohort study was conducted using electronic health record… Continue reading #Nicotinamide for #Skin #Cancer Chemoprevention
Serum microRNA analysis facilitates decision-making between active surveillance and immediate surgery for low-risk #thyroid #tumors
Objective: To develop a practical and cost-effective test to distinguish patients with malignant thyroid nodules eligible for active surveillance from those requiring immediate surgery.Methods: This prospective observational study included patients with malignant thyroid nodules (3 to 15 mm) who were assigned to either an Active Surveillance Group (n = 30) or a Surgery Group (n… Continue reading Serum microRNA analysis facilitates decision-making between active surveillance and immediate surgery for low-risk #thyroid #tumors
#Cruciferous #vegetables intake and risk of #colon #cancer: a dose–response meta-analysis
Colon cancer (CC) is the third most diagnosed malignancy and second leading cause of cancer mortality globally, with ~ 1.9 million new cases and 903,859 deaths annually (Bray et al. in CA Cancer J Clin 68(6):394–424, 2018). Diet represents a key modifiable risk factor for CC pathogenesis (Herr and Buchler in Cancer Treat Rev 36:377–383, 2010). Cruciferous… Continue reading #Cruciferous #vegetables intake and risk of #colon #cancer: a dose–response meta-analysis
#Sucralose consumption ablates #cancer immunotherapy response through #microbiome disruption
Gut microbiota composition is directly associated with response to immunotherapies in cancer. How the diet impacts the gut microbiota and downstream immune responses to cancer remains unclear. Here, we show that consumption of a common non-nutritive sweetener, sucralose, modifies microbiome composition, restricts T cell metabolism and function, and limits immunotherapy response in preclinical models of… Continue reading #Sucralose consumption ablates #cancer immunotherapy response through #microbiome disruption
2 Medical News 