Obstructive sleep apnea (OSA) increases risk for cognitive decline and Alzheimer’s disease (AD). While the underlying mechanisms remain unclear, hypoxemia during OSA has been implicated in cognitive impairment. OSA during rapid eye movement (REM) sleep is usually more severe than in non-rapid eye movement (NREM) sleep, but the relative effect of oxyhemoglobin desaturation during REM… Continue reading Older adults at greater risk for #Alzheimer’s disease show stronger associations between sleep #apnea severity in #REM sleep and verbal memory
Category: Neurology
The landscape of rare genetic variation associated with inflammatory #bowel disease and #Parkinson’s disease comorbidity
BackgroundInflammatory bowel disease (IBD) and Parkinson’s disease (PD) are chronic disorders that have been suggested to share common pathophysiological processes. LRRK2 has been implicated as playing a role in both diseases. Exploring the genetic basis of the IBD-PD comorbidity through studying high-impact rare genetic variants can facilitate the identification of the novel shared genetic factors underlying this… Continue reading The landscape of rare genetic variation associated with inflammatory #bowel disease and #Parkinson’s disease comorbidity
Consumption of #Olive Oil and Diet Quality and Risk of #Dementia-Related Death
Question Is the long-term consumption of olive oil associated with dementia-related death risk? Findings In a prospective cohort study of 92 383 adults observed over 28 years, the consumption of more than 7 g/d of olive oil was associated with a 28% lower risk of dementia-related death compared with never or rarely consuming olive oil, irrespective of diet… Continue reading Consumption of #Olive Oil and Diet Quality and Risk of #Dementia-Related Death
Neuronal activity in the anterior paraventricular nucleus of thalamus positively correlated with #sweetener consumption in mice
Although the brain can discriminate between various sweet substances, the underlying neural mechanisms of this complex behavior remain elusive. This study examines the role of the anterior paraventricular nucleus of the thalamus (aPVT) in governing sweet preference in mice. We fed the mice six different diets with equal sweetness for six weeks: control diet (CD),… Continue reading Neuronal activity in the anterior paraventricular nucleus of thalamus positively correlated with #sweetener consumption in mice
Navigating the #Vasculature: A Physician’s Guide to Cerebral #Angiography
n the ever-evolving landscape of medical diagnostics, cerebral angiography stands out as a powerful tool that allows physicians to delve into the intricate network of blood vessels within the brain. As physicians, our commitment to accurate diagnosis and comprehensive patient care often leads us to explore advanced imaging techniques. In this blog post, we will… Continue reading Navigating the #Vasculature: A Physician’s Guide to Cerebral #Angiography
Use of #Acid-Suppression Therapy and Odds of #Migraine and Severe Headache in the National Health and Nutrition Examination Survey
Headache is an adverse event associated with the use of proton pump inhibitors (PPIs). Recently, migraine has emerged more specifically as a potential adverse event with PPI use. The objectives of this work were to capitalize on existing data to evaluate the association between migraine and severe headache prevalence and use of acid-suppression therapy, including… Continue reading Use of #Acid-Suppression Therapy and Odds of #Migraine and Severe Headache in the National Health and Nutrition Examination Survey
Safety and efficacy of faecal #microbiota transplantation in patients with mild to moderate #Parkinson’s disease (GUT-PARFECT): a double-blind, placebo-controlled, randomised, phase 2 trial
Dysregulation of the gut microbiome has been implicated in Parkinson's disease (PD). This study aimed to evaluate the clinical effects and safety of a single faecal microbiota transplantation (FMT) in patients with early-stage PD.MethodsThe GUT-PARFECT trial, a single-centre randomised, double-blind, placebo-controlled trial was conducted at Ghent University Hospital between December 01, 2020 and December 12,… Continue reading Safety and efficacy of faecal #microbiota transplantation in patients with mild to moderate #Parkinson’s disease (GUT-PARFECT): a double-blind, placebo-controlled, randomised, phase 2 trial
Prevalence of dementia among people experiencing homelessness in Ontario, Canada: a population-based comparative analysis
Cognitive decline in people experiencing homelessness is an increasingly recognised issue. We compared the prevalence of dementia among people experiencing homelessness to housed individuals in the general population and those living in low-income neighbourhoods.MethodsWe conducted a population-based, cross-sectional, comparative analysis using linked health-care administrative data from Ontario, Canada. We included individuals aged 45 years or… Continue reading Prevalence of dementia among people experiencing homelessness in Ontario, Canada: a population-based comparative analysis
Associations of #dietary patterns with #brain health from behavioral, neuroimaging, biochemical and genetic analyses
Food preferences significantly influence dietary choices, yet understanding natural dietary patterns in populations remains limited. Here we identifiy four dietary subtypes by applying data-driven approaches to food-liking data from 181,990 UK Biobank participants: ‘starch-free or reduced-starch’ (subtype 1), ‘vegetarian’ (subtype 2), ‘high protein and low fiber’ (subtype 3) and ‘balanced’ (subtype 4). These subtypes varied… Continue reading Associations of #dietary patterns with #brain health from behavioral, neuroimaging, biochemical and genetic analyses
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