Objective To prospectively assess the effect of endometriosis and uterine fibroids on the long term risk of premature mortality (younger than 70 years).Design Prospective cohort studySetting The Nurses’ Health Study II, United States (1989-2019).Participants 110 091 women aged 25-42 years in 1989 without a history of hysterectomy before endometriosis or fibroids diagnosis, cardiovascular diseases, or cancer.Main… Continue reading #Endometriosis and uterine #fibroids and risk of premature mortality: prospective cohort study
Category: Gynaecology
High #sperm deoxyribonucleic acid fragmentation index is associated with an increased risk of #preeclampsia following assisted reproduction treatment
ObjectiveTo study the association between sperm deoxyribonucleic acid fragmentation index (DFI) and the odds of preeclampsia and other adverse perinatal outcomes after in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) treatment. DesignA prospective cohort study including infertile couples undergoing conventional IVF or ICSI treatment and their children. Data regarding preeclampsia and perinatal outcomes were… Continue reading High #sperm deoxyribonucleic acid fragmentation index is associated with an increased risk of #preeclampsia following assisted reproduction treatment
Identification of distinct #stool metabolites in women with #endometriosis for non-invasive diagnosis and potential for microbiota-based therapies
Context and significanceClinical management of endometriosis, a gynecological disease that is a leading cause of infertility in women, remains a challenge with no known cure. Scientists from Baylor College of Medicine combined the gut metabolomic and microbiota signatures in the stool samples from women with endometriosis to identify a gut-bacteria-derived therapeutic intervention candidate, 4-hydroxyindole. They… Continue reading Identification of distinct #stool metabolites in women with #endometriosis for non-invasive diagnosis and potential for microbiota-based therapies
Premenopausal bilateral #oophorectomy and #brain white matter brain integrity in later-life
INTRODUCTIONPremenopausal bilateral oophorectomy (PBO) is associated with later-life cognition, but the underlying brain changes remain unclear. We assessed the impact of PBO and PBO age on white matter integrity.METHODSFemale participants with regional diffusion tensor imaging (DTI) metrics of fractional anisotropy (FA) and mean diffusivity (MD) were included (22 with PBO < 40 years; 43 with PBO 40-45… Continue reading Premenopausal bilateral #oophorectomy and #brain white matter brain integrity in later-life
#Artemisinins ameliorate #polycystic ovarian syndrome by mediating LONP1-CYP11A1 interaction
Editor’s summaryPolycystic ovary syndrome is a common endocrine condition in women of reproductive age. Its manifestations include androgen excess and other hormonal changes, menstrual cycle alterations, infertility, and metabolic abnormalities. Artemisinins are plant-derived compounds that are best known for their antimalarial properties but have also been shown to have some beneficial metabolic effects. Liu et al.… Continue reading #Artemisinins ameliorate #polycystic ovarian syndrome by mediating LONP1-CYP11A1 interaction
#Mortality Risk Among Women With #Premenstrual Disorders in Sweden
Key PointsQuestion Do women with premenstrual disorders (PMDs) have higher risks of all-cause and cause-specific mortality compared with women without PMDs?Findings This nationwide matched cohort study of 406 488 women in Sweden during a mean (SD) follow-up of 6.2 (4.6) years (range, 1-18 years) revealed that overall, women with diagnosed PMDs did not have an increased risk of… Continue reading #Mortality Risk Among Women With #Premenstrual Disorders in Sweden
30 – Early-Life #Tobacco Exposure, Genetic Risk, and Incident Type 2 #Diabetes
Tobacco exposure in adulthood is a well-established risk factor for type 2 diabetes (T2D), but how early-life tobacco exposure implicates in the development of T2D as well as whether this association varies by different genetic predisposition to T2D are unclear. Addressing these gaps may provide novel insights into early interventions of T2D.Hypothesis We hypothesized that tobacco… Continue reading 30 – Early-Life #Tobacco Exposure, Genetic Risk, and Incident Type 2 #Diabetes
PRAC recommends new measures to avoid #topiramate exposure in #pregnancy
Further restrictions on use; pregnancy prevention programme to be put in placeEMA’s safety committee (PRAC) recommends new measures to avoid exposure of children to topiramate-containing medicines in the womb, because the medicine may increase the risk of neurodevelopmental problems after exposure during pregnancy. Topiramate is already known to cause serious birth defects when used during… Continue reading PRAC recommends new measures to avoid #topiramate exposure in #pregnancy
Population-based cohort study of oral contraceptive use and risk of depression
Research on the effect of oral contraceptive (OC) use on the risk of depression shows inconsistent findings, especially in adult OC users. One possible reason for this inconsistency is the omission of women who discontinue OCs due to adverse mood effects, leading to healthy user bias. To address this issue, we aim to estimate the… Continue reading Population-based cohort study of oral contraceptive use and risk of depression
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