Antivirals are infrequently prescribed in European primary care for influenza-like illness, mostly because of perceived ineffectiveness in real world primary care and because individuals who will especially benefit have not been identified in independent trials.. ..The estimated absolute mean benefit from oseltamivir was 1·02 days (95% [BCrI] 0·74–1·31) overall, and in the prespecified subgroups, ranged… Continue reading Oseltamivir plus usual care versus usual care for #influenza-like illness in primary care: an open-label, pragmatic, randomised controlled trial
Category: Infectivology
Antibiotic prescribing without documented indication in ambulatory care clinics: national cross sectional study
... According to the criteria, 57% (52% to 62%) of the 130.5 million prescriptions were for appropriate indications, 25% (21% to 29%) were inappropriate, and 18% (15% to 22%) had no documented indication. This corresponds to an estimated 24 million prescriptions without a documented indication. Being an adult male, spending more time with the provider,… Continue reading Antibiotic prescribing without documented indication in ambulatory care clinics: national cross sectional study
Prediction model for #pneumonia in primary care patients with an acute respiratory tract infection: role of symptoms, signs, and biomarkers
Diagnosing pneumonia can be challenging in general practice but is essential to distinguish from other respiratory tract infections because of treatment choice and outcome prediction.. ..Two hundred forty-nine patients were included of whom 30 (12%) displayed a consolidation on chest X ray. Absence of runny nose and whether or not a patient felt ill were… Continue reading Prediction model for #pneumonia in primary care patients with an acute respiratory tract infection: role of symptoms, signs, and biomarkers
Association Between Acute #Gastroenteritis and Continuous Use of Proton Pump Inhibitors During Winter Periods of Highest Circulation of Enteric Viruses
An increased risk of acute bacterial enteric infections has been reported among patients receiving proton pump inhibitor (#PPI) therapy. The risk of acute gastroenteritis (AGE) of viral origin associated with continuous PPI exposure has been less studied ..At least 1 AGE epidemic episode was identified in 3131 patients (1.3%) receiving PPI therapy and in 4327… Continue reading Association Between Acute #Gastroenteritis and Continuous Use of Proton Pump Inhibitors During Winter Periods of Highest Circulation of Enteric Viruses
Adjunctive #Rifampin Therapy For Diabetic Foot #Osteomyelitis in the Veterans Health Administration
Among patients diagnosed with diabetes, the lifetime incidence of foot ulcers is 15%. Infection is a common complication of foot ulcers, and 20% to 60% of infections result in diabetic foot osteomyelitis (DFO). ..Patients initiating rifampin therapy within 6 weeks of the DFO diagnosis and receiving the drug for at least 14 days within 90… Continue reading Adjunctive #Rifampin Therapy For Diabetic Foot #Osteomyelitis in the Veterans Health Administration
#Nanoparticle-induced #neutrophil apoptosis increases survival in #sepsis and alleviates neurological damage in #stroke
Human neutrophils are the most abundant circulating leukocytes and contribute to acute and chronic inflammatory disorders. Neutrophil apoptosis is programed cell death to maintain immune homeostasis, but inflammatory responses to infections or tissue injury disrupt neutrophil death program, leading to many diseases. Precise control of neutrophil apoptosis may resolve inflammation to return immune homeostasis. Here,… Continue reading #Nanoparticle-induced #neutrophil apoptosis increases survival in #sepsis and alleviates neurological damage in #stroke
Activity of Hospital #Disinfectants against Vegetative Cells and Spores of #Clostridioides difficile Embedded in Biofilms
Clostridioides difficile spores can survive in the environment either in mono- or mixed-species biofilms. However, no previous studies have investigated chemical disinfection of C. difficile spores embedded in biofilms.. C. difficile vegetative cells and spores were recovered from biofilms regardless the type of biofilm growth or biofilm growth time. No disinfectant was able to completely… Continue reading Activity of Hospital #Disinfectants against Vegetative Cells and Spores of #Clostridioides difficile Embedded in Biofilms
Evidence-based clinical practice guideline on #antibiotic use for the urgent management of pulpal- and periapical-related #dental pain and intraoral swelling
..systematic review and formulated clinical recommendations for the urgent management of symptomatic irreversible pulpitis with or without symptomatic apical #periodontitis, pulp necrosis and symptomatic apical periodontitis, or pulp necrosis and localized acute apical abscess using antibiotics, either alone or as adjuncts to definitive, conservative dental treatment (DCDT) in immunocompetent adults. The panel formulated 5 clinical… Continue reading Evidence-based clinical practice guideline on #antibiotic use for the urgent management of pulpal- and periapical-related #dental pain and intraoral swelling
Drug-Resistant E. #coli Bacteremia Transmitted by Fecal Microbiota Transplant
Fecal microbiota transplantation (#FMT) is an emerging therapy for recurrent or refractory Clostridioides difficile infection and is being actively investigated for other conditions. We describe two patients in whom extended-spectrum beta-lactamase (ESBL)–producing Escherichia coli bacteremia occurred after they had undergone FMT in two independent clinical trials; both cases were linked to the same stool donor… Continue reading Drug-Resistant E. #coli Bacteremia Transmitted by Fecal Microbiota Transplant
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