Electroconvulsive therapy (ECT) is one of the most efficacious interventions for treatment-resistant depression. Despite its efficacy, ECT’s neural mechanism of action remains unknown. Although ECT has been associated with “slowing” in the electroencephalogram (EEG), how this change relates to clinical improvement is unresolved. Until now, increases in slow-frequency power have been assumed to indicate increases… Continue reading Clinical #EEG slowing induced by electroconvulsive therapy is better described by increased frontal aperiodic activity
Category: Neurology
The effect of #anxiety on all-cause #dementia: A longitudinal analysis from the Hunter Community Study
BackgroundAnxiety is common, however, the effect of chronicity of anxiety on dementia has not been explored. This study aims to assess the longitudinal relationship between chronic versus resolved versus new onset anxiety, and all-cause dementia risk.MethodsA total of 2132 participants with mean age 76 years from the Hunter Community Study were recruited. Anxiety was measured using… Continue reading The effect of #anxiety on all-cause #dementia: A longitudinal analysis from the Hunter Community Study
Are Blood Tests for #Alzheimer Disease Ready for Prime Time?
This is a transformative time for patients with Alzheimer disease. Alzheimer disease is increasingly viewed as a treatable condition and managed like other major chronic diseases, such as heart disease and cancer. Management of Alzheimer disease includes early diagnosis with molecular confirmation, disease-modifying treatments that are initiated early in the disease course, better risk reduction… Continue reading Are Blood Tests for #Alzheimer Disease Ready for Prime Time?
The predictive validity of a #Brain Care Score for late-life #depression and a composite outcome of #dementia, #stroke, and late-life #depression: data from the UK Biobank cohort
Introduction: The 21-point Brain Care Score (BCS) is a novel tool designed to motivate individuals and care providers to take action to reduce the risk of stroke and dementia by encouraging lifestyle changes. Given that late-life depression is increasingly recognized to share risk factors with stroke and dementia, and is an important clinical endpoint for brain… Continue reading The predictive validity of a #Brain Care Score for late-life #depression and a composite outcome of #dementia, #stroke, and late-life #depression: data from the UK Biobank cohort
#Sex and mental #health are related to subcortical #brain microstructure
SignificanceWe demonstrate the presence of large sex-related differences in the microstructure of subcortical gray matter using advanced noninvasive diffusion MRI in a large cohort of young adults. These sex differences are found in several key brain structures that are important for mental health and are consistent with experimental studies in animals showing cellular differences in… Continue reading #Sex and mental #health are related to subcortical #brain microstructure
Healthy Prenatal #Dietary Pattern and Offspring #Autism
Question What is the association between a healthy prenatal dietary pattern and offspring autism diagnosis and autism-associated traits in 2 large prospective cohort studies: the Norwegian Mother, Father, and Child Cohort (MoBa) and the Avon Study of Parents and Children (ALSPAC)?Findings In this cohort study including 84 548 mother-infant dyads in MoBa and 11 670 mother-infant dyads in ALSPAC,… Continue reading Healthy Prenatal #Dietary Pattern and Offspring #Autism
Long-Term Improvement in Hippocampal-Dependent #Learning Ability in Healthy, Aged Individuals Following High Intensity Interval #Training
AbstractPhysical exercise may reduce dementia risk in aging, but varying reports on its effectiveness make it challenging to ascribe what level of exercise will have significant longer-term effects on important functions such as hippocampal-based learning and memory. This study compared the effect of three different 6-month exercise regimens on hippocampal-dependent cognition in healthy, elderly individuals.… Continue reading Long-Term Improvement in Hippocampal-Dependent #Learning Ability in Healthy, Aged Individuals Following High Intensity Interval #Training
Efficacy of #Atogepant in Chronic #Migraine With and Without Acute Medication Overuse in the Randomized, Double-Blind, Phase 3 PROGRESS Trial
AbstractBackground and ObjectivesAtogepant is an oral, calcitonin gene-related peptide receptor antagonist approved for the preventive treatment of migraine. We evaluated the efficacy of atogepant for the preventive treatment of chronic migraine (CM) in participants with and without acute medication overuse.MethodsThis subgroup analysis of the phase 3, 12-week, randomized, double-blind, placebo-controlled PROGRESS trial evaluated adults with… Continue reading Efficacy of #Atogepant in Chronic #Migraine With and Without Acute Medication Overuse in the Randomized, Double-Blind, Phase 3 PROGRESS Trial
Nasal tau #immunotherapy clears intracellular #tau pathology and improves cognitive functions in aged tauopathy mice
Editor’s summaryTau pathology is a common denominator for neurodegenerative diseases such as Alzheimer’s disease or frontotemporal dementia, but selectively targeting toxic tau remains a challenge. Here, Gaikwad et al. developed a conformation-specific antibody for tau and demonstrated selective targeting of toxic tau aggregates in patient-derived tissue and tau oligomers in vitro. Packed into lipophile micelles, the antibody… Continue reading Nasal tau #immunotherapy clears intracellular #tau pathology and improves cognitive functions in aged tauopathy mice
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