Low serum albumin levels resulting from inflammation-induced capillary leakage or disease-related anorexia during acute illness are associated with poor outcomes. We investigated the relationship of nutritional status and inflammation with low serum albumin levels and 30-day mortality in a large cohort.. Among the 2465 patients, 1019 (41%) had low serum albumin levels (<34 g/L), 619… Continue reading Relationship of #Nutritional Status, #Inflammation, and Serum #Albumin Levels During Acute Illness: A Prospective Study
Category: Infectivology
Homologous recombination within the spike glycoprotein of the newly identified #coronavirus may boost cross‐species transmission from snake to human
The current outbreak of viral pneumonia in the city of Wuhan, China, was caused by a novel coronavirus designated 2019‐nCoV by the World Health Organization, as determined by sequencing the viral RNA genome. Many patients were potentially exposed to wildlife animals at the Huanan seafood wholesale market, where poultry, snake, bats, and other farm animals… Continue reading Homologous recombination within the spike glycoprotein of the newly identified #coronavirus may boost cross‐species transmission from snake to human
Prevention of #tuberculosis in macaques after intravenous BCG immunization
Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide. The only available vaccine, BCG (Bacillus Calmette–Guérin), is given intradermally and has variable efficacy against pulmonary tuberculosis, the major cause of mortality and disease transmission. Here we show that intravenous administration of BCG profoundly alters the protective outcome of Mtb challenge in non-human… Continue reading Prevention of #tuberculosis in macaques after intravenous BCG immunization
Adrenergic Signaling in #Muscularis Macrophages Limits Infection-Induced Neuronal Loss
..Enteric-associated neurons (EANs) are closely associated with immune cells and continuously monitor and modulate homeostatic intestinal functions, including motility and nutrient sensing. Bidirectional interactions between neuronal and immune cells are altered during disease processes such as neurodegeneration or #irritable bowel syndrome. We investigated the effects of infection-induced inflammation on intrinsic EANs (iEANs) and the role… Continue reading Adrenergic Signaling in #Muscularis Macrophages Limits Infection-Induced Neuronal Loss
T cell receptor cross-reactivity between gliadin and #bacterial peptides in #celiac disease
The human leukocyte antigen (HLA) locus is strongly associated with T cell-mediated autoimmune disorders. HLA-DQ2.5-mediated celiac disease (CeD) is triggered by the ingestion of gluten, although the relative roles of genetic and environmental risk factors in CeD is unclear. Here we identify microbially derived mimics of gliadin epitopes and a parental bacterial protein that is… Continue reading T cell receptor cross-reactivity between gliadin and #bacterial peptides in #celiac disease
Predictors of #mortality of #influenza virus infections in a Swiss Hospital during four influenza seasons: Role of quick sequential organ failure assessment
..Thirty-day mortality was 6.0% (25 patients). Multivariate analysis revealed that infection due to A virus (P 0.035; OR 7.1; 95% CI 1.1–43.8), malnutrition (P < 0.001; OR 25.0; 95% CI 4.5–138.8), hospital-acquired infection (P 0.003; OR 12.2; 95% CI 2.3–65.1), respiratory insufficiency (PaO2/FiO2 < 300) (P < 0.001; OR 125.8; 95% CI 9.6–1648.7) and pulmonary… Continue reading Predictors of #mortality of #influenza virus infections in a Swiss Hospital during four influenza seasons: Role of quick sequential organ failure assessment
Prevalence of Human #Papillomavirus Infection by Number of Vaccine Doses Among US Women
..Compared with unvaccinated women (prevalence of 12.5% [95% CI, 9.7%-15.3%]), infection with HPV type 6, 11, 16, or 18 was significantly less prevalent among women who received 1 dose (2.4% [95% CI, 0%-4.9%]), 2 doses (5.1% [95% CI, 0.8%-9.5%]), or 3 doses (3.1% [95% CI, 0.9%-5.3%]) of HPV vaccine (Table 1). There was no significant… Continue reading Prevalence of Human #Papillomavirus Infection by Number of Vaccine Doses Among US Women
Oseltamivir plus usual care versus usual care for #influenza-like illness in primary care: an open-label, pragmatic, randomised controlled trial
Antivirals are infrequently prescribed in European primary care for influenza-like illness, mostly because of perceived ineffectiveness in real world primary care and because individuals who will especially benefit have not been identified in independent trials.. ..The estimated absolute mean benefit from oseltamivir was 1·02 days (95% [BCrI] 0·74–1·31) overall, and in the prespecified subgroups, ranged… Continue reading Oseltamivir plus usual care versus usual care for #influenza-like illness in primary care: an open-label, pragmatic, randomised controlled trial
Antibiotic prescribing without documented indication in ambulatory care clinics: national cross sectional study
... According to the criteria, 57% (52% to 62%) of the 130.5 million prescriptions were for appropriate indications, 25% (21% to 29%) were inappropriate, and 18% (15% to 22%) had no documented indication. This corresponds to an estimated 24 million prescriptions without a documented indication. Being an adult male, spending more time with the provider,… Continue reading Antibiotic prescribing without documented indication in ambulatory care clinics: national cross sectional study
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