Although the brain can discriminate between various sweet substances, the underlying neural mechanisms of this complex behavior remain elusive. This study examines the role of the anterior paraventricular nucleus of the thalamus (aPVT) in governing sweet preference in mice. We fed the mice six different diets with equal sweetness for six weeks: control diet (CD),… Continue reading Neuronal activity in the anterior paraventricular nucleus of thalamus positively correlated with #sweetener consumption in mice
Category: Neurology
Navigating the #Vasculature: A Physician’s Guide to Cerebral #Angiography
n the ever-evolving landscape of medical diagnostics, cerebral angiography stands out as a powerful tool that allows physicians to delve into the intricate network of blood vessels within the brain. As physicians, our commitment to accurate diagnosis and comprehensive patient care often leads us to explore advanced imaging techniques. In this blog post, we will… Continue reading Navigating the #Vasculature: A Physician’s Guide to Cerebral #Angiography
Use of #Acid-Suppression Therapy and Odds of #Migraine and Severe Headache in the National Health and Nutrition Examination Survey
Headache is an adverse event associated with the use of proton pump inhibitors (PPIs). Recently, migraine has emerged more specifically as a potential adverse event with PPI use. The objectives of this work were to capitalize on existing data to evaluate the association between migraine and severe headache prevalence and use of acid-suppression therapy, including… Continue reading Use of #Acid-Suppression Therapy and Odds of #Migraine and Severe Headache in the National Health and Nutrition Examination Survey
Safety and efficacy of faecal #microbiota transplantation in patients with mild to moderate #Parkinson’s disease (GUT-PARFECT): a double-blind, placebo-controlled, randomised, phase 2 trial
Dysregulation of the gut microbiome has been implicated in Parkinson's disease (PD). This study aimed to evaluate the clinical effects and safety of a single faecal microbiota transplantation (FMT) in patients with early-stage PD.MethodsThe GUT-PARFECT trial, a single-centre randomised, double-blind, placebo-controlled trial was conducted at Ghent University Hospital between December 01, 2020 and December 12,… Continue reading Safety and efficacy of faecal #microbiota transplantation in patients with mild to moderate #Parkinson’s disease (GUT-PARFECT): a double-blind, placebo-controlled, randomised, phase 2 trial
Prevalence of dementia among people experiencing homelessness in Ontario, Canada: a population-based comparative analysis
Cognitive decline in people experiencing homelessness is an increasingly recognised issue. We compared the prevalence of dementia among people experiencing homelessness to housed individuals in the general population and those living in low-income neighbourhoods.MethodsWe conducted a population-based, cross-sectional, comparative analysis using linked health-care administrative data from Ontario, Canada. We included individuals aged 45 years or… Continue reading Prevalence of dementia among people experiencing homelessness in Ontario, Canada: a population-based comparative analysis
Associations of #dietary patterns with #brain health from behavioral, neuroimaging, biochemical and genetic analyses
Food preferences significantly influence dietary choices, yet understanding natural dietary patterns in populations remains limited. Here we identifiy four dietary subtypes by applying data-driven approaches to food-liking data from 181,990 UK Biobank participants: ‘starch-free or reduced-starch’ (subtype 1), ‘vegetarian’ (subtype 2), ‘high protein and low fiber’ (subtype 3) and ‘balanced’ (subtype 4). These subtypes varied… Continue reading Associations of #dietary patterns with #brain health from behavioral, neuroimaging, biochemical and genetic analyses
Morphological and genetic decoding shows heterogeneous patterns of brain aging in chronic #musculosckeletal pain
Chronic musculoskeletal pain (CMP), a prevalent and heterogeneous condition characterized by persistent pain in various body parts, is a leading cause of disability worldwide and greatly affects a patient’s brain. Apart from experiencing pain, older adults with CMP also have accelerated cognitive decline and higher dementia risk with limited understanding of biological mechanism underlying the… Continue reading Morphological and genetic decoding shows heterogeneous patterns of brain aging in chronic #musculosckeletal pain
Scanning #ultrasound-mediated memory and functional improvements do not require #amyloid-β reduction
A prevalent view in treating age-dependent disorders including Alzheimer’s disease (AD) is that the underlying amyloid plaque pathology must be targeted for cognitive improvements. In contrast, we report here that repeated scanning ultrasound (SUS) treatment at 1 MHz frequency can ameliorate memory deficits in the APP23 mouse model of AD without reducing amyloid-β (Aβ) burden. Different… Continue reading Scanning #ultrasound-mediated memory and functional improvements do not require #amyloid-β reduction
Early Use of #Erenumab vs Nonspecific Oral #Migraine PreventivesThe APPRAISE Randomized Clinical Trial
Importance Patients with migraine often cycle through multiple nonspecific preventive medications due to poor tolerability and/or inadequate efficacy leading to low adherence and increased disease burden.Objective To compare the efficacy, tolerability, patient adherence, and patient satisfaction between erenumab and nonspecific oral migraine preventive medications (OMPMs) in patients with episodic migraine (EM) who had previously failed 1 or… Continue reading Early Use of #Erenumab vs Nonspecific Oral #Migraine PreventivesThe APPRAISE Randomized Clinical Trial
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