We examined whether wake-time movement composition was associated with weight loss maintenance among individuals who experienced clinically meaningful weight loss (> 5% of initial weight) using compositional data analysis.MethodsThis was a secondary analysis from a behavioral weight loss maintenance intervention on weight regain over 12 months following clinically meaningful 3-month weight loss. Body weight was assessed… Continue reading Association Between Wake-Time #Movement Behaviors and #Weight Loss Maintenance
Category: Neurology
Physical #activity as a modifiable risk factor in preclinical #Alzheimer’s disease
Physical inactivity is a recognized modifiable risk factor for Alzheimer’s disease (AD), yet its relationship with progression of AD pathology in humans remains unclear, limiting the effective translation into prevention trials. Using pedometer-measured step counts in cognitively unimpaired older adults, we demonstrated an association between higher physical activity and slower cognitive and functional decline in… Continue reading Physical #activity as a modifiable risk factor in preclinical #Alzheimer’s disease
High-sensitivity cardiac #troponin I and risk of #dementia: the 25-year longitudinal Whitehall II study
Background and AimsThis study hypothesizes that subclinical myocardial injury during midlife, indexed by increases in cardiac troponin I, is associated with accelerated cognitive decline, smaller structural brain volume, and higher risk of dementia.MethodsOverall, 5985 participants in the Whitehall II study, aged 45–69 who had cardiac troponin I measured by a high-sensitivity assay at baseline (1997–99),… Continue reading High-sensitivity cardiac #troponin I and risk of #dementia: the 25-year longitudinal Whitehall II study
Best Evidence Summary of Traditional Chinese Medicine Nursing Technology for Patients With Chronic #Fatigue Syndrome
The existing guidelines and expert consensus on Traditional Chinese Medicine (#TCM) nursing technology for chronic fatigue syndrome (CFS) are few and not prominent. The relevant systematic reviews and randomized controlled trials lack scientific quality evaluation resulting in a lack of systematic and standardized evidence-based evidence of TCM nursing technology in clinical practice. Therefore, this study… Continue reading Best Evidence Summary of Traditional Chinese Medicine Nursing Technology for Patients With Chronic #Fatigue Syndrome
MRI markers of #cerebrospinal fluid dynamics predict #dementia and mediate the impact of #cardiovascular risk
INTRODUCTIONImpaired cerebrospinal fluid (CSF) dynamics may contribute to dementia, but human evidence is limited. We examined associations between magnetic resonance imaging–based proxies of CSF dynamics and incident dementia, and whether CSF dysfunction mediates links between cardiovascular risk and dementia.METHODSUsing the UK Biobank, we measured CSF dynamics: perivascular space (PVS) volume, diffusion tensor image analysis along… Continue reading MRI markers of #cerebrospinal fluid dynamics predict #dementia and mediate the impact of #cardiovascular risk
#Cholesterol -lowering drug targets reduce risk of #dementia : Mendelian randomization and meta-analyses of 1 million individuals
We tested whether genetically proxied non-high-density lipoprotein cholesterol (non-HDL-C)–lowering drug targets reduce risk of all-cause dementia.METHODSWe included 1,091,775 individuals from three prospective general population cohorts with individual-level data and two consortia with summary-level data. We selected genetic variants within HMGCR, NPC1L1, PCSK9, ANGPTL4, LPL, and CETP associated with non-HDL-C. These variants were used as exposures… Continue reading #Cholesterol -lowering drug targets reduce risk of #dementia : Mendelian randomization and meta-analyses of 1 million individuals
Slow-Tempo #Music and #Delirium / #Coma -Free Days Among #Older Adults Undergoing Mechanical VentilationA Randomized Clinical Trial
Importance An estimated 70% to 80% of older adults develop delirium in the intensive care unit (ICU).Objective To determine if a slow-tempo music (60-80 beats/min) listening intervention decreases delirium duration, delirium severity, pain, or anxiety in older adults undergoing mechanical ventilation.Design, Setting, and Participants This multicenter randomized clinical trial with concealed outcomes assessments was conducted… Continue reading Slow-Tempo #Music and #Delirium / #Coma -Free Days Among #Older Adults Undergoing Mechanical VentilationA Randomized Clinical Trial
#Macroeconomic #income inequality, #brain structure and function, and #mental health
Income inequality, a structural property of societies characterized by the unequal distribution of resources, is associated with adverse mental health outcomes during adolescence, which is a sensitive period of neurodevelopment. While previous research has explored the impact of individual-level socioeconomic factors on brain structure and function, the neurobiological mechanisms linking structural inequality to mental health… Continue reading #Macroeconomic #income inequality, #brain structure and function, and #mental health
Identification of five #sleep -biopsychosocial profiles with specific neural signatures linking sleep variability with #health, cognition, and lifestyle factors
Sleep is essential for optimal functioning and health. Interconnected to multiple biological, psychological, and socio-environmental factors (i.e., biopsychosocial factors), the multidimensional nature of sleep is rarely capitalized on in research. Here, we deployed a data-driven approach to identify sleep-biopsychosocial profiles that linked self-reported sleep patterns to inter-individual variability in health, cognition, and lifestyle factors in… Continue reading Identification of five #sleep -biopsychosocial profiles with specific neural signatures linking sleep variability with #health, cognition, and lifestyle factors
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